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GEM and NDUFS8
Data Source:
BioGRID
(two hybrid)
GEM
NDUFS8
Description
GTP binding protein overexpressed in skeletal muscle
NADH:ubiquinone oxidoreductase core subunit S8
Image
GO Annotations
Cellular Component
Nucleus
Plasma Membrane
Cytoplasmic Side Of Plasma Membrane
Midbody
Spindle Midzone
Mitotic Spindle
Mitochondrion
Mitochondrial Respiratory Chain Complex I
Mitochondrial Matrix
Molecular Function
Magnesium Ion Binding
GTPase Activity
Calcium Channel Regulator Activity
Protein Binding
Calmodulin Binding
GTP Binding
GDP Binding
NADH Dehydrogenase Activity
Protein Binding
NADH Dehydrogenase (ubiquinone) Activity
Metal Ion Binding
4 Iron, 4 Sulfur Cluster Binding
Biological Process
Mitotic Cell Cycle
Immune Response
Signal Transduction
Cell Surface Receptor Signaling Pathway
Chromosome Organization
Metaphase Plate Congression
Negative Regulation Of High Voltage-gated Calcium Channel Activity
Mitochondrial Electron Transport, NADH To Ubiquinone
Response To Oxidative Stress
Aerobic Respiration
Mitochondrial Respiratory Chain Complex I Assembly
Pathways
Respiratory electron transport
Complex I biogenesis
Drugs
NADH
Diseases
Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
GWAS
Carotid plaque burden (
28282560
)
Coronary artery disease (
29212778
33020668
)
Pulse pressure (
30578418
)
Interacting Genes
128 interacting genes:
A2M
AHCYL1
ANKRD36B
APOH
ASB15
BEGAIN
BHLHB9
BLOC1S2
BLZF1
BMP1
C1orf131
CACNB3
CALM1
CARD9
CCDC102B
CCDC125
CCDC88B
CDR2
CEP70
CLDN15
CLEC4G
COG6
COG8
CTSL
CYSRT1
DBF4B
DEUP1
DISC1
ECSIT
EFHC2
EXOSC8
GADD45GIP1
GAS8
GMIP
GOLGA2
GOLGA6L9
GOPC
HOOK2
HSF2BP
IHO1
IKZF3
INCA1
INO80E
INSC
ISCA2
KATNBL1
KCTD9
KIFC3
KLC3
KRT31
KRT34
KRT36
KRT40
KRT6A
KRT83
KRTAP10-3
KRTAP10-7
KRTAP10-8
LIMS1
LRP2BP
LZTS2
MCRS1
MESD
MGLL
MID2
MIPOL1
MKRN3
MORN3
MSS51
MTUS2
MYOG
NDUFAF3
NDUFB7
NDUFS8
NOTCH2NLA
OIP5
PBX4
PDLIM7
PIH1D1
PLAGL2
PLEKHF2
PNMA1
POF1B
PRDM14
PRDM6
RNF7
RUNDC3A
SDHB
SNAP91
SORBS3
SPAG5
SPATA6
SSX2IP
TBC1D3B
TBC1D3G
TCF4
TFIP11
TGM7
TLE5
TP53BP2
TRAF1
TRAF2
TRIM10
TRIM23
TRIM27
TRIM32
TRIM54
TRIM69
USH1G
USHBP1
VIM
VPS28
VPS52
VTN
WWOX
YBEY
YPEL3
YWHAB
ZBTB42
ZC4H2
ZMAT5
ZNF20
ZNF552
ZNF655
ZNF688
ZNF774
ZRANB1
ZSCAN9
2 interacting genes:
GEM
UBC
Entrez ID
2669
4728
HPRD ID
11553
03683
Ensembl ID
ENSG00000164949
ENSG00000110717
Uniprot IDs
A0A024R9F5
P55040
O00217
PDB IDs
2CJW
2G3Y
2HT6
5XTB
5XTD
5XTH
5XTI
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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