ZAP70 and TUBA4A

Data Source:
HPRD (in vivo)

		ZAP70	TUBA4A
Description		zeta chain of T cell receptor associated protein kinase 70	tubulin alpha 4a
Image			No pdb structure
GO Annotations	Cellular Component	Immunological Synapse Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane T Cell Receptor Complex Membrane Raft	Extracellular Region Cytoplasm Cytosol Cytoskeleton Microtubule Microtubule Cytoskeleton Extracellular Exosome
	Molecular Function	Phosphotyrosine Residue Binding Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signaling Receptor Binding Protein Binding ATP Binding	GTPase Activity Structural Constituent Of Cytoskeleton Protein Binding GTP Binding Protein Kinase Binding
	Biological Process	Adaptive Immune Response Protein Phosphorylation Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Peptidyl-tyrosine Phosphorylation Cell Differentiation T Cell Differentiation Intracellular Signal Transduction T Cell Activation B Cell Activation Beta Selection Positive Thymic T Cell Selection Negative Thymic T Cell Selection Innate Immune Response Positive Regulation Of T Cell Differentiation Positive Regulation Of Alpha-beta T Cell Differentiation Positive Regulation Of Alpha-beta T Cell Proliferation Positive Regulation Of Calcium-mediated Signaling T Cell Receptor Signaling Pathway T Cell Aggregation T Cell Migration	G2/M Transition Of Mitotic Cell Cycle Microtubule Cytoskeleton Organization Mitotic Cell Cycle Platelet Degranulation Regulation Of G2/M Transition Of Mitotic Cell Cycle Ciliary Basal Body-plasma Membrane Docking
Pathways		Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules	Platelet degranulation Translocation of SLC2A4 (GLUT4) to the plasma membrane Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Gap junction assembly MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Post-chaperonin tubulin folding pathway Recycling pathway of L1 Recycling pathway of L1 Hedgehog 'off' state Cilium Assembly Anchoring of the basal body to the plasma membrane Intraflagellar transport RHO GTPases activate IQGAPs RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase The role of GTSE1 in G2/M progression after G2 checkpoint AURKA Activation by TPX2 Carboxyterminal post-translational modifications of tubulin Carboxyterminal post-translational modifications of tubulin HCMV Early Events Assembly and cell surface presentation of NMDA receptors Activation of AMPK downstream of NMDARs Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation Sealing of the nuclear envelope (NE) by ESCRT-III Kinesins
Drugs		Staurosporine Fostamatinib	Vincristine Podofilox Epothilone D Patupilone CYT997 Cabazitaxel Phenethyl Isothiocyanate
Diseases		Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency
GWAS		Bipolar disorder ( 31043756) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cardiac Troponin-T levels ( 31014085) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Diastolic blood pressure ( 30224653) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Platelet distribution width ( 32888494 27863252)
Interacting Genes		66 interacting genes: ABL1 ACP1 ANAPC11 APP ASB3 CARD11 CBL CBLB CBLC CD247 CD3E CD5 CD79B CRK CSK DAPK1 DBNL DEF6 DUSP3 EGFR ERBB2 ERBB3 ERBB4 FCGR3A FCRL3 FYN GAB2 GRB2 IFNAR1 KIT LAT LAX1 LCK LCP2 LRRK2 MET MUC1 NDUFB8 NFAM1 NR0B2 PAG1 PLCG1 PRLR PTK2B PTPN22 PTPN3 PTPN6 PTPRC RASA1 RNF41 SH2B3 SH3BP2 SHB SHC1 SIT1 SLA SLA2 SLAMF6 SOS1 TUBA1A TUBA4A TUBB TYROBP USP2 VAV1 WIPF1	51 interacting genes: APC ARHGAP1 B4GALT1 BCAR1 BRCA1 C4orf17 CALB2 EGFR ENO2 EPB41 FYN GNAI2 GPHN GRM7 HDAC6 HSPH1 LGALS2 LTA MAGED1 MAP1A MAP1LC3A MAPT MARK4 MYC NCALD PFDN4 PLK1 PRKN RAB8B RAC1 RACGAP1 RBM23 RTN4 S100A8 SIAH1 SIMC1 SIRT2 STARD13 SUMO2 SYK TAOK2 TBCB TBCE TCP1 TCP11L2 TM4SF1 UCHL5 VAV1 VDAC1 YWHAG ZAP70
Entrez ID		7535	7277
HPRD ID		01495	01851
Ensembl ID		ENSG00000115085	ENSG00000127824
Uniprot IDs		P43403	P68366
PDB IDs		1FBV 1M61 1U59 2CBL 2OQ1 2OZO 2Y1N 3ZNI 4A4B 4A4C 4K2R 4XZ0 4XZ1 5O76
Enriched GO Terms of Interacting Partners?
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