NDUFS2 and CENPU

Data Source:
BioGRID (two hybrid)

		NDUFS2	CENPU
Description		NADH:ubiquinone oxidoreductase core subunit S2	centromere protein U
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Respiratory Chain Complex I Mitochondrial Matrix	Condensed Chromosome Kinetochore Nucleus Nucleoplasm Cytosol Centriolar Satellite
	Molecular Function	NADH Dehydrogenase Activity Protein Binding NADH Dehydrogenase (ubiquinone) Activity Electron Transfer Activity Ubiquitin Protein Ligase Binding Metal Ion Binding Quinone Binding NAD Binding 4 Iron, 4 Sulfur Cluster Binding	Protein Binding
	Biological Process	Mitochondrial Electron Transport, NADH To Ubiquinone Response To Oxidative Stress Mitochondrial Respiratory Chain Complex I Assembly Mitochondrial ATP Synthesis Coupled Electron Transport	Viral Process CENP-A Containing Nucleosome Assembly Chordate Embryonic Development
Pathways		Respiratory electron transport Complex I biogenesis	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs		NADH
Diseases		Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 31361310) Asthma ( 31361310 30929738 31619474) Asthma (childhood onset) ( 30929738) Asthma onset (childhood vs adult) ( 30929738) Granulocyte percentage of myeloid white cells ( 27863252)
Interacting Genes		5 interacting genes: APP CENPU EGR2 HMOX2 TNFRSF14	17 interacting genes: E2F6 EIF4G1 GIT1 LAMC1 MLF1 NDUFS2 NUP62 PGRMC1 PLK2 PLK3 PLXNB2 ROBO2 SPTBN4 TFIP11 TUBB2B UPF2 XRCC6
Entrez ID		4720	79682
HPRD ID		04285	14722
Ensembl ID		ENSG00000158864	ENSG00000151725
Uniprot IDs		B7Z792 O75306	Q71F23
PDB IDs		5XTB 5XTC 5XTD 5XTH 5XTI
Enriched GO Terms of Interacting Partners?
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