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NELFE and SRPK1
Data Source:
BioGRID
(enzymatic study)
NELFE
SRPK1
Description
negative elongation factor complex member E
SRSF protein kinase 1
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Plasma Membrane
Nuclear Body
NELF Complex
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Endoplasmic Reticulum
Cytosol
Plasma Membrane
Nuclear Matrix
Nuclear Speck
Molecular Function
Chromatin Binding
RNA Binding
Protein Binding
Magnesium Ion Binding
RNA Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Transcription By RNA Polymerase II
Transcription Elongation From RNA Polymerase II Promoter
Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Viral Transcription
Positive Regulation Of Histone H3-K4 Methylation
Positive Regulation Of ERK1 And ERK2 Cascade
Negative Regulation Of MRNA Polyadenylation
MAPK Cascade
Spliceosomal Complex Assembly
Protein Phosphorylation
Chromosome Segregation
RNA Splicing
Viral Process
Sperm Chromatin Condensation
Intracellular Signal Transduction
Positive Regulation Of Viral Genome Replication
Negative Regulation Of Viral Genome Replication
Innate Immune Response
Regulation Of MRNA Splicing, Via Spliceosome
Regulation Of MRNA Processing
Pathways
Formation of RNA Pol II elongation complex
Formation of the Early Elongation Complex
Formation of HIV elongation complex in the absence of HIV Tat
Formation of the HIV-1 Early Elongation Complex
Formation of HIV-1 elongation complex containing HIV-1 Tat
Formation of HIV-1 elongation complex containing HIV-1 Tat
Pausing and recovery of Tat-mediated HIV elongation
Abortive elongation of HIV-1 transcript in the absence of Tat
Tat-mediated HIV elongation arrest and recovery
Tat-mediated elongation of the HIV-1 transcript
HIV elongation arrest and recovery
Pausing and recovery of HIV elongation
RNA Polymerase II Pre-transcription Events
TP53 Regulates Transcription of DNA Repair Genes
RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS
Asthma (
31619474
)
Autism spectrum disorder or schizophrenia (
28540026
)
Blood protein levels (
28240269
)
Coronary artery disease (
29212778
)
Disease progression in age-related macular degeneration (
29346644
)
Inflammatory bowel disease (
28067908
)
Ulcerative colitis (
28067908
)
vWF levels (
30586737
)
Antidepressant treatment resistance (> 2 drugs prescribed) (
30700811
)
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
)
Mean reticulocyte volume (
32888494
)
Interacting Genes
10 interacting genes:
CACTIN
CCDC57
MTUS2
NCOR1
NELFB
SRPK1
SRPK2
TNKS
TRIM27
VAMP3
170 interacting genes:
ADPRH
AHCYL1
ALKBH3
AMMECR1L
APEX1
APP
ARGLU1
ARHGAP12
ARHGAP26
ASAH1
ASXL1
AURKA
AURKC
C11orf52
C11orf87
C16orf78
C18orf25
C9orf72
CACNB1
CAMK2D
CBX5
CDC42EP3
CDK7
CDKL3
CHEK2
CHERP
CHUK
CIAO1
CLIC5
CLK1
CLK4
CRHR1
CSAG1
DAW1
DDX47
DHX8
DHX9
DNAJC8
DUSP6
ECM1
EIF3M
EPB41L4A
EPHA3
ERBB2
ESRRG
FAM124A
FAM76B
FERMT1
FGF12
FHL1
FKBP3
FLOT1
FLT1
GABARAP
GABARAPL1
HBS1L
HIRIP3
HMGN3
HNRNPA1
IFIT5
IKBKG
JHY
KCNAB1
KCNN2
KIAA1841
KPNA2
KPTN
KRR1
LAMC1
LARP1
LBR
LCE3D
LIMK1
LINC00312
LUC7L3
MACROH2A1
MAGEB1
MAOB
MAP1LC3A
MAPK12
MAPK14
MAPKAPK5
MAPT
MBNL3
MBP
MRPL43
MRPS11
NCK2
NELFE
NKAP
NOL4L
NOP16
NOVA1
NSMCE4A
NSRP1
NUDT21
NXT2
OCEL1
ODF3L2
OR6B3
PAK4
PDGFRA
PDPK1
PELI1
PELI2
PEX19
PFN1
PHF7
POLR2E
PPIA
PPIL1
PRM1
PRPF38A
PTK2
RBM23
RBM39
RBM8A
RBMS2
RIMS4
RNPS1
RPS6KB2
RSRC1
RSRC2
RSRP1
SAFB
SCAF11
SEC23B
SERPINB10
SETD3
SFMBT1
SLAIN2
SLC4A1AP
SNRNP70
SPANXN4
SPATS2
SREK1
SRPK3
SRRM1
SRSF1
SRSF12
SRSF3
SRSF4
SRSF5
SRSF6
SRSF7
SRSF8
STAU1
STK26
SUDS3
TAF1B
TFEB
TNFRSF10C
TOP2A
TRA2B
TRIM65
U2AF1
U2AF2
UBD
UBE2E2
USP39
VANGL1
VDR
WDR55
YPEL2
YTHDC1
YWHAG
ZMYND11
ZNF444
ZNF514
ZRANB2
Entrez ID
7936
6732
HPRD ID
01096
15992
Ensembl ID
ENSG00000204356
ENSG00000096063
Uniprot IDs
A0A1U9X830
P18615
Q96SB4
PDB IDs
1X5P
2BZ2
2JX2
5OOB
6GML
1WAK
1WBP
3BEG
4WUA
5MXX
5MY8
5NNG
5XV7
6FAD
Enriched GO Terms of Interacting Partners
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