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YWHAZ and ADRA2B
Data Source:
HPRD
(in vitro)
YWHAZ
ADRA2B
Description
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
adrenoceptor alpha 2B
Image
GO Annotations
Cellular Component
Extracellular Space
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Cytosol
Focal Adhesion
Vesicle
Melanosome
Extracellular Exosome
Blood Microparticle
Glutamatergic Synapse
Cytosol
Plasma Membrane
Integral Component Of Plasma Membrane
Cell Surface
Intracellular Membrane-bounded Organelle
Molecular Function
RNA Binding
Protein Binding
Transcription Factor Binding
Protein Kinase Binding
Ubiquitin Protein Ligase Binding
Identical Protein Binding
Ion Channel Binding
Cadherin Binding
G Protein-coupled Receptor Activity
Alpha2-adrenergic Receptor Activity
Protein Binding
Epinephrine Binding
Biological Process
Protein Phosphorylation
Signal Transduction
Cytokine-mediated Signaling Pathway
Platelet Activation
Negative Regulation Of Apoptotic Process
Regulation Of MRNA Stability
Establishment Of Golgi Localization
Membrane Organization
Regulation Of ERK1 And ERK2 Cascade
Regulation Of Synapse Maturation
Golgi Reassembly
Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Activation Of MAPK Activity
Regulation Of Vascular Associated Smooth Muscle Contraction
G Protein-coupled Receptor Signaling Pathway
Cell-cell Signaling
Female Pregnancy
Negative Regulation Of Norepinephrine Secretion
Platelet Activation
Activation Of Protein Kinase B Activity
Negative Regulation Of Epinephrine Secretion
Receptor Transactivation
Positive Regulation Of MAPK Cascade
Positive Regulation Of Neuron Differentiation
Positive Regulation Of Blood Pressure
Positive Regulation Of Uterine Smooth Muscle Contraction
Adrenergic Receptor Signaling Pathway
Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway
Pathways
Activation of BAD and translocation to mitochondria
Translocation of SLC2A4 (GLUT4) to the plasma membrane
Deactivation of the beta-catenin transactivating complex
Rap1 signalling
GP1b-IX-V activation signalling
KSRP (KHSRP) binds and destabilizes mRNA
Interleukin-3, Interleukin-5 and GM-CSF signaling
RHO GTPases activate PKNs
TP53 Regulates Metabolic Genes
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
NOTCH4 Activation and Transmission of Signal to the Nucleus
Negative regulation of NOTCH4 signaling
Regulation of localization of FOXO transcription factors
Adrenoceptors
Adrenaline signalling through Alpha-2 adrenergic receptor
G alpha (i) signalling events
G alpha (z) signalling events
Drugs
Phenethyl Isothiocyanate
Amphetamine
Tramadol
Bethanidine
Ziprasidone
Cabergoline
Ropinirole
Etomidate
Clozapine
Norepinephrine
Phenylpropanolamine
Loxapine
Prochlorperazine
Prazosin
Chlorpromazine
Brimonidine
Haloperidol
Nortriptyline
Amoxapine
Clonidine
Lisuride
Guanabenz
Epinephrine
Tizanidine
Apomorphine
Paroxetine
Trimipramine
Risperidone
Tolazoline
Fenoldopam
Phenoxybenzamine
Maprotiline
Oxymetazoline
Apraclonidine
Guanfacine
Ergoloid mesylate
Promethazine
Carvedilol
Desipramine
Escitalopram
Pergolide
Bromocriptine
Quetiapine
Aripiprazole
Paliperidone
Ephedra sinica root
Mephentermine
Yohimbine
Methotrimeprazine
Dextroamphetamine
Metamfetamine
Celiprolol
Dronedarone
Rotigotine
OPC-28326
Epicept NP-1
Mianserin
Pizotifen
Asenapine
Ocaperidone
Droxidopa
Esmirtazapine
Xylometazoline
Levonordefrin
Dosulepin
Etoperidone
Lorpiprazole
Cirazoline
Moxisylyte
Aranidipine
Setiptiline
Racepinephrine
Dihydroergocornine
DL-Methylephedrine
Xylazine
Indigotindisulfonic acid
Tiapride
Dihydroergocristine
Aripiprazole lauroxil
Diseases
GWAS
Adventurousness (
30643258
)
Attention deficit hyperactivity disorder and conduct disorder (
18951430
)
Body mass index (
25673413
)
Chronotype (
30696823
)
Cognitive decline rate in late mild cognitive impairment (
26252872
)
General risk tolerance (MTAG) (
30643258
)
High light scatter reticulocyte count (
32888494
)
Interleukin-10 levels (
22205395
)
Monocyte percentage of white cells (
32888494
)
Interacting Genes
210 interacting genes:
AANAT
ABL1
ADAM22
ADRA2A
ADRA2B
ADRA2C
AKAP13
AKT1
APP
ARHGEF2
ATP5F1A
ATXN1
BAD
BCAR1
BCR
BRAF
BSPRY
CBL
CCDC125
CDC25A
CDC25B
CDC25C
CDC5L
CDK11B
CDK16
CDK17
CDKN1B
CENPJ
CEP126
CEP131
CFL1
CGNL1
CLIC4
COP1
CRTC2
CSF2RB
CSNK1A1
CSNK1D
DFFA
DISC1
EFNB3
EGFR
EIF3A
ENO1
EP300
EPB41L1
EPB41L2
EPB41L3
ERBB2
ERBB3
EXO1
FAM13B
FHOD1
FOXO1
FOXO3
FOXO4
GABARAPL2
GABBR1
GCH1
GP1BA
GP1BB
GP5
GPSM3
GSK3B
H3C1
HDAC4
HDAC6
HDAC9
HIVEP2
HMGN1
HSPA1A
HSPA1B
HSPB1
IGF1R
IL9R
ING1
INPP5A
IRAG2
IRS1
IRS2
ITPRID2
KANK1
KCNK15
KCNK3
KCNK9
KIAA0232
KIAA0930
KIF1C
KIF5B
KLC2
KLC4
KLF11
KRT18
KSR1
LARP1
LATS2
LCP2
LIMK1
LNX1
LYST
MADD
MAP2K5
MAP3K2
MAP3K20
MAP3K3
MAP3K4
MAP3K5
MAPK8
MAPKAPK2
MAPT
MARK2
MARK3
MARK4
MDM4
MEF2C
MINK1
MLF1
MPHOSPH9
MSL2
MST1R
MTNR1A
MYH9
NEDD4L
NFATC2
NFATC4
NR4A1
PAK1
PAK4
PARD3
PARD6A
PARD6B
PDC
PFKFB2
PIAS1
PIK3R1
PPP1CC
PPP1R14A
PPP1R3D
PRDX2
PRKACA
PRKAR1A
PRKCA
PRKCD
PRKCI
PRKCZ
PRKD1
PRLR
PRMT5
PSMA5
PTPN13
PTPRO
RAF1
RALGPS2
RAP1GAP2
RASAL3
REM1
RGS3
RIN1
RPRD1A
RRAD
SAMSN1
SH3GL1
SIK1
SIK3
SIMC1
SLC8A2
SNAPIN
SNX24
SORBS2
SQSTM1
SSX2IP
STK25
STK38
SYN2
SYNPO
SYNPO2
TAB2
TBC1D7
TBXA2R
TERT
TH
TJP2
TLK2
TNFAIP3
TNS1
TP53
TPD52L1
TPH1
TRA2B
TRIM21
TSC1
TSC2
TUBB
UBC
UBE3A
UCHL5
UCP2
UCP3
USP8
VCP
VIM
WEE1
WNK1
WNK2
WWTR1
XRCC6
YAP1
YWHAE
YWHAG
ZNF839
8 interacting genes:
EIF2B1
GGA1
GGA2
GGA3
GNAI2
PPP1R9B
UCHL1
YWHAZ
Entrez ID
7534
151
HPRD ID
03183
00086
Ensembl ID
ENSG00000164924
ENSG00000274286
Uniprot IDs
D0PNI1
P63104
P18089
PDB IDs
1IB1
1QJA
1QJB
2C1J
2C1N
2O02
2WH0
3CU8
3NKX
3RDH
4BG6
4FJ3
4HKC
4IHL
4N7G
4N7Y
4N84
4WRQ
4ZDR
5D2D
5D3F
5EWZ
5EXA
5J31
5JM4
5M35
5M36
5M37
5NAS
5ULO
5WXN
5XY9
6EF5
6EJL
6EWW
6F08
6F09
6FN9
6FNA
6FNB
6FNC
6Q0K
6RLZ
6U2H
6XAG
2CVA
6K41
6K42
Enriched GO Terms of Interacting Partners
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