EPM2A and COX5A

Data Source:
BioGRID (two hybrid)

		EPM2A	COX5A
Description		EPM2A glucan phosphatase, laforin	cytochrome c oxidase subunit 5A
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GO Annotations	Cellular Component	Nucleus	Mitochondrial Inner Membrane Mitochondrial Respiratory Chain Complex IV
	Molecular Function	Protein Binding	Cytochrome-c Oxidase Activity Protein Binding Electron Transfer Activity Metal Ion Binding
	Biological Process	Positive Regulation Of Macroautophagy Negative Regulation Of TOR Signaling	Mitochondrial Electron Transport, Cytochrome C To Oxygen Proton Transmembrane Transport
Pathways		Glycogen synthesis Myoclonic epilepsy of Lafora	TP53 Regulates Metabolic Genes Respiratory electron transport
Drugs			Cholic Acid N-Formylmethionine
Diseases		Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD)
GWAS		Loneliness (multivariate analysis) ( 27629369) Mean platelet volume ( 32888494 27863252) Methadone dose in opioid dependence ( 28115739) Response to mepolizumab in severe asthma ( 29229094)	Caffeine consumption ( 21490707) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Neutrophil percentage of white cells ( 32888494) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)
Interacting Genes		16 interacting genes: COX5A EIF2B1 EPM2AIP1 HMGXB4 NFU1 NHLRC1 PKM PPP1R3C PPP1R3D PRKAA1 PRKAA2 PRKAB2 PSMC3 SRPK2 TDG TOPORS	9 interacting genes: COPS6 EPM2A EXOSC8 HTRA1 KRT31 KRT40 MESD MT-CO1 SPDEF
Entrez ID		7957	9377
HPRD ID		06345	04799
Ensembl ID		ENSG00000112425	ENSG00000178741
Uniprot IDs		H0UI04 O95278	P20674
PDB IDs		4R30 4RKK	5Z62
Enriched GO Terms of Interacting Partners?
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