ZAP70 and CARD11

Data Source:
HPRD (in vivo)

		ZAP70	CARD11
Description		zeta chain of T cell receptor associated protein kinase 70	caspase recruitment domain family member 11
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GO Annotations	Cellular Component	Immunological Synapse Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane T Cell Receptor Complex Membrane Raft	Immunological Synapse Cytoplasm Cytosol Plasma Membrane CBM Complex Membrane Raft Extracellular Exosome
	Molecular Function	Phosphotyrosine Residue Binding Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signaling Receptor Binding Protein Binding ATP Binding	Guanylate Kinase Activity Protein Binding CARD Domain Binding
	Biological Process	Adaptive Immune Response Protein Phosphorylation Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Peptidyl-tyrosine Phosphorylation Cell Differentiation T Cell Differentiation Intracellular Signal Transduction T Cell Activation B Cell Activation Beta Selection Positive Thymic T Cell Selection Negative Thymic T Cell Selection Innate Immune Response Positive Regulation Of T Cell Differentiation Positive Regulation Of Alpha-beta T Cell Differentiation Positive Regulation Of Alpha-beta T Cell Proliferation Positive Regulation Of Calcium-mediated Signaling T Cell Receptor Signaling Pathway T Cell Aggregation T Cell Migration	Stimulatory C-type Lectin Receptor Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling B Cell Differentiation Positive Regulation Of B Cell Proliferation T Cell Costimulation Positive Regulation Of Interleukin-2 Production Fc-epsilon Receptor Signaling Pathway TORC1 Signaling B Cell Proliferation Positive Regulation Of T Cell Proliferation Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Thymic T Cell Selection Regulation Of B Cell Differentiation Regulation Of T Cell Differentiation GMP Metabolic Process GDP Metabolic Process Homeostasis Of Number Of Cells T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity
Pathways		Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules	Activation of NF-kappaB in B cells Activation of NF-kappaB in B cells Downstream TCR signaling FCERI mediated NF-kB activation FCERI mediated NF-kB activation CLEC7A (Dectin-1) signaling
Drugs		Staurosporine Fostamatinib
Diseases		Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency
GWAS		Bipolar disorder ( 31043756) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cardiac Troponin-T levels ( 31014085) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Diastolic blood pressure ( 30224653) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Atopic dermatitis ( 23042114) Cadmium levels ( 26025379) Daytime sleep phenotypes ( 27126917) Dupuytren's disease ( 28886342) Intracranial aneurysm ( 29531279) Multiple sclerosis ( 31604244 24076602) Response to fenofibrate (total cholesterol levels) ( 27002377) Ulcerative colitis ( 23128233) White matter integrity ( 23218918)
Interacting Genes		66 interacting genes: ABL1 ACP1 ANAPC11 APP ASB3 CARD11 CBL CBLB CBLC CD247 CD3E CD5 CD79B CRK CSK DAPK1 DBNL DEF6 DUSP3 EGFR ERBB2 ERBB3 ERBB4 FCGR3A FCRL3 FYN GAB2 GRB2 IFNAR1 KIT LAT LAX1 LCK LCP2 LRRK2 MET MUC1 NDUFB8 NFAM1 NR0B2 PAG1 PLCG1 PRLR PTK2B PTPN22 PTPN3 PTPN6 PTPRC RASA1 RNF41 SH2B3 SH3BP2 SHB SHC1 SIT1 SLA SLA2 SLAMF6 SOS1 TUBA1A TUBA4A TUBB TYROBP USP2 VAV1 WIPF1	15 interacting genes: BCL10 IKBKG MAP3K7 MAP4K1 PDPK1 PPP2CA PPP2R1A PRKCB PRKCQ RNF181 SH2D3C SRPK2 TAB1 WDR1 ZAP70
Entrez ID		7535	84433
HPRD ID		01495	06234
Ensembl ID		ENSG00000115085	ENSG00000198286
Uniprot IDs		P43403	A0A024R854 Q8TES3 Q9BXL7
PDB IDs		1FBV 1M61 1U59 2CBL 2OQ1 2OZO 2Y1N 3ZNI 4A4B 4A4C 4K2R 4XZ0 4XZ1 5O76	4JUP 4LWD
Enriched GO Terms of Interacting Partners?
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