CACNB3 and GEM

Data Source:
BioGRID (two hybrid)

		CACNB3	GEM
Description		calcium voltage-gated channel auxiliary subunit beta 3	GTP binding protein overexpressed in skeletal muscle
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Voltage-gated Calcium Channel Complex Membrane Apical Plasma Membrane Synapse L-type Voltage-gated Calcium Channel Complex	Nucleus Plasma Membrane Cytoplasmic Side Of Plasma Membrane Midbody Spindle Midzone Mitotic Spindle
	Molecular Function	Voltage-gated Calcium Channel Activity Calcium Channel Regulator Activity Protein Binding High Voltage-gated Calcium Channel Activity Protein Kinase Binding	Magnesium Ion Binding GTPase Activity Calcium Channel Regulator Activity Protein Binding Calmodulin Binding GTP Binding GDP Binding
	Biological Process	Calcium Ion Transport Chemical Synaptic Transmission Neuromuscular Junction Development T Cell Receptor Signaling Pathway Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Membrane Depolarization Calcium Ion Transport Into Cytosol Cardiac Conduction Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Protein Localization To Plasma Membrane Positive Regulation Of Protein Targeting To Membrane Cellular Response To Oxygen-glucose Deprivation Regulation Of Membrane Repolarization During Action Potential Regulation Of Voltage-gated Calcium Channel Activity Negative Regulation Of Voltage-gated Calcium Channel Activity Positive Regulation Of High Voltage-gated Calcium Channel Activity Regulation Of Membrane Hyperpolarization Negative Regulation Of Detection Of Mechanical Stimulus Involved In Sensory Perception Of Touch Positive Regulation Of Excitatory Postsynaptic Potential	Mitotic Cell Cycle Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Chromosome Organization Metaphase Plate Congression Negative Regulation Of High Voltage-gated Calcium Channel Activity
Pathways		Presynaptic depolarization and calcium channel opening Adrenaline,noradrenaline inhibits insulin secretion NCAM1 interactions Regulation of insulin secretion Regulation of insulin secretion
Drugs		Ergocalciferol Enflurane Ranolazine Phenytoin Topiramate Nimodipine Spironolactone Magnesium sulfate Levomenthol Miconazole Amiodarone Mibefradil Dronedarone Trimebutine Benidipine Cilnidipine Lacidipine Manidipine Butamben Bioallethrin Bioallethrin Fish oil
Diseases
GWAS			Carotid plaque burden ( 28282560) Coronary artery disease ( 29212778 33020668) Pulse pressure ( 30578418)
Interacting Genes		12 interacting genes: C20orf85 CACNA1B CACNA1C CEP76 CIAPIN1 CTBP2 FASLG GEM MEOX1 MTUS2 SKIV2L SYT1	128 interacting genes: A2M AHCYL1 ANKRD36B APOH ASB15 BEGAIN BHLHB9 BLOC1S2 BLZF1 BMP1 C1orf131 CACNB3 CALM1 CARD9 CCDC102B CCDC125 CCDC88B CDR2 CEP70 CLDN15 CLEC4G COG6 COG8 CTSL CYSRT1 DBF4B DEUP1 DISC1 ECSIT EFHC2 EXOSC8 GADD45GIP1 GAS8 GMIP GOLGA2 GOLGA6L9 GOPC HOOK2 HSF2BP IHO1 IKZF3 INCA1 INO80E INSC ISCA2 KATNBL1 KCTD9 KIFC3 KLC3 KRT31 KRT34 KRT36 KRT40 KRT6A KRT83 KRTAP10-3 KRTAP10-7 KRTAP10-8 LIMS1 LRP2BP LZTS2 MCRS1 MESD MGLL MID2 MIPOL1 MKRN3 MORN3 MSS51 MTUS2 MYOG NDUFAF3 NDUFB7 NDUFS8 NOTCH2NLA OIP5 PBX4 PDLIM7 PIH1D1 PLAGL2 PLEKHF2 PNMA1 POF1B PRDM14 PRDM6 RNF7 RUNDC3A SDHB SNAP91 SORBS3 SPAG5 SPATA6 SSX2IP TBC1D3B TBC1D3G TCF4 TFIP11 TGM7 TLE5 TP53BP2 TRAF1 TRAF2 TRIM10 TRIM23 TRIM27 TRIM32 TRIM54 TRIM69 USH1G USHBP1 VIM VPS28 VPS52 VTN WWOX YBEY YPEL3 YWHAB ZBTB42 ZC4H2 ZMAT5 ZNF20 ZNF552 ZNF655 ZNF688 ZNF774 ZRANB1 ZSCAN9
Entrez ID		784	2669
HPRD ID		11879	11553
Ensembl ID		ENSG00000167535	ENSG00000164949
Uniprot IDs		P54284	A0A024R9F5 P55040
PDB IDs			2CJW 2G3Y 2HT6
Enriched GO Terms of Interacting Partners?
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