YWHAE and ENKD1

Data Source:
BioGRID (two hybrid)

		YWHAE	ENKD1
Description		tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon	enkurin domain containing 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Cytosol Kinesin Complex Plasma Membrane Focal Adhesion Membrane Melanosome Extracellular Exosome Central Region Of Growth Cone Glutamatergic Synapse	Cytoplasmic Microtubule Microtubule Cytoskeleton Ciliary Base
	Molecular Function	RNA Binding Calcium Channel Regulator Activity Protein Binding Potassium Channel Regulator Activity Enzyme Binding MHC Class II Protein Complex Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Histone Deacetylase Binding Ion Channel Binding Cadherin Binding Protein Heterodimerization Activity Phosphoserine Residue Binding Phosphoprotein Binding Scaffold Protein Binding	Protein Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle MAPK Cascade Regulation Of Heart Rate By Hormone Regulation Of G2/M Transition Of Mitotic Cell Cycle Viral Process Substantia Nigra Development Protein Localization To Nucleus Cellular Response To Heat Hippo Signaling Intracellular Signal Transduction Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Protein Export From Nucleus Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Membrane Repolarization Membrane Organization Membrane Repolarization During Cardiac Muscle Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Ciliary Basal Body-plasma Membrane Docking Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Regulation Of Cellular Response To Heat Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Potassium Ion Transmembrane Transporter Activity Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Negative Regulation Of Peptidyl-serine Dephosphorylation Negative Regulation Of Calcium Ion Export Across Plasma Membrane
Pathways		Activation of BAD and translocation to mitochondria Translocation of SLC2A4 (GLUT4) to the plasma membrane Signaling by Hippo NADE modulates death signalling Regulation of PLK1 Activity at G2/M Transition Regulation of HSF1-mediated heat shock response HSF1 activation Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane RHO GTPases activate PKNs TP53 Regulates Metabolic Genes Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex AURKA Activation by TPX2 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models RAB GEFs exchange GTP for GDP on RABs
Drugs		Fusicoccin Phenethyl Isothiocyanate
Diseases		Lissencephaly (LIS); Miller-Dieker syndrome (MDLS)
GWAS		Atrial fibrillation ( 30061737) High light scatter reticulocyte percentage of red cells ( 32888494) Mean platelet volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Nicotine dependence symptom count ( 25555482) Reaction time ( 29844566) Schizophrenia ( 28991256 30285260)	Refractive error ( 32231278) Schizophrenia ( 25056061 29483656)
Interacting Genes		147 interacting genes: - ABL1 ACD AKAP13 AKAP9 ANKHD1-EIF4EBP3 ANKZF1 ARHGEF2 ARHGEF28 ATP6V0B ATXN1 BAD BCR BEX3 CALM1 CAP2 CASK CASP3 CCDC125 CCR9 CDC25A CDC25B CDK11B CDK14 CDK16 CDKN1B CEP131 CEP95 CGNL1 CHAF1A CHST11 CYSLTR2 DDX54 DISC1 DYRK1A ENKD1 EXO1 FAM13B FAM53C FGF12 FHL1 FTH1 GAPDH GPRIN2 GRAP2 GSTA1 GSTM3 GTF2B HDAC4 HDAC5 HIVEP2 HNRNPC HSF1 HSPB1 IGF1R IL7R ING1 IRAG2 IRS1 IRS2 ITPRID2 KANK1 KCNH2 KCNK15 KCNK3 KCNK9 KIAA0232 KIF1C KLC4 KRT18 LCP2 MAGEB4 MAP3K1 MAP3K10 MAP3K2 MAP3K3 MAP3K5 MAPK7 MCM10 MDM4 METAP2 MSL2 MST1R MT-CO2 MYH10 NAF1 NCOR2 NDEL1 NIN PAPOLA PARD3B PCM1 PIMREG PNLIP POT1 PRC1 PRDX6 PRKCG RAB11FIP2 RAF1 RAP1GAP2 RASAL3 RASGRF1 RBIS RBM14 REM1 RGS3 RIN1 RPA2 RPGR RXFP3 SAMSN1 SH3BP4 SLC8A1 SLC8A2 SLC8A3 SMAGP SNAPIN SNCA SNF8 SORBS2 SRC SYN2 TAF7 TAZ TBC1D3F TBP TCEANC TFDP2 TGFB1 TLK1 TNFAIP3 TOP2A TSC1 TSC2 UBE3A USP43 VIM WNK1 WWTR1 YWHAB YWHAG YWHAH YWHAQ YWHAZ ZC3HC1 ZNF839	207 interacting genes: ABI1 ABI2 ACOT7 AKAP8L ANKRD23 ANKRD49 APP ARMC5 ASB3 AVPI1 BANP BCAS2 BCAS4 BCAT1 BEGAIN BEX3 BHLHB9 BLZF1 BRAT1 C18orf54 C19orf54 C1orf105 CALCOCO1 CALCOCO2 CBY1 CBY2 CCDC102B CCDC13 CCDC136 CCDC28B CCDC85B CDCA4 CDPF1 CDR2 CDSN CEP55 CEP70 CHCHD3 CHRDL2 COA7 CTBP2 CYSRT1 DGCR6 DVL2 DVL3 DYDC1 ECM1 EFHC2 EIF4G1 EYA2 EZHIP FAM102A FAM228A FAM90A1 FCHSD2 FKBP6 FOS FOSB FSD2 GADD45G GADD45GIP1 GET4 GFAP GIGYF1 GOLGA2 GOLGA6A GOLGA6L9 GRHL3 GRIPAP1 HMBOX1 HNRNPH1 HOMEZ HOOK2 HOXA1 HSF2BP HSPB2 HSPB2-C11orf52 ID2 IGF1 IGFBP6 IKBKG IKZF3 JAKMIP1 KIFC3 KLHL20 KLHL26 KRT14 KRT15 KRT31 KRT35 KRT40 KRTAP10-5 KRTAP10-8 KRTAP11-1 KRTAP12-1 KRTAP13-2 KRTAP19-1 KRTAP19-5 KRTAP19-6 KRTAP4-11 KRTAP5-9 KRTAP6-2 LDOC1 LHX3 LIN7B LMO2 LRRC61 LZTS1 MAPK9 MATN4 MDFI MEIS3 MESD METTL27 MID2 MIF4GD MIPOL1 MISP MKRN3 MLH1 MORN3 MORN5 MRNIP MRPL28 MRPL38 MTUS2 MYF5 MYOZ3 N4BP3 NAB2 NBPF22P NBPF6 NCKIPSD NDUFB7 NEFL NFKBIA NHLRC4 NUTM1 OOEP PAK5 PDLIM7 PDZD4 PHC2 PIBF1 PICK1 PIK3R3 PKNOX2 PLSCR1 PNMA1 PNMA2 POLR3C PPP1CC PPP2R3C PRDM14 PRDM6 RAD54B RBCK1 RBM11 RBPMS RCN1 RUBCN RUNDC3A SLC15A2 SNRNP48 SORBS3 SPAG5 SPDEF SPSB3 SRGAP3 SSC4D STAC3 STXBP4 TENT5B TNNI1 TNS2 TOX2 TRAF1 TRAF2 TRAK1 TRGV7 TRIM23 TRIM27 TRIM35 TRIM54 TSC1 TSC22D4 TSEN15 UBXN11 USH1C USH1G USHBP1 USP20 VBP1 VPS37B VWC2 WDR62 WWOX YWHAE ZBTB14 ZC2HC1C ZFP90 ZNF143 ZNF426 ZNF511 ZNF581 ZNF76 ZRANB1
Entrez ID		7531	84080
HPRD ID		05457	13151
Ensembl ID		ENSG00000108953	ENSG00000124074
Uniprot IDs		P62258 V9HW98	Q9H0I2
PDB IDs		2BR9 3UAL 3UBW 6EIH
Enriched GO Terms of Interacting Partners?
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