MAIP1 and APOC4

Data Source:
BioGRID (two hybrid)

		MAIP1	APOC4
Description		matrix AAA peptidase interacting protein 1	apolipoprotein C4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Mitochondrial Inner Membrane Mitochondrial Matrix	Extracellular Region Very-low-density Lipoprotein Particle High-density Lipoprotein Particle
	Molecular Function	Protein Binding Ribosome Binding	Lipid Transporter Activity Protein Binding
	Biological Process	Mitochondrial Calcium Ion Transmembrane Transport Inner Mitochondrial Membrane Organization Protein Insertion Into Mitochondrial Inner Membrane From Matrix Calcium Import Into The Mitochondrion Protein Insertion Into Mitochondrial Membrane Mitochondrial Calcium Ion Homeostasis	Lipid Metabolic Process Lipid Transport Positive Regulation Of Sequestering Of Triglyceride Very-low-density Lipoprotein Particle Assembly Very-low-density Lipoprotein Particle Clearance Triglyceride Homeostasis
Pathways		Processing of SMDT1	VLDL assembly VLDL clearance VLDL clearance NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
Drugs
Diseases
GWAS		Bipolar disorder lithium response (continuous) or schizophrenia ( 29121268) Sleep duration ( 30846698)	Alzheimer's disease (onset between ages 58 and 79) ( 30979435) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Apolipoprotein A1 levels ( 32203549) Blood protein levels ( 29875488 28240269) Carotid intima media thickness (maximum) ( 31801372) Carotid intima media thickness (mean) ( 31801372) Cerebrospinal AB1-42 levels in Alzheimer's disease dementia ( 29274321) Cerebrospinal AB1-42 levels in mild cognitive impairment ( 29274321) Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Cerebrospinal fluid AB1-42 levels ( 29274321) Cerebrospinal fluid p-tau levels ( 29274321) Cerebrospinal fluid p-tau levels in mild cognitive impairment ( 29274321) Cerebrospinal fluid t-tau levels ( 29274321) Cerebrospinal fluid t-tau levels in mild cognitive impairment ( 29274321) HDL cholesterol levels ( 32203549) Hippocampal volume ( 29274321) Hippocampal volume in Alzheimer's disease dementia ( 29274321) LDL cholesterol ( 18802019 18193043 18193044 20864672 19060906) Logical memory (delayed recall) ( 29274321) Logical memory (immediate recall) ( 29274321) Quantitative traits ( 19197348) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659)
Interacting Genes		5 interacting genes: APOC1 APOC2 APOC4 APP H4C7	24 interacting genes: APOL2 BCL2L2 DIABLO GAD2 GSDMA IFI27 LETMD1 MAIP1 MICOS10 MICOS13 NFU1 PORCN RSAD2 SENP2 SNAP47 SYT16 TBC1D20 THBD TIMMDC1 TMEM14B TPRG1 UBQLN1 UBQLN2 VKORC1
Entrez ID		79568	346
HPRD ID		07994	02848
Ensembl ID		ENSG00000162972	ENSG00000267467
Uniprot IDs		A0A024R3U8 Q8WWC4	P55056
PDB IDs
Enriched GO Terms of Interacting Partners?
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