Wiki-MPM
About
Search
Browse
People
Funding
Updates
Search
GEM and CTSL
Data Source:
BioGRID
(two hybrid)
GEM
CTSL
Description
GTP binding protein overexpressed in skeletal muscle
cathepsin L
Image
GO Annotations
Cellular Component
Nucleus
Plasma Membrane
Cytoplasmic Side Of Plasma Membrane
Midbody
Spindle Midzone
Mitotic Spindle
Extracellular Region
Extracellular Space
Nucleus
Lysosome
Multivesicular Body
Golgi Apparatus
Plasma Membrane
Apical Plasma Membrane
Endolysosome Lumen
Chromaffin Granule
Lysosomal Lumen
Intracellular Membrane-bounded Organelle
Collagen-containing Extracellular Matrix
Extracellular Exosome
Molecular Function
Magnesium Ion Binding
GTPase Activity
Calcium Channel Regulator Activity
Protein Binding
Calmodulin Binding
GTP Binding
GDP Binding
Fibronectin Binding
Cysteine-type Endopeptidase Activity
Protein Binding
Collagen Binding
Cysteine-type Peptidase Activity
Histone Binding
Proteoglycan Binding
Serpin Family Protein Binding
Biological Process
Mitotic Cell Cycle
Immune Response
Signal Transduction
Cell Surface Receptor Signaling Pathway
Chromosome Organization
Metaphase Plate Congression
Negative Regulation Of High Voltage-gated Calcium Channel Activity
Toll-like Receptor Signaling Pathway
Adaptive Immune Response
Proteolysis
Immune Response
Protein Autoprocessing
Fusion Of Virus Membrane With Host Plasma Membrane
Receptor-mediated Endocytosis Of Virus By Host Cell
Antigen Processing And Presentation
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II
Extracellular Matrix Disassembly
Collagen Catabolic Process
Zymogen Activation
Enkephalin Processing
Fusion Of Virus Membrane With Host Endosome Membrane
CD4-positive, Alpha-beta T Cell Lineage Commitment
Regulation Of Keratinocyte Differentiation
Viral Entry Into Host Cell
Antigen Processing And Presentation Of Peptide Antigen
Proteolysis Involved In Cellular Protein Catabolic Process
Elastin Catabolic Process
Macrophage Apoptotic Process
Cellular Response To Thyroid Hormone Stimulus
Pathways
Endosomal/Vacuolar pathway
Collagen degradation
Degradation of the extracellular matrix
Trafficking and processing of endosomal TLR
Assembly of collagen fibrils and other multimeric structures
MHC class II antigen presentation
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes
Attachment and Entry
Attachment and Entry
Attachment and Entry
Drugs
L-cysteic acid
Felbinac
Fostamatinib
Diseases
GWAS
Carotid plaque burden (
28282560
)
Coronary artery disease (
29212778
33020668
)
Pulse pressure (
30578418
)
Interacting Genes
128 interacting genes:
A2M
AHCYL1
ANKRD36B
APOH
ASB15
BEGAIN
BHLHB9
BLOC1S2
BLZF1
BMP1
C1orf131
CACNB3
CALM1
CARD9
CCDC102B
CCDC125
CCDC88B
CDR2
CEP70
CLDN15
CLEC4G
COG6
COG8
CTSL
CYSRT1
DBF4B
DEUP1
DISC1
ECSIT
EFHC2
EXOSC8
GADD45GIP1
GAS8
GMIP
GOLGA2
GOLGA6L9
GOPC
HOOK2
HSF2BP
IHO1
IKZF3
INCA1
INO80E
INSC
ISCA2
KATNBL1
KCTD9
KIFC3
KLC3
KRT31
KRT34
KRT36
KRT40
KRT6A
KRT83
KRTAP10-3
KRTAP10-7
KRTAP10-8
LIMS1
LRP2BP
LZTS2
MCRS1
MESD
MGLL
MID2
MIPOL1
MKRN3
MORN3
MSS51
MTUS2
MYOG
NDUFAF3
NDUFB7
NDUFS8
NOTCH2NLA
OIP5
PBX4
PDLIM7
PIH1D1
PLAGL2
PLEKHF2
PNMA1
POF1B
PRDM14
PRDM6
RNF7
RUNDC3A
SDHB
SNAP91
SORBS3
SPAG5
SPATA6
SSX2IP
TBC1D3B
TBC1D3G
TCF4
TFIP11
TGM7
TLE5
TP53BP2
TRAF1
TRAF2
TRIM10
TRIM23
TRIM27
TRIM32
TRIM54
TRIM69
USH1G
USHBP1
VIM
VPS28
VPS52
VTN
WWOX
YBEY
YPEL3
YWHAB
ZBTB42
ZC4H2
ZMAT5
ZNF20
ZNF552
ZNF655
ZNF688
ZNF774
ZRANB1
ZSCAN9
28 interacting genes:
ARSA
BAG6
BTN3A3
CD7
CD74
COL18A1
CST3
CST7
CSTA
CSTB
CTSC
CUX1
CXCL8
EED
GCG
GEM
IGFBP3
KNG1
MCPH1
PLAU
PPP1CC
RELB
RXRA
SERPINB13
SERPINB3
SGTA
SLPI
TG
Entrez ID
2669
1514
HPRD ID
11553
00293
Ensembl ID
ENSG00000164949
ENSG00000135047
Uniprot IDs
A0A024R9F5
P55040
A0A024R276
P07711
Q9HBQ7
PDB IDs
2CJW
2G3Y
2HT6
1CJL
1CS8
1ICF
1MHW
2NQD
2VHS
2XU1
2XU3
2XU4
2XU5
2YJ2
2YJ8
2YJ9
2YJB
2YJC
3BC3
3H89
3H8B
3H8C
3HHA
3HWN
3IV2
3K24
3KSE
3OF8
3OF9
4AXL
4AXM
5F02
5I4H
5MAE
5MAJ
5MQY
6EZP
6EZX
6F06
6JD0
6JD8
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?