MAP3K12 and MBIP

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		MAP3K12	MBIP
Description		mitogen-activated protein kinase kinase kinase 12	MAP3K12 binding inhibitory protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane Growth Cone	Nucleoplasm Ada2/Gcn5/Ada3 Transcription Activator Complex Nucleolus Cytosol
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity JUN Kinase Kinase Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Protein Homodimerization Activity	Protein Kinase Inhibitor Activity Protein Binding Identical Protein Binding
	Biological Process	Protein Phosphorylation JNK Cascade Activation Of JNKK Activity Activation Of JUN Kinase Activity Histone Phosphorylation Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Intracellular Signal Transduction Positive Regulation Of Transcription, DNA-templated Protein Autophosphorylation Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Motor Neuron Apoptotic Process	Osmosensory Signaling MAPK Cascade Histone H3 Acetylation
Pathways			HATs acetylate histones
Drugs		Fostamatinib
Diseases
GWAS		Body mass index ( 28892062) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Hypertension ( 31513605) Thyroid cancer ( 22267200) Thyroid hormone levels ( 23408906) Thyroid stimulating hormone levels ( 32769997 25743335)
Interacting Genes		16 interacting genes: EGFR FRA10AC1 FTL MAP2K4 MAP2K7 MAP3K11 MAPK6 MAPK8IP1 MAPK8IP2 MBIP MTDH RGS1 RPL18A SH3RF1 TGM2 TSC22D1	44 interacting genes: BFSP2 CALM1 CCDC85B CCNC CEP63 COPS4 DGCR6 DGCR6L DIP2A DRC7 EPB41L3 EXOC8 FXR2 ING5 KAT14 KLC3 LIMS1 LMNB1 LMO2 LMO3 MAP3K12 MAPK6 MCM7 MIS18A MOAP1 MYD88 NDEL1 NINL PIK3R3 PLEKHF2 POLR1C PPFIA1 RAP1GDS1 RAPGEF1 SMARCB1 STX11 TGIF2LY TRIM55 TRIM63 TXLNA TXLNB VPS28 VTA1 WDR5
Entrez ID		7786	51562
HPRD ID		02709	14368
Ensembl ID		ENSG00000139625	ENSG00000151332
Uniprot IDs		A0A024RAY5 Q12852	B2RCV0 Q9NS73
PDB IDs		5CEN 5CEO 5CEP 5CEQ 5VO1 5VO2
Enriched GO Terms of Interacting Partners?
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