RGS12 and GRM5

Data Source:
HPRD (in vitro)

		RGS12	GRM5
Description		regulator of G protein signaling 12	glutamate metabotropic receptor 5
Image
GO Annotations	Cellular Component	Condensed Nuclear Chromosome Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Plasma Membrane Nuclear Matrix Dendrite Synapse	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Neuron Projection Schaffer Collateral - CA1 Synapse Postsynaptic Density Membrane
	Molecular Function	GTPase Activity GTPase Activator Activity Protein Binding GTPase Regulator Activity	Adenylate Cyclase Inhibiting G Protein-coupled Glutamate Receptor Activity G Protein-coupled Receptor Activity Protein Binding Glutamate Receptor Activity Protein Tyrosine Kinase Activator Activity Identical Protein Binding G Protein-coupled Receptor Activity Involved In Regulation Of Postsynaptic Membrane Potential Neurotransmitter Receptor Activity Involved In Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration Protein Tyrosine Kinase Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Signal Transduction Positive Regulation Of GTPase Activity	Regulation Of Protein Phosphorylation Regulation Of Translation Regulation Of Translational Elongation G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Glutamate Receptor Signaling Pathway G Protein-coupled Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Learning Or Memory Learning Locomotory Behavior Calcium-mediated Signaling Using Intracellular Calcium Source Regulation Of Long-term Neuronal Synaptic Plasticity Synapse Organization Cognition Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Postsynaptic Membrane Potential Positive Regulation Of Protein Tyrosine Kinase Activity Modulation Of Age-related Behavioral Decline Postsynaptic Modulation Of Chemical Synaptic Transmission Trans-synaptic Signaling By Endocannabinoid, Modulating Synaptic Transmission Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration Regulation Of Intracellular Calcium Activated Chloride Channel Activity Cellular Response To Amyloid-beta
Pathways		G alpha (i) signalling events G alpha (i) signalling events	G alpha (q) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors) Neurexins and neuroligins Neurexins and neuroligins
Drugs			Acamprosate ADX10059 Rufinamide Dipraglurant
Diseases
GWAS		Adult body size ( 32376654) Blood protein levels ( 28240269) Coronary artery disease ( 29212778) Creatinine levels ( 29403010) Estimated glomerular filtration rate ( 31015462 30604766) Glomerular filtration rate ( 29403010) Hepatocyte growth factor levels ( 25998175) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (HMG CoA reductase inhibitors) ( 31015401) Platelet count ( 29403010) Serum albumin level ( 29403010) Total cholesterol levels ( 29403010) Tuberculosis ( 29036319) Worry too long after an embarrassing experience ( 29500382)	Attention deficit hyperactivity disorder ( 22012869) Blond vs. brown/black hair color ( 30531825) Coronary artery calcified atherosclerotic plaque score in type 2 diabetes ( 29221444) Fish- and plant-related diet ( 32066663) General factor of neuroticism ( 30867560) Hair color ( 30664655) Hypertension ( 31879980) Neurociticism ( 29500382) Nonsyndromic cleft lip ( 31609978) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Retinal detachment ( 31816047) Retinal detachment or retinal break ( 31816047) Rheumatoid arthritis (ACPA-negative) ( 24532677) Skin pigmentation ( 31315583 30664655) Skin pigmentation (conditioned on rs1426654 and rs35397) ( 31315583) Skin, hair and eye pigmentation (multivariate analysis) ( 30664655) Tanning ( 19340012)
Interacting Genes		17 interacting genes: ARAF CACNA1B CXCR2 EEF1A1 GNAI1 GNAI2 GNAI3 GRM2 GRM5 HRAS MAP2K2 MTNR1A NPY2R PLCB1 PLCB3 PM20D2 YWHAG	19 interacting genes: ACTN1 CALM1 CALM2 CALM3 EFNB2 FLNA GPRASP1 HOMER1 HOMER3 PRKCA PRKCB PRKCD PRKCE PRKCG PRKCQ PRKCZ RGS12 SIAH1 TAMALIN
Entrez ID		6002	2915
HPRD ID		03943	04980
Ensembl ID		ENSG00000159788	ENSG00000168959
Uniprot IDs		O14924	A8K5P7 P41594
PDB IDs		2EBZ 2KV8	3LMK 4OO9 5CGC 5CGD 6N4X 6N4Y 6N50 6N51 6N52
Enriched GO Terms of Interacting Partners?
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