EPM2A and NHLRC1

Data Source:
BioGRID (pull down, affinity chromatography technology, two hybrid)

		EPM2A	NHLRC1
Description		EPM2A glucan phosphatase, laforin	NHL repeat containing E3 ubiquitin protein ligase 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus	Nucleus Endoplasmic Reticulum Cytosol Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding	Ubiquitin-protein Transferase Activity Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Positive Regulation Of Macroautophagy Negative Regulation Of TOR Signaling	Protein Polyubiquitination Glycogen Biosynthetic Process Autophagy Regulation Of Gene Expression Positive Regulation Of Protein Ubiquitination Response To Endoplasmic Reticulum Stress Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Kinase Activity Regulation Of Protein Localization To Plasma Membrane
Pathways		Glycogen synthesis Myoclonic epilepsy of Lafora	Glycogen synthesis Myoclonic epilepsy of Lafora
Drugs
Diseases		Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD)	Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD)
GWAS		Loneliness (multivariate analysis) ( 27629369) Mean platelet volume ( 32888494 27863252) Methadone dose in opioid dependence ( 28115739) Response to mepolizumab in severe asthma ( 29229094)	Intrinsic epigenetic age acceleration ( 29374233)
Interacting Genes		16 interacting genes: COX5A EIF2B1 EPM2AIP1 HMGXB4 NFU1 NHLRC1 PKM PPP1R3C PPP1R3D PRKAA1 PRKAA2 PRKAB2 PSMC3 SRPK2 TDG TOPORS	9 interacting genes: AGL EPM2A GYS1 NNAT PPP1R3C UBE2D1 UBE2D3 UBE2E1 UBE2H
Entrez ID		7957	378884
HPRD ID		06345	06995
Ensembl ID		ENSG00000112425	ENSG00000187566
Uniprot IDs		H0UI04 O95278	Q6VVB1
PDB IDs		4R30 4RKK
Enriched GO Terms of Interacting Partners?
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