YWHAZ and LNX1

Data Source:
BioGRID (two hybrid)

		YWHAZ	LNX1
Description		tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta	ligand of numb-protein X 1
Image
GO Annotations	Cellular Component	Extracellular Space Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Focal Adhesion Vesicle Melanosome Extracellular Exosome Blood Microparticle Glutamatergic Synapse	Cytoplasm
	Molecular Function	RNA Binding Protein Binding Transcription Factor Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Ion Channel Binding Cadherin Binding	Ubiquitin-protein Transferase Activity Protein Binding PDZ Domain Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Protein Phosphorylation Signal Transduction Cytokine-mediated Signaling Pathway Platelet Activation Negative Regulation Of Apoptotic Process Regulation Of MRNA Stability Establishment Of Golgi Localization Membrane Organization Regulation Of ERK1 And ERK2 Cascade Regulation Of Synapse Maturation Golgi Reassembly Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination
Pathways		Activation of BAD and translocation to mitochondria Translocation of SLC2A4 (GLUT4) to the plasma membrane Deactivation of the beta-catenin transactivating complex Rap1 signalling GP1b-IX-V activation signalling KSRP (KHSRP) binds and destabilizes mRNA Interleukin-3, Interleukin-5 and GM-CSF signaling RHO GTPases activate PKNs TP53 Regulates Metabolic Genes Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex NOTCH4 Activation and Transmission of Signal to the Nucleus Negative regulation of NOTCH4 signaling Regulation of localization of FOXO transcription factors	Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Phenethyl Isothiocyanate
Diseases
GWAS		Adventurousness ( 30643258) Attention deficit hyperactivity disorder and conduct disorder ( 18951430) Body mass index ( 25673413) Chronotype ( 30696823) Cognitive decline rate in late mild cognitive impairment ( 26252872) General risk tolerance (MTAG) ( 30643258) High light scatter reticulocyte count ( 32888494) Interleukin-10 levels ( 22205395)	Beard thickness ( 26926045) Cervical artery dissection ( 25420145) DNA methylation (variation) ( 23725790) Heel bone mineral density ( 30598549) Height ( 28552196) Peginterferon alfa-2a treatment response in chronic hepatitis B infection ( 30972912) Uterine fibroids ( 30194396 31649266)
Interacting Genes		210 interacting genes: AANAT ABL1 ADAM22 ADRA2A ADRA2B ADRA2C AKAP13 AKT1 APP ARHGEF2 ATP5F1A ATXN1 BAD BCAR1 BCR BRAF BSPRY CBL CCDC125 CDC25A CDC25B CDC25C CDC5L CDK11B CDK16 CDK17 CDKN1B CENPJ CEP126 CEP131 CFL1 CGNL1 CLIC4 COP1 CRTC2 CSF2RB CSNK1A1 CSNK1D DFFA DISC1 EFNB3 EGFR EIF3A ENO1 EP300 EPB41L1 EPB41L2 EPB41L3 ERBB2 ERBB3 EXO1 FAM13B FHOD1 FOXO1 FOXO3 FOXO4 GABARAPL2 GABBR1 GCH1 GP1BA GP1BB GP5 GPSM3 GSK3B H3C1 HDAC4 HDAC6 HDAC9 HIVEP2 HMGN1 HSPA1A HSPA1B HSPB1 IGF1R IL9R ING1 INPP5A IRAG2 IRS1 IRS2 ITPRID2 KANK1 KCNK15 KCNK3 KCNK9 KIAA0232 KIAA0930 KIF1C KIF5B KLC2 KLC4 KLF11 KRT18 KSR1 LARP1 LATS2 LCP2 LIMK1 LNX1 LYST MADD MAP2K5 MAP3K2 MAP3K20 MAP3K3 MAP3K4 MAP3K5 MAPK8 MAPKAPK2 MAPT MARK2 MARK3 MARK4 MDM4 MEF2C MINK1 MLF1 MPHOSPH9 MSL2 MST1R MTNR1A MYH9 NEDD4L NFATC2 NFATC4 NR4A1 PAK1 PAK4 PARD3 PARD6A PARD6B PDC PFKFB2 PIAS1 PIK3R1 PPP1CC PPP1R14A PPP1R3D PRDX2 PRKACA PRKAR1A PRKCA PRKCD PRKCI PRKCZ PRKD1 PRLR PRMT5 PSMA5 PTPN13 PTPRO RAF1 RALGPS2 RAP1GAP2 RASAL3 REM1 RGS3 RIN1 RPRD1A RRAD SAMSN1 SH3GL1 SIK1 SIK3 SIMC1 SLC8A2 SNAPIN SNX24 SORBS2 SQSTM1 SSX2IP STK25 STK38 SYN2 SYNPO SYNPO2 TAB2 TBC1D7 TBXA2R TERT TH TJP2 TLK2 TNFAIP3 TNS1 TP53 TPD52L1 TPH1 TRA2B TRIM21 TSC1 TSC2 TUBB UBC UBE3A UCHL5 UCP2 UCP3 USP8 VCP VIM WEE1 WNK1 WNK2 WWTR1 XRCC6 YAP1 YWHAE YWHAG ZNF839	474 interacting genes: ABCA1 ABCB1 ABI2 ABR ACAT2 ACTN1 ACTN3 ACTN4 ACY3 ADAMTSL4 ADRA1D AGTRAP AIDA AIMP2 AKIRIN2 ALDOC ALKBH3 AMMECR1L ANKS1A AP1M1 APIP APOL4 APP ARF3 ARFIP2 ARHGAP6 ARHGEF16 ARVCF ATPAF2 ATRIP AURKB AURKC AXIN2 BCR BEND7 BICD2 BIRC2 BLVRA BLZF1 BORCS6 BPIFA1 BTBD1 C10orf88 C1QTNF1 CA8 CABP5 CADPS CALCOCO2 CAMK2N2 CARD9 CASP6 CATSPERD CBX1 CBY1 CBY2 CCBE1 CCDC102B CCDC33 CCDC85B CCDC88B CCDC91 CCNDBP1 CDA CDC42EP4 CDIPT CDKN2D CEP70 CEP72 CEP76 CEP85 CGN CIB3 CIRBP CITED1 CLDN1 CLDN17 CLDN2 CLK1 CLK2 CLK3 CMTM5 COIL CPNE2 CPSF7 CRACR2B CRX CTBP1 CTNND2 CTSO CUTC CXADR CYSLTR2 CYSRT1 DAB1 DAPK1 DCTD DCTPP1 DCUN1D5 DDIT3 DDX17 DENND1B DEPTOR DERL1 DEUP1 DHPS DMC1 DNPEP DOCK9 DPF2 DRAP1 DRG1 DTX2 DUSP29 DVL3 DYDC1 DYNLT1 EBF4 EDC3 EEF2KMT EFEMP2 EFHC2 EGLN3 EHMT2 EIF1AD EIF4A3 EIF4H ENOX1 ENOX2 EPHB3 EPM2AIP1 EVI5L EXOC8 EXOSC1 EXOSC4 EXOSC8 FAM118A FAM124A FAM90A1 FAM9B FASN FBP1 FBXL12 FHL3 FOXP2 FSD2 FXR1 GAS2L2 GDI1 GIPR GJD2 GJD4 GLRX3 GMCL1 GMNN GOLPH3L GPKOW GPR142 GRAP2 GRB2 GRIN1 GRIPAP1 GUCD1 HDX HEXIM2 HIP1 HMBOX1 HMG20A HNRNPF HNRNPH1 HOMER3 HOMEZ HOOK2 HOXA1 HSBP1 HSF2BP HTR2B HUNK IGSF5 IHO1 IKZF3 IL16 IL3RA ILF3 INKA2 INO80E INSC IP6K3 ISCU JAK3 JOSD1 KALRN KATNAL2 KCNA4 KCTD1 KCTD13 KCTD17 KCTD6 KCTD7 KCTD9 KHDRBS2 KHDRBS3 KIAA1328 KIF24 KIFC3 KLHL12 KPRP KRT15 KRT16 KRTAP1-1 KRTAP10-8 KRTAP12-3 KRTAP13-3 KRTAP2-3 KRTAP2-4 KRTAP4-12 KRTAP4-2 KRTAP5-9 KRTAP6-3 KRTAP9-2 KRTAP9-3 KRTAP9-8 KXD1 LCLAT1 LCP2 LDB2 LDOC1 LEPROTL1 LGALS14 LGR6 LHX2 LNX2 LONRF1 LRRC3B LRRC73 LSM2 LUZP4 LZTS1 MAD1L1 MAGEA11 MAGEB18 MAPK9 MAPRE2 MEMO1 MEOX2 METTL21A MID2 MLX MRFAP1L1 MRPS24 MRPS6 MSANTD4 MSC MTMR9 MTUS2 MUSTN1 MVB12B MYEF2 NAB2 NADK NAGK NBPF19 NCK2 NDC80 NDOR1 NDUFAB1 NECAB1 NECAB2 NEK6 NKD2 NME1 NME7 NOTCH2NLA NRCAM NUDT14 NUMB NUP37 NUP62 NXT2 ODAD1 ORMDL1 ORMDL3 OSBP2 OSBPL3 OSGIN1 PAFAH1B3 PAICS PAK5 PBK PBLD PCBD1 PDE3B PDZRN3 PDZRN4 PFDN5 PKDREJ PKM PKP4 PLEKHA2 PNMA1 PNMA3 PNMA5 PNMT POMGNT1 POU6F2 PPIA PPID PPIH PPP1R13B PQBP1 PRDM14 PRKAR1B PRKRA PRMT5 PRPH PRR13 PRTFDC1 PSMC1 PSME2 PSME3 PSMF1 PTGIR PTPN11 PTS PURB QARS1 RAB33A RABAC1 RABIF RAD51D RAD54B RALY RASL11B RBAK RBCK1 RBM20 RBMX RBMY1A1 RBMY1F RBMY1J REEP6 RFPL3 RGS20 RIOX2 ROBO3 ROPN1 RPIA RPS6KA1 RUFY4 RUNDC3A RUVBL2 S100A3 S100B SAPCD1 SAT1 SCLT1 SCML1 SCML2 SCNM1 SDK1 SEPTIN1 SGF29 SH2D2A SHFL SHTN1 SLC6A15 SLC6A5 SNCB SNRNP25 SNRPA SNRPF SOCS6 SP4 SPG21 SPHKAP SRSF1 SRSF3 SSNA1 SSTR3 STAC2 STRN STX5 SUV39H1 SUV39H2 SYCE1L SYTL2 TACO1 TAX1BP1 TBC1D1 TBCEL TCF12 TCL1A TDO2 TEKT4 TGM7 THAP1 THAP7 THG1L TIFA TMEM14C TMEM239 TNFAIP1 TNFAIP3 TNFRSF18 TPM4 TRAF1 TRAF2 TRAF3 TRAF4 TRAF5 TRAF6 TRIM10 TRIM14 TRIM21 TRIM23 TRIM27 TRIM3 TRIM39 TRIM42 TRIM50 TRIM54 TRIM60 TRIM68 TRIM8 TRIP13 TRIP6 TRMT12 TSC2 TSC22D4 TSG101 TSN TSPYL2 TSSK3 TYRO3 UBASH3A UBE2D2 UBE2D4 UBE2N UBE2V2 UBP1 ULK2 UPP2 USP54 VASN VCP VMAC VPS37B VPS52 VRK2 WAC WDR25 WNT8A WWP1 YWHAZ ZADH2 ZBED1 ZBTB2 ZBTB24 ZBTB26 ZBTB43 ZBTB8A ZCCHC10 ZFP64 ZGPAT ZNF148 ZNF213 ZNF263 ZNF346 ZNF426 ZNF446 ZNF552 ZNF581 ZNF593 ZNF655 ZRANB1
Entrez ID		7534	84708
HPRD ID		03183	17287
Ensembl ID		ENSG00000164924	ENSG00000072201
Uniprot IDs		D0PNI1 P63104	Q8TBB1
PDB IDs		1IB1 1QJA 1QJB 2C1J 2C1N 2O02 2WH0 3CU8 3NKX 3RDH 4BG6 4FJ3 4HKC 4IHL 4N7G 4N7Y 4N84 4WRQ 4ZDR 5D2D 5D3F 5EWZ 5EXA 5J31 5JM4 5M35 5M36 5M37 5NAS 5ULO 5WXN 5XY9 6EF5 6EJL 6EWW 6F08 6F09 6FN9 6FNA 6FNB 6FNC 6Q0K 6RLZ 6U2H 6XAG	3B76 5H7R 5H7S
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?