CALCA and RAMP2

Data Source:
HPRD (in vitro)

		CALCA	RAMP2
Description		calcitonin related polypeptide alpha	receptor activity modifying protein 2
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Neuronal Cell Body Terminal Bouton	Cytoplasm Lysosome Plasma Membrane Integral Component Of Plasma Membrane Clathrin-coated Pit Cell Surface Receptor Complex Amylin Receptor Complex 2 Adrenomedullin Receptor Complex
	Molecular Function	Hormone Activity Protein Binding Calcitonin Receptor Binding Identical Protein Binding	Adrenomedullin Receptor Activity Protein Binding Coreceptor Activity Amylin Receptor Activity Adrenomedullin Binding
	Biological Process	Artery Vasodilation Involved In Baroreceptor Response To Increased Systemic Arterial Blood Pressure Monocyte Chemotaxis Inflammatory Response G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Neuropeptide Signaling Pathway Embryo Implantation Aging Feeding Behavior Regulation Of Heart Contraction Response To Heat Negative Regulation Of Ossification Activation Of Protein Kinase Activity Cellular Protein Metabolic Process Negative Regulation Of Bone Resorption Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Smooth Muscle Contraction Response To Pain Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway Cellular Response To Tumor Necrosis Factor Cellular Response To Nerve Growth Factor Stimulus	Angiogenesis Vasculogenesis Response To Hypoxia Sprouting Angiogenesis Calcium Ion Transport Intracellular Protein Transport G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Heart Development Female Pregnancy Regulation Of Blood Pressure Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Gene Expression Protein Transport Receptor Internalization Positive Regulation Of Protein Binding Response To Estradiol Response To Progesterone Cellular Response To Hormone Stimulus Adherens Junction Assembly Cellular Response To Vascular Endothelial Growth Factor Stimulus Negative Regulation Of Vascular Permeability Positive Regulation Of Angiogenesis Bicellular Tight Junction Assembly Basement Membrane Assembly Protein Localization To Plasma Membrane Vascular Associated Smooth Muscle Cell Development Amylin Receptor Signaling Pathway Adrenomedullin Receptor Signaling Pathway Negative Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Vasculogenesis
Pathways		G alpha (s) signalling events Calcitonin-like ligand receptors ADORA2B mediated anti-inflammatory cytokines production Amyloid fiber formation G alpha (s) signalling events Calcitonin-like ligand receptors ADORA2B mediated anti-inflammatory cytokines production	G alpha (s) signalling events Calcitonin-like ligand receptors ADORA2B mediated anti-inflammatory cytokines production
Drugs		Olcegepant Telcagepant Eptinezumab Fremanezumab Galcanezumab	Pramlintide
Diseases
GWAS		Diverticular disease ( 30177863) Vitamin D levels ( 25208829)	Pulse pressure ( 30224653)
Interacting Genes		8 interacting genes: ANKRD11 BBS1 BBS4 CALCRL ECE1 NRDC RAMP1 RAMP2	7 interacting genes: CALCA CALCRL CIDEB IAPP LCN2 SLC31A2 VIPR1
Entrez ID		796	10266
HPRD ID		00238	05516
Ensembl ID		ENSG00000110680	ENSG00000131477
Uniprot IDs		P01258 P06881	A0A024R1Z2 O60895
PDB IDs		1LS7 2JXZ 6E3Y	2XVT 3AQE 3AQF 4RWF 6UUN 6V2E
Enriched GO Terms of Interacting Partners?
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