APOC4 and RSAD2

Data Source:
BioGRID (two hybrid)

		APOC4	RSAD2
Description		apolipoprotein C4	radical S-adenosyl methionine domain containing 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Very-low-density Lipoprotein Particle High-density Lipoprotein Particle	Fibrillar Center Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Lipid Droplet
	Molecular Function	Lipid Transporter Activity Protein Binding	Catalytic Activity Protein Binding Protein Self-association Metal Ion Binding 4 Iron, 4 Sulfur Cluster Binding
	Biological Process	Lipid Metabolic Process Lipid Transport Positive Regulation Of Sequestering Of Triglyceride Very-low-density Lipoprotein Particle Assembly Very-low-density Lipoprotein Particle Clearance Triglyceride Homeostasis	Response To Virus Viral Process Positive Regulation Of Toll-like Receptor 7 Signaling Pathway Positive Regulation Of Toll-like Receptor 9 Signaling Pathway CD4-positive, Alpha-beta T Cell Activation CD4-positive, Alpha-beta T Cell Differentiation Negative Regulation Of Viral Genome Replication Negative Regulation Of Protein Secretion Positive Regulation Of Immune Response Defense Response To Virus Type I Interferon Signaling Pathway Positive Regulation Of T-helper 2 Cell Cytokine Production
Pathways		VLDL assembly VLDL clearance VLDL clearance NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	Interferon alpha/beta signaling
Drugs
Diseases
GWAS		Alzheimer's disease (onset between ages 58 and 79) ( 30979435) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Apolipoprotein A1 levels ( 32203549) Blood protein levels ( 29875488 28240269) Carotid intima media thickness (maximum) ( 31801372) Carotid intima media thickness (mean) ( 31801372) Cerebrospinal AB1-42 levels in Alzheimer's disease dementia ( 29274321) Cerebrospinal AB1-42 levels in mild cognitive impairment ( 29274321) Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Cerebrospinal fluid AB1-42 levels ( 29274321) Cerebrospinal fluid p-tau levels ( 29274321) Cerebrospinal fluid p-tau levels in mild cognitive impairment ( 29274321) Cerebrospinal fluid t-tau levels ( 29274321) Cerebrospinal fluid t-tau levels in mild cognitive impairment ( 29274321) HDL cholesterol levels ( 32203549) Hippocampal volume ( 29274321) Hippocampal volume in Alzheimer's disease dementia ( 29274321) LDL cholesterol ( 18802019 18193043 18193044 20864672 19060906) Logical memory (delayed recall) ( 29274321) Logical memory (immediate recall) ( 29274321) Quantitative traits ( 19197348) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659)
Interacting Genes		24 interacting genes: APOL2 BCL2L2 DIABLO GAD2 GSDMA IFI27 LETMD1 MAIP1 MICOS10 MICOS13 NFU1 PORCN RSAD2 SENP2 SNAP47 SYT16 TBC1D20 THBD TIMMDC1 TMEM14B TPRG1 UBQLN1 UBQLN2 VKORC1	6 interacting genes: APOC1 APOC2 APOC4 RHBDD2 UBE2D1 UBE4A
Entrez ID		346	91543
HPRD ID		02848	07423
Ensembl ID		ENSG00000267467	ENSG00000134321
Uniprot IDs		P55056	Q8WXG1
PDB IDs
Enriched GO Terms of Interacting Partners?
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