TRMT2B and ERCC1

Data Source:
BioGRID (two hybrid)

		TRMT2B	ERCC1
Description		tRNA methyltransferase 2 homolog B	ERCC excision repair 1, endonuclease non-catalytic subunit
Image		No pdb structure
GO Annotations	Cellular Component		Nucleotide-excision Repair Complex Nucleotide-excision Repair Factor 1 Complex Chromosome, Telomeric Region Nucleoplasm Cytoplasm ERCC4-ERCC1 Complex
	Molecular Function	Protein Binding S-adenosylmethionine-dependent TRNA (m5U54) Methyltransferase Activity	Single-stranded DNA Endodeoxyribonuclease Activity TFIID-class Transcription Factor Complex Binding DNA Binding Damaged DNA Binding Single-stranded DNA Binding Protein Binding Protein C-terminus Binding Protein Domain Specific Binding 3' Overhang Single-stranded DNA Endodeoxyribonuclease Activity Promoter-specific Chromatin Binding
	Biological Process	TRNA Methylation	Meiotic Mismatch Repair Pyrimidine Dimer Repair By Nucleotide-excision Repair DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair Nucleotide-excision Repair, Preincision Complex Stabilization Nucleotide-excision Repair, DNA Incision, 3'-to Lesion Nucleotide-excision Repair, DNA Incision, 5'-to Lesion Double-strand Break Repair Via Nonhomologous End Joining DNA Recombination Mitotic Recombination Syncytium Formation Response To Oxidative Stress Spermatogenesis Response To Nutrient Cell Population Proliferation Male Gonad Development UV Protection Response To Sucrose Response To X-ray Multicellular Organism Aging Negative Regulation Of Telomere Maintenance Nucleotide-excision Repair, DNA Incision Post-embryonic Hemopoiesis Multicellular Organism Growth Response To Immobilization Stress Interstrand Cross-link Repair Isotype Switching Response To Cadmium Ion Oogenesis Embryonic Organ Development Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter Telomeric DNA-containing Double Minutes Formation Global Genome Nucleotide-excision Repair UV-damage Excision Repair Replicative Senescence T-circle Formation Positive Regulation Of T-circle Formation Negative Regulation Of Protection From Non-homologous End Joining At Telomere
Pathways			HDR through Single Strand Annealing (SSA) Formation of Incision Complex in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Fanconi Anemia Pathway
Drugs
Diseases			Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome
GWAS			Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x age interaction ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Simvastatin-induced myopathy ( 31220337)
Interacting Genes		3 interacting genes: AKT1 ERCC1 PTPN11	18 interacting genes: APP CHRM5 ERCC4 GAS8 KIF11 MKRN3 RAD52 RPA1 RPA2 RPA3 SLX1A TRMT2B UBL7 UHRF1 USHBP1 USP45 VPS37B XPA
Entrez ID		79979	2067
HPRD ID		06520	00533
Ensembl ID		ENSG00000188917	ENSG00000012061
Uniprot IDs		A0A024RCF5 Q96GJ1	A0A024R0Q6 P07992
PDB IDs			1Z00 2A1I 2A1J 2JNW 2JPD 2MUT 6SXA 6SXB
Enriched GO Terms of Interacting Partners?
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