ZAP70 and PTPN22

Data Source:
HPRD (in vivo)

		ZAP70	PTPN22
Description		zeta chain of T cell receptor associated protein kinase 70	protein tyrosine phosphatase non-receptor type 22
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GO Annotations	Cellular Component	Immunological Synapse Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane T Cell Receptor Complex Membrane Raft	Nucleus Cytoplasm Cytosol Cytoplasmic Side Of Plasma Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Phosphotyrosine Residue Binding Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signaling Receptor Binding Protein Binding ATP Binding	Protein Tyrosine Phosphatase Activity Non-membrane Spanning Protein Tyrosine Phosphatase Activity Protein Binding Phosphatase Activity SH3 Domain Binding Kinase Binding Ubiquitin Protein Ligase Binding
	Biological Process	Adaptive Immune Response Protein Phosphorylation Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Peptidyl-tyrosine Phosphorylation Cell Differentiation T Cell Differentiation Intracellular Signal Transduction T Cell Activation B Cell Activation Beta Selection Positive Thymic T Cell Selection Negative Thymic T Cell Selection Innate Immune Response Positive Regulation Of T Cell Differentiation Positive Regulation Of Alpha-beta T Cell Differentiation Positive Regulation Of Alpha-beta T Cell Proliferation Positive Regulation Of Calcium-mediated Signaling T Cell Receptor Signaling Pathway T Cell Aggregation T Cell Migration	Positive Regulation Of Defense Response To Virus By Host Protein Dephosphorylation Autophagy Negative Regulation Of Autophagy Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression T Cell Differentiation Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Type I Interferon Production Response To Lipopolysaccharide Negative Regulation Of Interleukin-6 Production Negative Regulation Of Interleukin-8 Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interferon-gamma Production Regulation Of Natural Killer Cell Proliferation Positive Regulation Of Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Toll-like Receptor 7 Signaling Pathway Positive Regulation Of Toll-like Receptor 9 Signaling Pathway Peptidyl-tyrosine Dephosphorylation Phosphoanandamide Dephosphorylation Negative Regulation Of JUN Kinase Activity Regulation Of Innate Immune Response T Cell Receptor Signaling Pathway Regulation Of B Cell Receptor Signaling Pathway Negative Regulation Of T Cell Receptor Signaling Pathway Negative Regulation Of T Cell Activation Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Cellular Response To Muramyl Dipeptide Positive Regulation Of Granzyme B Production Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Protein K63-linked Ubiquitination Negative Regulation Of P38MAPK Cascade Positive Regulation Of CD8-positive, Alpha-beta T Cell Proliferation
Pathways		Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules	Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse
Drugs		Staurosporine Fostamatinib
Diseases		Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency	Type I diabetes mellitus
GWAS		Bipolar disorder ( 31043756) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cardiac Troponin-T levels ( 31014085) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Diastolic blood pressure ( 30224653) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Alopecia areata ( 25608926) Antineutrophil cytoplasmic antibody-associated vasculitis ( 28029757) Arthritis (juvenile idiopathic) ( 33106285) Autoimmune thyroid disease ( 32581359) Autoimmune thyroid diseases (Graves disease or Hashimoto's thyroiditis) ( 22922229) Autoimmune traits (pleiotropy) ( 30572963) Breast cancer ( 23535729) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 18587394 28067908 21102463 23128233) Giant cell arteritis ( 25817017) Granulocyte count ( 27863252) Graves' disease ( 22922229) Gut microbiota (bacterial taxa) ( 27694959) Hashimoto thyroiditis ( 22922229) Hodgkin's lymphoma ( 30194254) Hypothyroidism ( 27182965 22493691) Idiopathic inflammatory myopathy ( 26362759) IgM levels ( 28628107) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Late-onset myasthenia gravis ( 26562150) Latent autoimmune diabetes vs. type 2 diabetes ( 30254083) Lymphocyte counts ( 32888494 27863252) Medication use (drugs used in diabetes) ( 31015401) Medication use (thyroid preparations) ( 31015401) Monocyte count ( 32888494) Myasthenia gravis ( 23055271) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252) Obesity-related traits ( 23251661) Pediatric autoimmune diseases ( 26301688) Polymyositis ( 26362759) Rheumatoid arthritis ( 24449572 17804836 30891314 30423114 18794853 17554300 21156761 30572963 23143596 24390342 20453842 19503088) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Systemic lupus erythematosus ( 27399966 26502338 28714469 19838195) Systemic lupus erythematosus or rheumatoid arthritis ( 27193031) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655) Thyroid peroxidase antibody levels ( 24586183) Type 1 diabetes ( 21829393 17632545 25751624 19430480 17554260 17554300 30572963 18978792) Type 1 diabetes and autoimmune thyroid diseases ( 25936594) Type 1 diabetes autoantibodies in high risk HLA genotype individuals (time to event) ( 29310926) Vitiligo ( 20410501 27723757) White blood cell count ( 32888494 27863252)
Interacting Genes		66 interacting genes: ABL1 ACP1 ANAPC11 APP ASB3 CARD11 CBL CBLB CBLC CD247 CD3E CD5 CD79B CRK CSK DAPK1 DBNL DEF6 DUSP3 EGFR ERBB2 ERBB3 ERBB4 FCGR3A FCRL3 FYN GAB2 GRB2 IFNAR1 KIT LAT LAX1 LCK LCP2 LRRK2 MET MUC1 NDUFB8 NFAM1 NR0B2 PAG1 PLCG1 PRLR PTK2B PTPN22 PTPN3 PTPN6 PTPRC RASA1 RNF41 SH2B3 SH3BP2 SHB SHC1 SIT1 SLA SLA2 SLAMF6 SOS1 TUBA1A TUBA4A TUBB TYROBP USP2 VAV1 WIPF1	12 interacting genes: CBL CD247 CD3E CLK1 CSK EGFR GRB2 LCK PRKCD SRPK2 VAV1 ZAP70
Entrez ID		7535	26191
HPRD ID		01495	06100
Ensembl ID		ENSG00000115085	ENSG00000134242
Uniprot IDs		P43403	B4DZW8 G3K0T4 Q9Y2R2
PDB IDs		1FBV 1M61 1U59 2CBL 2OQ1 2OZO 2Y1N 3ZNI 4A4B 4A4C 4K2R 4XZ0 4XZ1 5O76	2P6X 2QCJ 2QCT 3BRH 3H2X 3OLR 3OMH 4J51
Enriched GO Terms of Interacting Partners?
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