CALCA and ECE1

Data Source:
BioGRID (enzymatic study)

		CALCA	ECE1
Description		calcitonin related polypeptide alpha	endothelin converting enzyme 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Neuronal Cell Body Terminal Bouton	Lysosomal Membrane Endosome Plasma Membrane External Side Of Plasma Membrane Membrane Integral Component Of Membrane Intrinsic Component Of Endosome Membrane Vesicle Weibel-Palade Body Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Hormone Activity Protein Binding Calcitonin Receptor Binding Identical Protein Binding	Endopeptidase Activity Metalloendopeptidase Activity Protein Binding Zinc Ion Binding Peptide Hormone Binding Protein Homodimerization Activity
	Biological Process	Artery Vasodilation Involved In Baroreceptor Response To Increased Systemic Arterial Blood Pressure Monocyte Chemotaxis Inflammatory Response G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Neuropeptide Signaling Pathway Embryo Implantation Aging Feeding Behavior Regulation Of Heart Contraction Response To Heat Negative Regulation Of Ossification Activation Of Protein Kinase Activity Cellular Protein Metabolic Process Negative Regulation Of Bone Resorption Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Smooth Muscle Contraction Response To Pain Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway Cellular Response To Tumor Necrosis Factor Cellular Response To Nerve Growth Factor Stimulus	Positive Regulation Of Receptor Recycling Regulation Of Systemic Arterial Blood Pressure By Endothelin Heart Development Substance P Catabolic Process Bradykinin Catabolic Process Calcitonin Catabolic Process Protein Processing Peptide Hormone Processing Regulation Of Vasoconstriction Endothelin Maturation Hormone Catabolic Process Embryonic Digit Morphogenesis Ear Development
Pathways		G alpha (s) signalling events Calcitonin-like ligand receptors ADORA2B mediated anti-inflammatory cytokines production Amyloid fiber formation G alpha (s) signalling events Calcitonin-like ligand receptors ADORA2B mediated anti-inflammatory cytokines production	Peptide ligand-binding receptors
Drugs		Olcegepant Telcagepant Eptinezumab Fremanezumab Galcanezumab	5-(2-hydroxyethyl)nonane-1,9-diol
Diseases
GWAS		Diverticular disease ( 30177863) Vitamin D levels ( 25208829)	Body mass index ( 28552196) Body size at age 10 ( 32376654) Feeling worry ( 29500382) Height ( 25282103) Longevity (age >90th survival percentile) ( 31413261) Morning person ( 30696823) Obesity-related traits ( 23251661) Weight ( 28552196)
Interacting Genes		8 interacting genes: ANKRD11 BBS1 BBS4 CALCRL ECE1 NRDC RAMP1 RAMP2	14 interacting genes: AGT CALCA CLK1 CLK2 CYSRT1 EDN1 KNG1 KRTAP1-3 KRTAP10-1 KRTAP10-5 KRTAP10-8 MTDH MTNR1A MYOC
Entrez ID		796	1889
HPRD ID		00238	02690
Ensembl ID		ENSG00000110680	ENSG00000117298
Uniprot IDs		P01258 P06881	A0A024RAB0 A0A024RAB2 A1PUP8 P42892
PDB IDs		1LS7 2JXZ 6E3Y	3DWB
Enriched GO Terms of Interacting Partners?
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