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YWHAZ and YWHAG
Data Source:
BioGRID
(affinity chromatography technology, biochemical, fluorescent resonance energy transfer)
YWHAZ
YWHAG
Description
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma
Image
GO Annotations
Cellular Component
Extracellular Space
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Cytosol
Focal Adhesion
Vesicle
Melanosome
Extracellular Exosome
Blood Microparticle
Glutamatergic Synapse
Mitochondrion
Cytosol
Focal Adhesion
Membrane
Extracellular Exosome
Presynapse
Molecular Function
RNA Binding
Protein Binding
Transcription Factor Binding
Protein Kinase Binding
Ubiquitin Protein Ligase Binding
Identical Protein Binding
Ion Channel Binding
Cadherin Binding
RNA Binding
Protein Kinase C Binding
Insulin-like Growth Factor Receptor Binding
Protein Binding
Protein Kinase C Inhibitor Activity
Protein Domain Specific Binding
Receptor Tyrosine Kinase Binding
Identical Protein Binding
Biological Process
Protein Phosphorylation
Signal Transduction
Cytokine-mediated Signaling Pathway
Platelet Activation
Negative Regulation Of Apoptotic Process
Regulation Of MRNA Stability
Establishment Of Golgi Localization
Membrane Organization
Regulation Of ERK1 And ERK2 Cascade
Regulation Of Synapse Maturation
Golgi Reassembly
Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
G2/M Transition Of Mitotic Cell Cycle
Negative Regulation Of Protein Kinase Activity
Protein Targeting
Regulation Of Signal Transduction
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Cellular Response To Insulin Stimulus
Regulation Of Neuron Differentiation
Regulation Of Synaptic Plasticity
Membrane Organization
Negative Regulation Of Protein Serine/threonine Kinase Activity
Ciliary Basal Body-plasma Membrane Docking
Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Pathways
Activation of BAD and translocation to mitochondria
Translocation of SLC2A4 (GLUT4) to the plasma membrane
Deactivation of the beta-catenin transactivating complex
Rap1 signalling
GP1b-IX-V activation signalling
KSRP (KHSRP) binds and destabilizes mRNA
Interleukin-3, Interleukin-5 and GM-CSF signaling
RHO GTPases activate PKNs
TP53 Regulates Metabolic Genes
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
NOTCH4 Activation and Transmission of Signal to the Nucleus
Negative regulation of NOTCH4 signaling
Regulation of localization of FOXO transcription factors
Activation of BAD and translocation to mitochondria
Translocation of SLC2A4 (GLUT4) to the plasma membrane
Regulation of PLK1 Activity at G2/M Transition
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Anchoring of the basal body to the plasma membrane
RHO GTPases activate PKNs
TP53 Regulates Metabolic Genes
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
AURKA Activation by TPX2
Regulation of localization of FOXO transcription factors
Drugs
Phenethyl Isothiocyanate
Diseases
GWAS
Adventurousness (
30643258
)
Attention deficit hyperactivity disorder and conduct disorder (
18951430
)
Body mass index (
25673413
)
Chronotype (
30696823
)
Cognitive decline rate in late mild cognitive impairment (
26252872
)
General risk tolerance (MTAG) (
30643258
)
High light scatter reticulocyte count (
32888494
)
Interleukin-10 levels (
22205395
)
Multiple sclerosis (
21654844
)
Schizophrenia (
30285260
)
Interacting Genes
210 interacting genes:
AANAT
ABL1
ADAM22
ADRA2A
ADRA2B
ADRA2C
AKAP13
AKT1
APP
ARHGEF2
ATP5F1A
ATXN1
BAD
BCAR1
BCR
BRAF
BSPRY
CBL
CCDC125
CDC25A
CDC25B
CDC25C
CDC5L
CDK11B
CDK16
CDK17
CDKN1B
CENPJ
CEP126
CEP131
CFL1
CGNL1
CLIC4
COP1
CRTC2
CSF2RB
CSNK1A1
CSNK1D
DFFA
DISC1
EFNB3
EGFR
EIF3A
ENO1
EP300
EPB41L1
EPB41L2
EPB41L3
ERBB2
ERBB3
EXO1
FAM13B
FHOD1
FOXO1
FOXO3
FOXO4
GABARAPL2
GABBR1
GCH1
GP1BA
GP1BB
GP5
GPSM3
GSK3B
H3C1
HDAC4
HDAC6
HDAC9
HIVEP2
HMGN1
HSPA1A
HSPA1B
HSPB1
IGF1R
IL9R
ING1
INPP5A
IRAG2
IRS1
IRS2
ITPRID2
KANK1
KCNK15
KCNK3
KCNK9
KIAA0232
KIAA0930
KIF1C
KIF5B
KLC2
KLC4
KLF11
KRT18
KSR1
LARP1
LATS2
LCP2
LIMK1
LNX1
LYST
MADD
MAP2K5
MAP3K2
MAP3K20
MAP3K3
MAP3K4
MAP3K5
MAPK8
MAPKAPK2
MAPT
MARK2
MARK3
MARK4
MDM4
MEF2C
MINK1
MLF1
MPHOSPH9
MSL2
MST1R
MTNR1A
MYH9
NEDD4L
NFATC2
NFATC4
NR4A1
PAK1
PAK4
PARD3
PARD6A
PARD6B
PDC
PFKFB2
PIAS1
PIK3R1
PPP1CC
PPP1R14A
PPP1R3D
PRDX2
PRKACA
PRKAR1A
PRKCA
PRKCD
PRKCI
PRKCZ
PRKD1
PRLR
PRMT5
PSMA5
PTPN13
PTPRO
RAF1
RALGPS2
RAP1GAP2
RASAL3
REM1
RGS3
RIN1
RPRD1A
RRAD
SAMSN1
SH3GL1
SIK1
SIK3
SIMC1
SLC8A2
SNAPIN
SNX24
SORBS2
SQSTM1
SSX2IP
STK25
STK38
SYN2
SYNPO
SYNPO2
TAB2
TBC1D7
TBXA2R
TERT
TH
TJP2
TLK2
TNFAIP3
TNS1
TP53
TPD52L1
TPH1
TRA2B
TRIM21
TSC1
TSC2
TUBB
UBC
UBE3A
UCHL5
UCP2
UCP3
USP8
VCP
VIM
WEE1
WNK1
WNK2
WWTR1
XRCC6
YAP1
YWHAE
YWHAG
ZNF839
290 interacting genes:
ABL1
ABLIM1
ACIN1
AFDN
AKAP13
AKT1S1
ALB
ANKHD1-EIF4EBP3
ANKS1A
APP
ARAF
ARHGEF2
ARHGEF6
ARHGEF7
ATP5F1A
ATP5F1B
ATP6V0B
BAD
BAIAP2
BAIAP2L1
BCLAF1
BCR
BRAF
C1QBP
CAD
CAMKK1
CASP3
CBL
CCNY
CCS
CCT2
CDC5L
CDK11B
CDK16
CDK17
CDKN1B
CENPJ
CEP170
CEP250
CEP95
CFAP20
CFL1
CGN
CGNL1
CHAF1A
CHEK1
CKAP2
CLASP1
CLINT1
CLK1
CLK2
CLK3
CLTC
COPS5
CPSF3
CRTC1
CRTC2
CRTC3
CSE1L
CTNND1
CTPS1
CYFIP2
DCAF7
DCP1A
DDX17
DDX27
DDX39B
DENND4A
DFFA
DHX15
DISC1
DOCK7
DYNC1H1
DYRK1A
EDC3
EEF1A1
EEF1G
EML3
EPB41L2
EPB41L3
EPN2
ERC1
EWSR1
EXO1
FAM13B
FARP2
FGD6
FLNA
FOXO1
FOXO3
GBF1
GIT1
GIT2
GSK3A
GTPBP4
H3C1
HDAC4
HDAC7
HECTD1
HGF
HIVEP2
HNRNPAB
HNRNPH1
HNRNPM
HOXC10
HSPA1A
HSPA8
HSPA9
HSPB6
HSPD1
IGF1R
IL7R
ING1
INPP5E
IRS1
IRS2
IRS4
ITPRID2
JAKMIP1
KANK1
KAT5
KCNK15
KCNK3
KCNK9
KIAA0408
KIAA0930
KIF1B
KIF1C
KIF23
KIF5B
KIF5C
KLC2
KLC3
KRT18
LARP1
LATS2
LBR
LIMA1
LMO7
LRCH3
LSR
LTB4R
LUC7L2
LUC7L3
MAGOHB
MAP3K2
MAP3K20
MAP3K3
MAPKAP1
MARK3
MCM5
MDM4
MFAP1
MICALL1
MIEF1
MPHOSPH9
MPRIP
MSL2
MYCBP2
MYH10
N4BP3
NCKAP1
NCKIPSD
NDE1
NDEL1
NEDD4L
NEFL
NHSL2
NOLC1
NUFIP2
NUMBL
OSBPL3
P4HB
PABPC1
PAK1
PAK4
PARD3
PARD3B
PFKFB2
PGAM5
PHLDB2
PI4KB
PIK3C3
PIK3R1
PKP2
PLA2G12A
PLEKHA5
PNN
POT1
PPFIA1
PPFIBP1
PPIG
PPP1R12A
PPP6R3
PRKCA
PRKCB
PRKCD
PRKCG
PRKCQ
PRKDC
PRLR
PRMT1
PRMT5
PRPF38B
PRPF40A
PRPF4B
PTPN14
PTPN3
PUF60
RAB11FIP2
RAB11FIP5
RABEP1
RACGAP1
RAF1
RAI14
RALGPS2
RAPGEF6
RASAL2
RASSF8
RGS12
RIPOR2
RMDN3
RNPS1
RPS2
RRM1
SAMD4A
SAMD4B
SF3B3
SFN
SH3BP4
SH3BP5L
SHKBP1
SHPRH
SHROOM2
SIMC1
SLC25A3
SMARCD1
SNRNP200
SON
SPOP
SPTBN1
SRC
SRGAP2
SRPK1
SRRM1
SRRM2
SRSF10
SRSF3
STK11
SVIL
SYNPO
SYNPO2
TAB1
TAF15
TBC1D1
TBC1D4
TERF1
TFE3
THRAP3
TIAM1
TINF2
TJP2
TMEM102
TNFAIP3
TP53
TP53BP2
TRA2A
TRA2B
TSC1
TSC2
TUBA4A
TUBB
TUBB4A
UBC
UBE3A
UCP2
UCP3
USP37
USP8
WEE1
WNK1
WWTR1
YAP1
YWHAB
YWHAE
YWHAH
YWHAQ
YWHAZ
ZBTB21
ZFP36
Entrez ID
7534
7532
HPRD ID
03183
05639
Ensembl ID
ENSG00000164924
ENSG00000170027
Uniprot IDs
D0PNI1
P63104
P61981
PDB IDs
1IB1
1QJA
1QJB
2C1J
2C1N
2O02
2WH0
3CU8
3NKX
3RDH
4BG6
4FJ3
4HKC
4IHL
4N7G
4N7Y
4N84
4WRQ
4ZDR
5D2D
5D3F
5EWZ
5EXA
5J31
5JM4
5M35
5M36
5M37
5NAS
5ULO
5WXN
5XY9
6EF5
6EJL
6EWW
6F08
6F09
6FN9
6FNA
6FNB
6FNC
6Q0K
6RLZ
6U2H
6XAG
2B05
3UZD
4E2E
4J6S
4O46
5D3E
6A5S
6BYJ
6BYL
6BZD
6FEL
6GKF
6GKG
6S9K
6SAD
Enriched GO Terms of Interacting Partners
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