APOC4 and GSDMA

Data Source:
BioGRID (two hybrid)

		APOC4	GSDMA
Description		apolipoprotein C4	gasdermin A
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Very-low-density Lipoprotein Particle High-density Lipoprotein Particle	Cytosol Plasma Membrane Integral Component Of Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Lipid Transporter Activity Protein Binding	Phosphatidylserine Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-4-phosphate Binding
	Biological Process	Lipid Metabolic Process Lipid Transport Positive Regulation Of Sequestering Of Triglyceride Very-low-density Lipoprotein Particle Assembly Very-low-density Lipoprotein Particle Clearance Triglyceride Homeostasis	Apoptotic Process Defense Response To Bacterium Pyroptosis
Pathways		VLDL assembly VLDL clearance VLDL clearance NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
Drugs
Diseases
GWAS		Alzheimer's disease (onset between ages 58 and 79) ( 30979435) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Apolipoprotein A1 levels ( 32203549) Blood protein levels ( 29875488 28240269) Carotid intima media thickness (maximum) ( 31801372) Carotid intima media thickness (mean) ( 31801372) Cerebrospinal AB1-42 levels in Alzheimer's disease dementia ( 29274321) Cerebrospinal AB1-42 levels in mild cognitive impairment ( 29274321) Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Cerebrospinal fluid AB1-42 levels ( 29274321) Cerebrospinal fluid p-tau levels ( 29274321) Cerebrospinal fluid p-tau levels in mild cognitive impairment ( 29274321) Cerebrospinal fluid t-tau levels ( 29274321) Cerebrospinal fluid t-tau levels in mild cognitive impairment ( 29274321) HDL cholesterol levels ( 32203549) Hippocampal volume ( 29274321) Hippocampal volume in Alzheimer's disease dementia ( 29274321) LDL cholesterol ( 18802019 18193043 18193044 20864672 19060906) Logical memory (delayed recall) ( 29274321) Logical memory (immediate recall) ( 29274321) Quantitative traits ( 19197348) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659)	Asthma ( 31959851 20860503 31619474 29785011) Asthma (childhood onset) ( 24241537) Asthma (time to onset) ( 27130862) Asthma and hay fever ( 24388013) Asthma or allergic disease (pleiotropy) ( 29785011) Bipolar disorder ( 31043756) Bronchial hyperresponsiveness in asthma ( 27439200) Crohn's disease ( 28067908) Hematological parameters ( 19820697) Inflammatory bowel disease ( 28067908 23128233) Lymphocyte percentage of white cells ( 32888494) Refractive error ( 32231278) Systemic sclerosis ( 28314753) Ulcerative colitis ( 28067908) White blood cell count ( 22037903 20139978 21738480)
Interacting Genes		24 interacting genes: APOL2 BCL2L2 DIABLO GAD2 GSDMA IFI27 LETMD1 MAIP1 MICOS10 MICOS13 NFU1 PORCN RSAD2 SENP2 SNAP47 SYT16 TBC1D20 THBD TIMMDC1 TMEM14B TPRG1 UBQLN1 UBQLN2 VKORC1	3 interacting genes: APOC1 APOC2 APOC4
Entrez ID		346	284110
HPRD ID		02848	17081
Ensembl ID		ENSG00000267467	ENSG00000167914
Uniprot IDs		P55056	Q96QA5
PDB IDs
Enriched GO Terms of Interacting Partners?
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