MAP3K12 and MAP2K4

Data Source:
HPRD (in vitro)

		MAP3K12	MAP2K4
Description		mitogen-activated protein kinase kinase kinase 12	mitogen-activated protein kinase kinase 4
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane Growth Cone	Nucleus Cytosol Axon Dendrite Cytoplasm Perikaryon
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity JUN Kinase Kinase Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Protein Homodimerization Activity	Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding JUN Kinase Kinase Activity Mitogen-activated Protein Kinase Kinase Kinase Binding
	Biological Process	Protein Phosphorylation JNK Cascade Activation Of JNKK Activity Activation Of JUN Kinase Activity Histone Phosphorylation Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Intracellular Signal Transduction Positive Regulation Of Transcription, DNA-templated Protein Autophosphorylation Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Motor Neuron Apoptotic Process	Activation Of MAPK Activity Apoptotic Process Signal Transduction JNK Cascade Activation Of JUN Kinase Activity Response To Wounding Peptidyl-tyrosine Phosphorylation Positive Regulation Of Smooth Muscle Cell Apoptotic Process Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of DNA Replication Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process Cell Growth Involved In Cardiac Muscle Cell Development Cellular Response To Mechanical Stimulus Cellular Response To Sorbitol Negative Regulation Of Motor Neuron Apoptotic Process
Pathways			Oxidative Stress Induced Senescence Oxidative Stress Induced Senescence FCERI mediated MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Uptake and function of anthrax toxins MAP3K8 (TPL2)-dependent MAPK1/3 activation
Drugs		Fostamatinib
Diseases
GWAS		Body mass index ( 28892062) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Asthma ( 32296059) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 31152163) Response to amphetamines ( 22952603)
Interacting Genes		16 interacting genes: EGFR FRA10AC1 FTL MAP2K4 MAP2K7 MAP3K11 MAPK6 MAPK8IP1 MAPK8IP2 MBIP MTDH RGS1 RPL18A SH3RF1 TGM2 TSC22D1	43 interacting genes: AKT1 ALDOB APP ARRB1 ARRB2 CFLAR CYLC2 DUSP22 EFNA4 FBP2 FLNA FLNC GEMIN5 ITCH JUN LRRK2 MAP2K6 MAP3K1 MAP3K10 MAP3K11 MAP3K12 MAP3K14 MAP3K2 MAP3K20 MAP3K3 MAP3K4 MAP3K5 MAP3K7 MAP3K8 MAP4K2 MAPK1 MAPK10 MAPK12 MAPK14 MAPK8 MAPK8IP3 MAPK9 NBR1 RBBP8 SPAG9 STX17 TRIB1 UBC
Entrez ID		7786	6416
HPRD ID		02709	03213
Ensembl ID		ENSG00000139625	ENSG00000065559
Uniprot IDs		A0A024RAY5 Q12852	P45985
PDB IDs		5CEN 5CEO 5CEP 5CEQ 5VO1 5VO2	3ALN 3ALO 3VUT
Enriched GO Terms of Interacting Partners?
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