NELFE and CACTIN

Data Source:
BioGRID (two hybrid)

		NELFE	CACTIN
Description		negative elongation factor complex member E	cactin, spliceosome C complex subunit
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Plasma Membrane Nuclear Body NELF Complex	Nucleus Nucleoplasm Spliceosomal Complex Cytoplasm Cytosol Nuclear Speck Catalytic Step 2 Spliceosome
	Molecular Function	Chromatin Binding RNA Binding Protein Binding	RNA Binding Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Transcription Elongation From RNA Polymerase II Promoter Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Viral Transcription Positive Regulation Of Histone H3-K4 Methylation Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of MRNA Polyadenylation	MRNA Splicing, Via Spliceosome Negative Regulation Of Protein Phosphorylation Multicellular Organism Development Regulation Of Gene Expression Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Interferon-beta Production Negative Regulation Of Interleukin-8 Production Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Toll-like Receptor Signaling Pathway Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response MRNA Cis Splicing, Via Spliceosome Negative Regulation Of Innate Immune Response Negative Regulation Of Type I Interferon-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor
Pathways		Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Abortive elongation of HIV-1 transcript in the absence of Tat Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS		Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Coronary artery disease ( 29212778) Disease progression in age-related macular degeneration ( 29346644) Inflammatory bowel disease ( 28067908) Ulcerative colitis ( 28067908) vWF levels ( 30586737)
Interacting Genes		10 interacting genes: CACTIN CCDC57 MTUS2 NCOR1 NELFB SRPK1 SRPK2 TNKS TRIM27 VAMP3	4 interacting genes: CLK2 HMGB2 NELFE TRIM39
Entrez ID		7936	58509
HPRD ID		01096	18930
Ensembl ID		ENSG00000204356	ENSG00000105298
Uniprot IDs		A0A1U9X830 P18615	Q8WUQ7
PDB IDs		1X5P 2BZ2 2JX2 5OOB 6GML	6QDV
Enriched GO Terms of Interacting Partners?
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