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YWHAG and HGF
Data Source:
BioGRID
(fluorescent resonance energy transfer)
YWHAG
HGF
Description
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma
hepatocyte growth factor
Image
GO Annotations
Cellular Component
Mitochondrion
Cytosol
Focal Adhesion
Membrane
Extracellular Exosome
Presynapse
Extracellular Region
Extracellular Space
Membrane
Platelet Alpha Granule Lumen
Molecular Function
RNA Binding
Protein Kinase C Binding
Insulin-like Growth Factor Receptor Binding
Protein Binding
Protein Kinase C Inhibitor Activity
Protein Domain Specific Binding
Receptor Tyrosine Kinase Binding
Identical Protein Binding
Serine-type Endopeptidase Activity
Protein Binding
Growth Factor Activity
Chemoattractant Activity
Identical Protein Binding
Protein-containing Complex Binding
Biological Process
G2/M Transition Of Mitotic Cell Cycle
Negative Regulation Of Protein Kinase Activity
Protein Targeting
Regulation Of Signal Transduction
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Cellular Response To Insulin Stimulus
Regulation Of Neuron Differentiation
Regulation Of Synaptic Plasticity
Membrane Organization
Negative Regulation Of Protein Serine/threonine Kinase Activity
Ciliary Basal Body-plasma Membrane Docking
Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
MAPK Cascade
Activation Of MAPK Activity
Mitotic Cell Cycle
Cell Morphogenesis
Epithelial To Mesenchymal Transition
Liver Development
Positive Regulation Of Protein Phosphorylation
Platelet Degranulation
Proteolysis
Negative Regulation Of Autophagy
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Cytokine-mediated Signaling Pathway
Hyaluronan Metabolic Process
Positive Regulation Of Cell Migration
Animal Organ Regeneration
Positive Regulation Of Myelination
Negative Regulation Of Interleukin-6 Production
Positive Regulation Of Interleukin-10 Production
Negative Regulation Of Peptidyl-serine Phosphorylation
Cellular Response To Hepatocyte Growth Factor Stimulus
Negative Regulation Of Apoptotic Process
Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Positive Regulation Of Osteoblast Differentiation
Positive Regulation Of Angiogenesis
Positive Regulation Of Transcription By RNA Polymerase II
Hepatocyte Growth Factor Receptor Signaling Pathway
Epithelial Cell Proliferation
Negative Regulation Of Inflammatory Response
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Positive Chemotaxis
Myoblast Proliferation
Positive Regulation Of Protein Kinase B Signaling
Cell Chemotaxis
Regulation Of Branching Involved In Salivary Gland Morphogenesis By Mesenchymal-epithelial Signaling
Positive Regulation Of Neuron Projection Regeneration
Negative Regulation Of Release Of Cytochrome C From Mitochondria
Regulation Of P38MAPK Cascade
Negative Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Regulation Of Tau-protein Kinase Activity
Positive Regulation Of DNA Biosynthetic Process
Pathways
Activation of BAD and translocation to mitochondria
Translocation of SLC2A4 (GLUT4) to the plasma membrane
Regulation of PLK1 Activity at G2/M Transition
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Anchoring of the basal body to the plasma membrane
RHO GTPases activate PKNs
TP53 Regulates Metabolic Genes
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
AURKA Activation by TPX2
Regulation of localization of FOXO transcription factors
Platelet degranulation
PIP3 activates AKT signaling
Interleukin-7 signaling
Constitutive Signaling by Aberrant PI3K in Cancer
RAF/MAP kinase cascade
Interleukin-4 and Interleukin-13 signaling
MET Receptor Activation
Negative regulation of MET activity
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
MET activates RAS signaling
MET activates PI3K/AKT signaling
MET activates PTPN11
MET activates PTK2 signaling
MET interacts with TNS proteins
MET activates RAP1 and RAC1
MET receptor recycling
MET activates STAT3
Drugs
Heparin
O2-Sulfo-Glucuronic Acid
N,O6-Disulfo-Glucosamine
ABT-510
Foretinib
Diseases
GWAS
Multiple sclerosis (
21654844
)
Schizophrenia (
30285260
)
Blood protein levels (
30072576
29875488
)
Endothelial growth factor levels (
25552591
)
Gestational age at birth (maternal effect) (
28598419
)
Gout (
22179738
)
Gout (normal type) (
32238385
)
Hepatocyte growth factor levels (
27989323
25998175
)
Intraocular pressure (
29785010
29235454
)
Rosacea symptom severity (
29771307
)
Spontaneous preterm birth (maternal effect) (
28598419
)
Transverse temporal cortex volume (
31530798
)
Tuberculosis (
29036319
)
Interacting Genes
290 interacting genes:
ABL1
ABLIM1
ACIN1
AFDN
AKAP13
AKT1S1
ALB
ANKHD1-EIF4EBP3
ANKS1A
APP
ARAF
ARHGEF2
ARHGEF6
ARHGEF7
ATP5F1A
ATP5F1B
ATP6V0B
BAD
BAIAP2
BAIAP2L1
BCLAF1
BCR
BRAF
C1QBP
CAD
CAMKK1
CASP3
CBL
CCNY
CCS
CCT2
CDC5L
CDK11B
CDK16
CDK17
CDKN1B
CENPJ
CEP170
CEP250
CEP95
CFAP20
CFL1
CGN
CGNL1
CHAF1A
CHEK1
CKAP2
CLASP1
CLINT1
CLK1
CLK2
CLK3
CLTC
COPS5
CPSF3
CRTC1
CRTC2
CRTC3
CSE1L
CTNND1
CTPS1
CYFIP2
DCAF7
DCP1A
DDX17
DDX27
DDX39B
DENND4A
DFFA
DHX15
DISC1
DOCK7
DYNC1H1
DYRK1A
EDC3
EEF1A1
EEF1G
EML3
EPB41L2
EPB41L3
EPN2
ERC1
EWSR1
EXO1
FAM13B
FARP2
FGD6
FLNA
FOXO1
FOXO3
GBF1
GIT1
GIT2
GSK3A
GTPBP4
H3C1
HDAC4
HDAC7
HECTD1
HGF
HIVEP2
HNRNPAB
HNRNPH1
HNRNPM
HOXC10
HSPA1A
HSPA8
HSPA9
HSPB6
HSPD1
IGF1R
IL7R
ING1
INPP5E
IRS1
IRS2
IRS4
ITPRID2
JAKMIP1
KANK1
KAT5
KCNK15
KCNK3
KCNK9
KIAA0408
KIAA0930
KIF1B
KIF1C
KIF23
KIF5B
KIF5C
KLC2
KLC3
KRT18
LARP1
LATS2
LBR
LIMA1
LMO7
LRCH3
LSR
LTB4R
LUC7L2
LUC7L3
MAGOHB
MAP3K2
MAP3K20
MAP3K3
MAPKAP1
MARK3
MCM5
MDM4
MFAP1
MICALL1
MIEF1
MPHOSPH9
MPRIP
MSL2
MYCBP2
MYH10
N4BP3
NCKAP1
NCKIPSD
NDE1
NDEL1
NEDD4L
NEFL
NHSL2
NOLC1
NUFIP2
NUMBL
OSBPL3
P4HB
PABPC1
PAK1
PAK4
PARD3
PARD3B
PFKFB2
PGAM5
PHLDB2
PI4KB
PIK3C3
PIK3R1
PKP2
PLA2G12A
PLEKHA5
PNN
POT1
PPFIA1
PPFIBP1
PPIG
PPP1R12A
PPP6R3
PRKCA
PRKCB
PRKCD
PRKCG
PRKCQ
PRKDC
PRLR
PRMT1
PRMT5
PRPF38B
PRPF40A
PRPF4B
PTPN14
PTPN3
PUF60
RAB11FIP2
RAB11FIP5
RABEP1
RACGAP1
RAF1
RAI14
RALGPS2
RAPGEF6
RASAL2
RASSF8
RGS12
RIPOR2
RMDN3
RNPS1
RPS2
RRM1
SAMD4A
SAMD4B
SF3B3
SFN
SH3BP4
SH3BP5L
SHKBP1
SHPRH
SHROOM2
SIMC1
SLC25A3
SMARCD1
SNRNP200
SON
SPOP
SPTBN1
SRC
SRGAP2
SRPK1
SRRM1
SRRM2
SRSF10
SRSF3
STK11
SVIL
SYNPO
SYNPO2
TAB1
TAF15
TBC1D1
TBC1D4
TERF1
TFE3
THRAP3
TIAM1
TINF2
TJP2
TMEM102
TNFAIP3
TP53
TP53BP2
TRA2A
TRA2B
TSC1
TSC2
TUBA4A
TUBB
TUBB4A
UBC
UBE3A
UCP2
UCP3
USP37
USP8
WEE1
WNK1
WWTR1
YAP1
YWHAB
YWHAE
YWHAH
YWHAQ
YWHAZ
ZBTB21
ZFP36
37 interacting genes:
ADAMTSL4
ARNT
BRCA1
CCND2
CDK4
CDK6
CDKN2A
CDKN2B
CLEC3B
EPHA2
ERBB2
F11
FGFR4
FN1
GLIS2
HGFAC
HPN
KLKB1
LATS2
LCN2
MAP2K5
MAP2K6
MDM4
MEOX2
MET
MYC
NF2
PDGFRA
PLAU
RAF1
SDC1
SDC2
ST14
STK11
TEAD2
VTN
YWHAG
Entrez ID
7532
3082
HPRD ID
05639
00799
Ensembl ID
ENSG00000170027
ENSG00000019991
Uniprot IDs
P61981
P14210
PDB IDs
2B05
3UZD
4E2E
4J6S
4O46
5D3E
6A5S
6BYJ
6BYL
6BZD
6FEL
6GKF
6GKG
6S9K
6SAD
1BHT
1GMN
1GMO
1GP9
1NK1
1SHY
1SI5
2HGF
2QJ2
3HMS
3HMT
3HN4
3MKP
3SP8
4D3C
4K3J
4O3T
4O3U
5COE
5CP9
5CS1
5CS3
5CS5
5CS9
5CSQ
5CT1
5CT2
5CT3
Enriched GO Terms of Interacting Partners
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