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SRPK1 and NCK2
Data Source:
BioGRID
(enzymatic study)
SRPK1
NCK2
Description
SRSF protein kinase 1
NCK adaptor protein 2
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Endoplasmic Reticulum
Cytosol
Plasma Membrane
Nuclear Matrix
Nuclear Speck
Cytoplasm
Endoplasmic Reticulum
Cytosol
Vesicle Membrane
Postsynaptic Density
Molecular Function
Magnesium Ion Binding
RNA Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
Phosphotyrosine Residue Binding
Protein Binding
Cytoskeletal Anchor Activity
Signaling Receptor Complex Adaptor Activity
Signaling Adaptor Activity
Protein-containing Complex Binding
Scaffold Protein Binding
Biological Process
MAPK Cascade
Spliceosomal Complex Assembly
Protein Phosphorylation
Chromosome Segregation
RNA Splicing
Viral Process
Sperm Chromatin Condensation
Intracellular Signal Transduction
Positive Regulation Of Viral Genome Replication
Negative Regulation Of Viral Genome Replication
Innate Immune Response
Regulation Of MRNA Splicing, Via Spliceosome
Regulation Of MRNA Processing
Immunological Synapse Formation
Actin Filament Organization
Signal Transduction
Signal Complex Assembly
Epidermal Growth Factor Receptor Signaling Pathway
Regulation Of Epidermal Growth Factor-activated Receptor Activity
Negative Regulation Of Cell Population Proliferation
Cell Migration
Lamellipodium Assembly
Positive Regulation Of Actin Filament Polymerization
Negative Regulation Of Peptidyl-serine Phosphorylation
Positive Regulation Of Translation In Response To Endoplasmic Reticulum Stress
Positive Regulation Of T Cell Proliferation
T Cell Activation
Positive Regulation Of Transcription By RNA Polymerase II
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Ephrin Receptor Signaling Pathway
Dendritic Spine Development
Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway
Negative Regulation Of PERK-mediated Unfolded Protein Response
Negative Regulation Of Endoplasmic Reticulum Stress-induced EIF2 Alpha Phosphorylation
Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress
Pathways
Downstream signal transduction
Nephrin family interactions
Ephrin signaling
Activation of RAC1
VEGFA-VEGFR2 Pathway
Regulation of cortical dendrite branching
Drugs
Diseases
GWAS
Antidepressant treatment resistance (> 2 drugs prescribed) (
30700811
)
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
)
Mean reticulocyte volume (
32888494
)
Addiction (
23533358
)
Anti-chlamydia trachomatis IgG seropositivity (
33204752
)
Mean platelet volume (
32888494
)
Platelet distribution width (
32888494
27863252
)
Systolic blood pressure in sickle cell anemia (
24058526
)
Interacting Genes
170 interacting genes:
ADPRH
AHCYL1
ALKBH3
AMMECR1L
APEX1
APP
ARGLU1
ARHGAP12
ARHGAP26
ASAH1
ASXL1
AURKA
AURKC
C11orf52
C11orf87
C16orf78
C18orf25
C9orf72
CACNB1
CAMK2D
CBX5
CDC42EP3
CDK7
CDKL3
CHEK2
CHERP
CHUK
CIAO1
CLIC5
CLK1
CLK4
CRHR1
CSAG1
DAW1
DDX47
DHX8
DHX9
DNAJC8
DUSP6
ECM1
EIF3M
EPB41L4A
EPHA3
ERBB2
ESRRG
FAM124A
FAM76B
FERMT1
FGF12
FHL1
FKBP3
FLOT1
FLT1
GABARAP
GABARAPL1
HBS1L
HIRIP3
HMGN3
HNRNPA1
IFIT5
IKBKG
JHY
KCNAB1
KCNN2
KIAA1841
KPNA2
KPTN
KRR1
LAMC1
LARP1
LBR
LCE3D
LIMK1
LINC00312
LUC7L3
MACROH2A1
MAGEB1
MAOB
MAP1LC3A
MAPK12
MAPK14
MAPKAPK5
MAPT
MBNL3
MBP
MRPL43
MRPS11
NCK2
NELFE
NKAP
NOL4L
NOP16
NOVA1
NSMCE4A
NSRP1
NUDT21
NXT2
OCEL1
ODF3L2
OR6B3
PAK4
PDGFRA
PDPK1
PELI1
PELI2
PEX19
PFN1
PHF7
POLR2E
PPIA
PPIL1
PRM1
PRPF38A
PTK2
RBM23
RBM39
RBM8A
RBMS2
RIMS4
RNPS1
RPS6KB2
RSRC1
RSRC2
RSRP1
SAFB
SCAF11
SEC23B
SERPINB10
SETD3
SFMBT1
SLAIN2
SLC4A1AP
SNRNP70
SPANXN4
SPATS2
SREK1
SRPK3
SRRM1
SRSF1
SRSF12
SRSF3
SRSF4
SRSF5
SRSF6
SRSF7
SRSF8
STAU1
STK26
SUDS3
TAF1B
TFEB
TNFRSF10C
TOP2A
TRA2B
TRIM65
U2AF1
U2AF2
UBD
UBE2E2
USP39
VANGL1
VDR
WDR55
YPEL2
YTHDC1
YWHAG
ZMYND11
ZNF444
ZNF514
ZRANB2
171 interacting genes:
ABI1
ABI2
ABI3
ANKRD55
ANKS1B
ARHGAP32
ATN1
AXIN1
AXL
BCAR1
BCL11A
BTG1
C4orf17
CBARP
CBLB
CCDC120
CCDC33
CD3E
CHN1
CHN2
CIB1
CIPC
CLEC17A
CPSF6
CPSF7
CUEDC1
DDR1
DEFB124
DISC1
DLGAP4
DNM1
DOCK1
DOK1
DRAP1
DTX3
DVL1
EEF1G
EFHC2
EFNB1
EFNB2
EFS
EGFR
EIF3H
ERBB2
ERBB3
ERBB4
FAM124A
FAM47A
FAM53C
FAM83A
FASLG
FBXL19
FCRL2
FGFR1
FOSB
FXR2
FYB1
GAB1
GAREM1
GGN
HNRNPK
HOMEZ
HOXA1
HOXC4
HOXD8
HSF2BP
ILK
INCA1
INTS2
IRS1
KCTD17
KHDRBS1
KIAA0408
KIAA1217
KIT
KLHL24
KLHL35
KPRP
LCP2
LIMS1
LNX1
LRRIQ3
LZTS2
MAGEA6
MASP1
MBD6
MEOX2
MET
MIA3
MNT
MYPOP
NCKIPSD
NELFA
NET1
NFKBID
NHSL2
NPAS2
NPHS1
NR5A1
NTRK2
NUTM2F
ONECUT3
PAK1
PAK2
PBX4
PDGFRB
PHETA1
PIK3AP1
PKD1
PKN2
PRDM6
PRR16
PRR20A
PRR20B
PRR20C
PRR20D
PRR20E
PSMD10
PTK2
RASSF7
RBBP8NL
RBM26
REEP4
REL
SCML2
SCX
SF1
SF3A2
SF3B4
SHD
SKAP2
SMARCB1
SNW1
SOCS7
SORBS2
SOS1
SPATA2L
SPATC1L
SPRY2
SRMS
SRPK1
SRPK2
SSH3
SYNGAP1
SYNPO
TCF4
TCP10L
TMEM121
TNR
TRIM27
TRIM41
TRIP6
TXK
UBC
USP32
VARS2
VPS37B
WAS
WASF1
WASL
WBP11
WIPF1
WIPF2
ZBTB12
ZBTB42
ZBTB7B
ZC2HC1A
ZC2HC1B
ZNF341
ZNF526
ZNF688
Entrez ID
6732
8440
HPRD ID
15992
05378
Ensembl ID
ENSG00000096063
ENSG00000071051
Uniprot IDs
Q96SB4
A0A0S2Z4M6
E7ERP6
O43639
PDB IDs
1WAK
1WBP
3BEG
4WUA
5MXX
5MY8
5NNG
5XV7
6FAD
1U5S
1WX6
1Z3K
2B86
2CIA
2FRW
2FRY
2JXB
4E6R
Enriched GO Terms of Interacting Partners
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