RPP21 and RPP40

Data Source:
HPRD (in vitro)

		RPP21	RPP40
Description		ribonuclease P/MRP subunit p21	ribonuclease P/MRP subunit p40
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GO Annotations	Cellular Component	Nucleoplasm Nucleolar Ribonuclease P Complex Multimeric Ribonuclease P Complex	Ribonuclease MRP Complex Nucleus Nucleoplasm Nucleolar Ribonuclease P Complex Multimeric Ribonuclease P Complex
	Molecular Function	Ribonuclease P Activity Ribonuclease P RNA Binding Metal Ion Binding	Ribonuclease MRP Activity Ribonuclease P Activity Ribonuclease P RNA Binding
	Biological Process	TRNA 5'-leader Removal TRNA Processing Response To Drug RNA Phosphodiester Bond Hydrolysis, Endonucleolytic	Endonucleolytic Cleavage In ITS1 To Separate SSU-rRNA From 5.8S RRNA And LSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRNA 5'-leader Removal Endonucleolytic Cleavage Involved In TRNA Processing
Pathways		tRNA processing in the nucleus Major pathway of rRNA processing in the nucleolus and cytosol	tRNA processing in the nucleus Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Cutaneous lupus erythematosus ( 25827949) Moderate to vigorous physical activity levels ( 29899525) Neurociticism ( 29500382) Neuroticism ( 29255261) Sarcoidosis (Lofgren's syndrome vs non-Lofgren's syndrome) ( 26651848)
Interacting Genes		3 interacting genes: RPP30 RPP38 RPP40	8 interacting genes: MEOX2 POP1 POP7 PTEN RPP14 RPP21 RPP30 RPP38
Entrez ID		79897	10799
HPRD ID		15275	09361
Ensembl ID		ENSG00000241370	ENSG00000124787
Uniprot IDs		A0A1U9X8H3 Q9H633	A0A087X1N3 O75818
PDB IDs		6AHR 6AHU	6AHR 6AHU 6AHV
Enriched GO Terms of Interacting Partners?
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