RPP40 and RPP21

Data Source:
HPRD (in vitro)

		RPP40	RPP21
Description		ribonuclease P/MRP subunit p40	ribonuclease P/MRP subunit p21
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GO Annotations	Cellular Component	Ribonuclease MRP Complex Nucleus Nucleoplasm Nucleolar Ribonuclease P Complex Multimeric Ribonuclease P Complex	Nucleoplasm Nucleolar Ribonuclease P Complex Multimeric Ribonuclease P Complex
	Molecular Function	Ribonuclease MRP Activity Ribonuclease P Activity Ribonuclease P RNA Binding	Ribonuclease P Activity Ribonuclease P RNA Binding Metal Ion Binding
	Biological Process	Endonucleolytic Cleavage In ITS1 To Separate SSU-rRNA From 5.8S RRNA And LSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRNA 5'-leader Removal Endonucleolytic Cleavage Involved In TRNA Processing	TRNA 5'-leader Removal TRNA Processing Response To Drug RNA Phosphodiester Bond Hydrolysis, Endonucleolytic
Pathways		tRNA processing in the nucleus Major pathway of rRNA processing in the nucleolus and cytosol	tRNA processing in the nucleus Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS			Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Cutaneous lupus erythematosus ( 25827949) Moderate to vigorous physical activity levels ( 29899525) Neurociticism ( 29500382) Neuroticism ( 29255261) Sarcoidosis (Lofgren's syndrome vs non-Lofgren's syndrome) ( 26651848)
Interacting Genes		8 interacting genes: MEOX2 POP1 POP7 PTEN RPP14 RPP21 RPP30 RPP38	3 interacting genes: RPP30 RPP38 RPP40
Entrez ID		10799	79897
HPRD ID		09361	15275
Ensembl ID		ENSG00000124787	ENSG00000241370
Uniprot IDs		A0A087X1N3 O75818	A0A1U9X8H3 Q9H633
PDB IDs		6AHR 6AHU 6AHV	6AHR 6AHU
Enriched GO Terms of Interacting Partners?
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