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GALNT12 and FBXW7
Data Source:
BioGRID
(two hybrid)
GALNT12
FBXW7
Description
polypeptide N-acetylgalactosaminyltransferase 12
F-box and WD repeat domain containing 7
Image
GO Annotations
Cellular Component
Golgi Membrane
Golgi Apparatus
Integral Component Of Membrane
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Mitochondrion
Endoplasmic Reticulum
Golgi Apparatus
Cytosol
SCF Ubiquitin Ligase Complex
Perinuclear Region Of Cytoplasm
Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex
Molecular Function
Polypeptide N-acetylgalactosaminyltransferase Activity
Carbohydrate Binding
Metal Ion Binding
Protein Binding
Cyclin Binding
Protein-macromolecule Adaptor Activity
Ubiquitin Protein Ligase Binding
Identical Protein Binding
Ubiquitin Binding
Phosphothreonine Residue Binding
Ubiquitin-protein Transferase Activator Activity
Biological Process
O-glycan Processing
Protein Phosphopantetheinylation
Protein Polyubiquitination
Vasculogenesis
Vasculature Development
Sister Chromatid Cohesion
Notch Signaling Pathway
Negative Regulation Of Gene Expression
Negative Regulation Of Triglyceride Biosynthetic Process
Regulation Of Lipid Storage
Ubiquitin Recycling
Viral Process
Protein Ubiquitination
Lung Development
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Protein Ubiquitination
Protein Destabilization
Regulation Of Protein Localization
Regulation Of Circadian Rhythm
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Post-translational Protein Modification
Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity
Negative Regulation Of Notch Signaling Pathway
Rhythmic Process
Protein Stabilization
Positive Regulation Of Ubiquitin-protein Transferase Activity
Lipid Homeostasis
Positive Regulation Of ERK1 And ERK2 Cascade
Regulation Of Cell Migration Involved In Sprouting Angiogenesis
Positive Regulation Of Proteasomal Protein Catabolic Process
Regulation Of Cell Cycle G1/S Phase Transition
Negative Regulation Of RNA Polymerase II Regulatory Region Sequence-specific DNA Binding
Regulation Of Autophagy Of Mitochondrion
Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Protein Targeting To Mitochondrion
Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Hepatocyte Proliferation
Negative Regulation Of SREBP Signaling Pathway
Negative Regulation Of Osteoclast Development
Pathways
Defective GALNT12 causes colorectal cancer 1 (CRCS1)
O-linked glycosylation of mucins
Association of TriC/CCT with target proteins during biosynthesis
Neddylation
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
Asthma (
31959851
)
Brain morphology (MOSTest) (
32665545
)
FEV1 (
30804560
)
Gut microbiota (bacterial taxa, hurdle binary method) (
32572223
)
Lung function (FEV1/FVC) (
30804560
)
Peak expiratory flow (
30804560
)
Eosinophil counts (
32888494
)
Eosinophil percentage of white cells (
32888494
)
Interacting Genes
16 interacting genes:
APP
BMPR1A
BUB1
CDH1
CDKN2A
FBXW7
MLH3
MSH2
MUC1
MUC2
MUC5AC
MUC7
PIK3CA
PMS2
RB1
SRC
77 interacting genes:
AHSG
AKT1
ANGPTL4
ANP32B
ARL6IP1
BCAS3
BEX1
BLM
CCDC6
CCNE1
CCNE2
CDC34
CEBPD
CUL1
DISC1
DVL1
EBNA1BP2
EXT1
EZH2
FANCC
FBP1
FBP2
GALNT12
GATA2
GATA3
GFI1
GLMN
HEMGN
HEY1
HIPK2
HNRNPK
HRAS
IGFBP3
IL24
JUN
KLF10
KLF5
LINGO1
MAP2K1
MAPK3
MMS22L
MYB
MYC
MYCN
NANS
NOTCH1
NOTCH4
NPM1
PLK1
PPARGC1A
PPP3R2
PRKN
PSEN1
PTPN11
RACK1
RFLNA
SCGB3A1
SEC61B
SHC1
SHPRH
SKP1
SMAD1
SOX9
SREBF1
STAT3
STAT5A
STOML1
STYX
SUMF2
TGFB1
TMOD1
TP53
TSC22D4
USP9X
WDR97
XPA
ZNF510
Entrez ID
79695
55294
HPRD ID
13561
05888
Ensembl ID
ENSG00000119514
ENSG00000109670
Uniprot IDs
Q8IXK2
G0Z2K0
Q969H0
S4R3U4
PDB IDs
6PXU
2OVP
2OVQ
2OVR
5IBK
5V4B
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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