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SRPK1 and PDPK1
Data Source:
BioGRID
(enzymatic study)
SRPK1
PDPK1
Description
SRSF protein kinase 1
3-phosphoinositide dependent protein kinase 1
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Endoplasmic Reticulum
Cytosol
Plasma Membrane
Nuclear Matrix
Nuclear Speck
Nucleus
Cytoplasm
Cytosol
Plasma Membrane
Focal Adhesion
Postsynaptic Density
Membrane
Cytoplasmic Vesicle
Cell Projection
Perikaryon
Molecular Function
Magnesium Ion Binding
RNA Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
Protein Serine/threonine Kinase Activity
3-phosphoinositide-dependent Protein Kinase Activity
Insulin Receptor Binding
Protein Binding
ATP Binding
Phospholipase Activator Activity
Protein Kinase Binding
Phospholipase Binding
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
Biological Process
MAPK Cascade
Spliceosomal Complex Assembly
Protein Phosphorylation
Chromosome Segregation
RNA Splicing
Viral Process
Sperm Chromatin Condensation
Intracellular Signal Transduction
Positive Regulation Of Viral Genome Replication
Negative Regulation Of Viral Genome Replication
Innate Immune Response
Regulation Of MRNA Splicing, Via Spliceosome
Regulation Of MRNA Processing
Stimulatory C-type Lectin Receptor Signaling Pathway
Type B Pancreatic Cell Development
Protein Phosphorylation
Negative Regulation Of Protein Kinase Activity
Hyperosmotic Response
Epidermal Growth Factor Receptor Signaling Pathway
Positive Regulation Of Phospholipase Activity
Negative Regulation Of Cardiac Muscle Cell Apoptotic Process
Cell Migration
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Calcium-mediated Signaling
Actin Cytoskeleton Organization
Platelet Activation
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
T Cell Costimulation
Activation Of Protein Kinase B Activity
Cellular Response To Insulin Stimulus
Negative Regulation Of Toll-like Receptor Signaling Pathway
Intracellular Signal Transduction
Fc-epsilon Receptor Signaling Pathway
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Regulation Of Mast Cell Degranulation
Negative Regulation Of Neuron Apoptotic Process
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Positive Regulation Of Angiogenesis
Protein Autophosphorylation
Focal Adhesion Assembly
T Cell Receptor Signaling Pathway
Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Cellular Response To Epidermal Growth Factor Stimulus
Extrinsic Apoptotic Signaling Pathway
Positive Regulation Of Protein Localization To Plasma Membrane
Positive Regulation Of Sprouting Angiogenesis
Positive Regulation Of Vascular Endothelial Cell Proliferation
Cellular Response To Brain-derived Neurotrophic Factor Stimulus
Negative Regulation Of Endothelial Cell Apoptotic Process
Pathways
GPVI-mediated activation cascade
GPVI-mediated activation cascade
PIP3 activates AKT signaling
Activation of AKT2
Downstream TCR signaling
Role of LAT2/NTAL/LAB on calcium mobilization
FCERI mediated NF-kB activation
Integrin signaling
CD28 dependent PI3K/Akt signaling
G beta:gamma signalling through PI3Kgamma
RSK activation
VEGFR2 mediated vascular permeability
VEGFR2 mediated cell proliferation
CLEC7A (Dectin-1) signaling
RHO GTPases activate PKNs
Constitutive Signaling by AKT1 E17K in Cancer
Regulation of TP53 Degradation
Estrogen-stimulated signaling through PRKCZ
Estrogen-stimulated signaling through PRKCZ
Drugs
Celecoxib
Inositol 1,3,4,5-Tetrakisphosphate
7-Hydroxystaurosporine
Bisindolylmaleimide VIII
Staurosporine
Bisindolylmaleimide I
Dexfosfoserine
10,11-dimethoxy-4-methyldibenzo[c,f]-2,7-naphthyridine-3,6-diamine
5-HYDROXY-3-[(1R)-1-(1H-PYRROL-2-YL)ETHYL]-2H-INDOL-2-ONE
1-{2-OXO-3-[(1R)-1-(1H-PYRROL-2-YL)ETHYL]-2H-INDOL-5-YL}UREA
2-(1H-imidazol-1-yl)-9-methoxy-8-(2-methoxyethoxy)benzo[c][2,7]naphthyridin-4-amine
3-(1H-indol-3-yl)-4-(1-{2-[(2S)-1-methylpyrrolidinyl]ethyl}-1H-indol-3-yl)-1H-pyrrole-2,5-dione
3-[1-(3-AMINOPROPYL)-1H-INDOL-3-YL]-4-(1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE
Fostamatinib
Diseases
GWAS
Antidepressant treatment resistance (> 2 drugs prescribed) (
30700811
)
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
)
Mean reticulocyte volume (
32888494
)
Interacting Genes
170 interacting genes:
ADPRH
AHCYL1
ALKBH3
AMMECR1L
APEX1
APP
ARGLU1
ARHGAP12
ARHGAP26
ASAH1
ASXL1
AURKA
AURKC
C11orf52
C11orf87
C16orf78
C18orf25
C9orf72
CACNB1
CAMK2D
CBX5
CDC42EP3
CDK7
CDKL3
CHEK2
CHERP
CHUK
CIAO1
CLIC5
CLK1
CLK4
CRHR1
CSAG1
DAW1
DDX47
DHX8
DHX9
DNAJC8
DUSP6
ECM1
EIF3M
EPB41L4A
EPHA3
ERBB2
ESRRG
FAM124A
FAM76B
FERMT1
FGF12
FHL1
FKBP3
FLOT1
FLT1
GABARAP
GABARAPL1
HBS1L
HIRIP3
HMGN3
HNRNPA1
IFIT5
IKBKG
JHY
KCNAB1
KCNN2
KIAA1841
KPNA2
KPTN
KRR1
LAMC1
LARP1
LBR
LCE3D
LIMK1
LINC00312
LUC7L3
MACROH2A1
MAGEB1
MAOB
MAP1LC3A
MAPK12
MAPK14
MAPKAPK5
MAPT
MBNL3
MBP
MRPL43
MRPS11
NCK2
NELFE
NKAP
NOL4L
NOP16
NOVA1
NSMCE4A
NSRP1
NUDT21
NXT2
OCEL1
ODF3L2
OR6B3
PAK4
PDGFRA
PDPK1
PELI1
PELI2
PEX19
PFN1
PHF7
POLR2E
PPIA
PPIL1
PRM1
PRPF38A
PTK2
RBM23
RBM39
RBM8A
RBMS2
RIMS4
RNPS1
RPS6KB2
RSRC1
RSRC2
RSRP1
SAFB
SCAF11
SEC23B
SERPINB10
SETD3
SFMBT1
SLAIN2
SLC4A1AP
SNRNP70
SPANXN4
SPATS2
SREK1
SRPK3
SRRM1
SRSF1
SRSF12
SRSF3
SRSF4
SRSF5
SRSF6
SRSF7
SRSF8
STAU1
STK26
SUDS3
TAF1B
TFEB
TNFRSF10C
TOP2A
TRA2B
TRIM65
U2AF1
U2AF2
UBD
UBE2E2
USP39
VANGL1
VDR
WDR55
YPEL2
YTHDC1
YWHAG
ZMYND11
ZNF444
ZNF514
ZRANB2
60 interacting genes:
AKT1
AKT2
AKT3
AKTIP
APBB3
APP
BLMH
CARD11
CDAN1
CSK
DDIT4
GIT1
HSP90AA1
ILK
IRS1
ITGB3
KATNBL1
LUC7L2
MAPK8
MTOR
PAK1
PEA15
PHAX
PKN1
PKN2
PNO1
POLDIP2
PRKACA
PRKCB
PRKCD
PRKCE
PRKCI
PRKCZ
PRSS23
PRXL2B
PTK2B
PXN
RALGDS
RPS6KA1
RPS6KA3
RPS6KB1
RPS6KB2
SBF1
SGK1
SGK2
SGK3
SLC9A3R2
SMARCB1
SOCS3
SRC
SRPK1
STRAP
TCAP
WDCP
XPO7
XRCC6
YWHAH
YWHAQ
ZC3HC1
ZNF133
Entrez ID
6732
5170
HPRD ID
15992
05556
Ensembl ID
ENSG00000096063
ENSG00000140992
Uniprot IDs
Q96SB4
O15530
PDB IDs
1WAK
1WBP
3BEG
4WUA
5MXX
5MY8
5NNG
5XV7
6FAD
1H1W
1OKY
1OKZ
1UU3
1UU7
1UU8
1UU9
1UVR
1W1D
1W1G
1W1H
1Z5M
2BIY
2PE0
2PE1
2PE2
2R7B
2VKI
2XCH
2XCK
3H9O
3HRC
3HRF
3ION
3IOP
3NAX
3NAY
3NUN
3NUS
3NUU
3NUY
3ORX
3ORZ
3OTU
3PWY
3QC4
3QCQ
3QCS
3QCX
3QCY
3QD0
3QD3
3QD4
3RCJ
3RWP
3RWQ
3SC1
4A06
4A07
4AW0
4AW1
4CT1
4CT2
4RQK
4RQV
4RRV
4XX9
5ACK
5HKM
5HNG
5HO7
5HO8
5LVL
5LVM
5LVN
5LVO
5LVP
5MRD
Enriched GO Terms of Interacting Partners
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