TUBB2B and CENPU

Data Source:
BioGRID (two hybrid)

		TUBB2B	CENPU
Description		tubulin beta 2B class IIb	centromere protein U
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Microtubule Microtubule Cytoskeleton Schaffer Collateral - CA1 Synapse	Condensed Chromosome Kinetochore Nucleus Nucleoplasm Cytosol Centriolar Satellite
	Molecular Function	GTPase Activity Structural Constituent Of Cytoskeleton Protein Binding GTP Binding Protein Heterodimerization Activity	Protein Binding
	Biological Process	Microtubule Cytoskeleton Organization Mitotic Cell Cycle Neuron Migration Microtubule-based Process Modulation Of Chemical Synaptic Transmission Positive Regulation Of Axon Guidance Embryonic Brain Development	Viral Process CENP-A Containing Nucleosome Assembly Chordate Embryonic Development
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Gap junction assembly MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion HSP90 chaperone cycle for steroid hormone receptors (SHR) Recruitment of NuMA to mitotic centrosomes Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Post-chaperonin tubulin folding pathway Recycling pathway of L1 Recycling pathway of L1 Hedgehog 'off' state Cilium Assembly Intraflagellar transport RHO GTPases activate IQGAPs RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase The role of GTSE1 in G2/M progression after G2 checkpoint Carboxyterminal post-translational modifications of tubulin Carboxyterminal post-translational modifications of tubulin HCMV Early Events Assembly and cell surface presentation of NMDA receptors Activation of AMPK downstream of NMDARs Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation Sealing of the nuclear envelope (NE) by ESCRT-III Kinesins	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs		CYT997 2-MERCAPTO-N-[1,2,3,10-TETRAMETHOXY-9-OXO-5,6,7,9-TETRAHYDRO-BENZO[A]HEPTALEN-7-YL]ACETAMIDE
Diseases
GWAS
Interacting Genes		10 interacting genes: ANXA7 BID C8orf33 CACNA1A CDKN1A CENPU CSNK2B HDAC6 RGS2 RPL35	17 interacting genes: E2F6 EIF4G1 GIT1 LAMC1 MLF1 NDUFS2 NUP62 PGRMC1 PLK2 PLK3 PLXNB2 ROBO2 SPTBN4 TFIP11 TUBB2B UPF2 XRCC6
Entrez ID		347733	79682
HPRD ID		14707	14722
Ensembl ID		ENSG00000137285	ENSG00000151725
Uniprot IDs		A0A384MEE3 Q9BVA1	Q71F23
PDB IDs		6E7C
Enriched GO Terms of Interacting Partners?
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