STN1 and TRIML2

Data Source:
BioGRID (two hybrid)

		STN1	TRIML2
Description		STN1 subunit of CST complex	tripartite motif family like 2
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Fibrillar Center Nucleus Nucleoplasm Intracellular Membrane-bounded Organelle Intermediate Filament Cytoskeleton CST Complex	Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Single-stranded DNA Binding Protein Binding Telomeric DNA Binding Single-stranded Telomeric DNA Binding	Protein Binding Protein Kinase Binding Identical Protein Binding Protein Homodimerization Activity Ubiquitin Protein Ligase Activity
	Biological Process	Telomere Maintenance Telomere Maintenance Via Telomere Lengthening Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of DNA Replication	Protein Polyubiquitination Regulation Of Gene Expression Positive Regulation Of Autophagy Protein Ubiquitination Response To Retinoic Acid Regulation Of Protein Localization Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Regulation Of Viral Entry Into Host Cell Positive Regulation Of NF-kappaB Transcription Factor Activity
Pathways		Polymerase switching on the C-strand of the telomere Telomere C-strand synthesis initiation
Drugs
Diseases
GWAS		Chronic obstructive pulmonary disease ( 30804561) Leukocyte telomere length ( 32109421) Uterine fibroids ( 31488892 30194396) White matter integrity (mean diffusivity) ( 32358547)	Polycystic ovary syndrome ( 25574032)
Interacting Genes		19 interacting genes: APP C14orf119 C1orf109 CDK3 GOLGA2 LDLRAP1 LRRK2 MFHAS1 MKRN3 MVP NTAQ1 RCOR3 TEN1 TOLLIP TPP1 TRIML2 TUBGCP4 TXN2 ZDHHC17	48 interacting genes: ABI2 BLOC1S2 CBY2 CCDC146 CCDC92 CCHCR1 CCNH CDR2 CTBP2 EIF2B1 EIF3M FAM90A1 FAM9C HGS ING5 ITGB3BP KRT15 KRT24 KRT27 KRT31 KRT34 KRT38 KRT75 MBD3L2 MBD3L3 MEOX1 MEOX2 NECAB2 NFKBID NUP62 PICK1 POLR1H POU6F2 SH2D4A STN1 SUMO2 SYCE2 TBC1D25 TCF4 TFIP11 TRIM54 TSEN54 TSG101 USHBP1 XAF1 ZBED1 ZBTB33 ZFHX3
Entrez ID		79991	205860
HPRD ID		14872	08696
Ensembl ID		ENSG00000107960	ENSG00000179046
Uniprot IDs		Q9H668	B7ZLC3 Q8N7C3
PDB IDs		4JOI 4JQF 6W6W
Enriched GO Terms of Interacting Partners?
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