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YWHAE and GRAP2
Data Source:
HPRD
(two hybrid)
YWHAE
GRAP2
Description
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
GRB2 related adaptor protein 2
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Mitochondrion
Cytosol
Kinesin Complex
Plasma Membrane
Focal Adhesion
Membrane
Melanosome
Extracellular Exosome
Central Region Of Growth Cone
Glutamatergic Synapse
Nucleus
Nucleoplasm
Cytoplasm
Endosome
Cytosol
Plasma Membrane
Molecular Function
RNA Binding
Calcium Channel Regulator Activity
Protein Binding
Potassium Channel Regulator Activity
Enzyme Binding
MHC Class II Protein Complex Binding
Ubiquitin Protein Ligase Binding
Identical Protein Binding
Histone Deacetylase Binding
Ion Channel Binding
Cadherin Binding
Protein Heterodimerization Activity
Phosphoserine Residue Binding
Phosphoprotein Binding
Scaffold Protein Binding
Protein Binding
Biological Process
G2/M Transition Of Mitotic Cell Cycle
MAPK Cascade
Regulation Of Heart Rate By Hormone
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Viral Process
Substantia Nigra Development
Protein Localization To Nucleus
Cellular Response To Heat
Hippo Signaling
Intracellular Signal Transduction
Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Positive Regulation Of Protein Export From Nucleus
Regulation Of Cytosolic Calcium Ion Concentration
Regulation Of Membrane Repolarization
Membrane Organization
Membrane Repolarization During Cardiac Muscle Cell Action Potential
Regulation Of Heart Rate By Cardiac Conduction
Ciliary Basal Body-plasma Membrane Docking
Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels
Regulation Of Cellular Response To Heat
Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Regulation Of Potassium Ion Transmembrane Transporter Activity
Negative Regulation Of Calcium Ion Transmembrane Transporter Activity
Negative Regulation Of Peptidyl-serine Dephosphorylation
Negative Regulation Of Calcium Ion Export Across Plasma Membrane
Ras Protein Signal Transduction
Cell-cell Signaling
T Cell Costimulation
Fc-epsilon Receptor Signaling Pathway
T Cell Receptor Signaling Pathway
Pathways
Activation of BAD and translocation to mitochondria
Translocation of SLC2A4 (GLUT4) to the plasma membrane
Signaling by Hippo
NADE modulates death signalling
Regulation of PLK1 Activity at G2/M Transition
Regulation of HSF1-mediated heat shock response
HSF1 activation
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Anchoring of the basal body to the plasma membrane
RHO GTPases activate PKNs
TP53 Regulates Metabolic Genes
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
AURKA Activation by TPX2
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
RAB GEFs exchange GTP for GDP on RABs
Signaling by SCF-KIT
Generation of second messenger molecules
DAP12 signaling
FCERI mediated MAPK activation
FCERI mediated Ca+2 mobilization
FCERI mediated Ca+2 mobilization
CD28 co-stimulation
FLT3 Signaling
Drugs
Fusicoccin
Phenethyl Isothiocyanate
Diseases
Lissencephaly (LIS); Miller-Dieker syndrome (MDLS)
GWAS
Atrial fibrillation (
30061737
)
High light scatter reticulocyte percentage of red cells (
32888494
)
Mean platelet volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Nicotine dependence symptom count (
25555482
)
Reaction time (
29844566
)
Schizophrenia (
28991256
30285260
)
Body mass index (
26426971
)
Systemic lupus erythematosus (
28714469
)
Interacting Genes
147 interacting genes:
-
ABL1
ACD
AKAP13
AKAP9
ANKHD1-EIF4EBP3
ANKZF1
ARHGEF2
ARHGEF28
ATP6V0B
ATXN1
BAD
BCR
BEX3
CALM1
CAP2
CASK
CASP3
CCDC125
CCR9
CDC25A
CDC25B
CDK11B
CDK14
CDK16
CDKN1B
CEP131
CEP95
CGNL1
CHAF1A
CHST11
CYSLTR2
DDX54
DISC1
DYRK1A
ENKD1
EXO1
FAM13B
FAM53C
FGF12
FHL1
FTH1
GAPDH
GPRIN2
GRAP2
GSTA1
GSTM3
GTF2B
HDAC4
HDAC5
HIVEP2
HNRNPC
HSF1
HSPB1
IGF1R
IL7R
ING1
IRAG2
IRS1
IRS2
ITPRID2
KANK1
KCNH2
KCNK15
KCNK3
KCNK9
KIAA0232
KIF1C
KLC4
KRT18
LCP2
MAGEB4
MAP3K1
MAP3K10
MAP3K2
MAP3K3
MAP3K5
MAPK7
MCM10
MDM4
METAP2
MSL2
MST1R
MT-CO2
MYH10
NAF1
NCOR2
NDEL1
NIN
PAPOLA
PARD3B
PCM1
PIMREG
PNLIP
POT1
PRC1
PRDX6
PRKCG
RAB11FIP2
RAF1
RAP1GAP2
RASAL3
RASGRF1
RBIS
RBM14
REM1
RGS3
RIN1
RPA2
RPGR
RXFP3
SAMSN1
SH3BP4
SLC8A1
SLC8A2
SLC8A3
SMAGP
SNAPIN
SNCA
SNF8
SORBS2
SRC
SYN2
TAF7
TAZ
TBC1D3F
TBP
TCEANC
TFDP2
TGFB1
TLK1
TNFAIP3
TOP2A
TSC1
TSC2
UBE3A
USP43
VIM
WNK1
WWTR1
YWHAB
YWHAG
YWHAH
YWHAQ
YWHAZ
ZC3HC1
ZNF839
79 interacting genes:
AR
BAG4
BEND5
BLNK
CBL
CBLB
CBY2
CCHCR1
CCNDBP1
CD28
COG6
CSF1R
DNM2
DVL2
EGFR
ERBB2
ERBB3
ERBB4
ETV5
FASLG
GAB1
GAB2
GAB3
GAREM1
GATA1
GFAP
GOLGA2
GRB2
HNRNPK
IHO1
IKZF3
KHDRBS1
KHDRBS2
KIT
KPRP
KRT13
KRTAP1-3
KRTAP4-11
KRTAP4-12
LAT
LATS2
LAX1
LCP2
LNX1
LNX2
MAGED1
MAP4K1
MKRN3
MOS
MTUS2
PBLD
PNMA1
PRKAA2
PRPH2
PRR35
RACK1
RAVER1
RBPMS
RIN3
RINT1
SH2D4A
SHB
SHC1
SOS2
SPRY2
SSX2IP
STAMBP
TFIP11
TLE5
TRAF1
TSNAXIP1
USP8
WWP2
YWHAE
ZBTB7B
ZNF250
ZNF319
ZNF526
ZSCAN21
Entrez ID
7531
9402
HPRD ID
05457
05156
Ensembl ID
ENSG00000108953
ENSG00000100351
Uniprot IDs
P62258
V9HW98
B7Z8E3
O75791
Q6FI14
PDB IDs
2BR9
3UAL
3UBW
6EIH
5GJH
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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