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ITK and PPIA
Data Source:
BioGRID
(enzymatic study, affinity chromatography technology)
HPRD
(in vivo)
ITK
PPIA
Description
IL2 inducible T cell kinase
peptidylprolyl isomerase A
Image
GO Annotations
Cellular Component
Nucleus
Cytosol
Plasma Membrane
Cell-cell Junction
Extracellular Region
Extracellular Space
Nucleus
Cytoplasm
Cytosol
Focal Adhesion
Membrane
Vesicle
Protein-containing Complex
Secretory Granule Lumen
Intracellular Membrane-bounded Organelle
Extracellular Exosome
Ficolin-1-rich Granule Lumen
Molecular Function
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Protein Binding
ATP Binding
Metal Ion Binding
RNA Binding
Peptidyl-prolyl Cis-trans Isomerase Activity
Integrin Binding
Protein Binding
Cyclosporin A Binding
Virion Binding
Unfolded Protein Binding
Heparan Sulfate Binding
Biological Process
Cytokine Production
NK T Cell Differentiation
Adaptive Immune Response
Cellular Defense Response
Signal Transduction
Activation Of Phospholipase C Activity
Intracellular Signal Transduction
Peptidyl-tyrosine Autophosphorylation
Fc-epsilon Receptor Signaling Pathway
T Cell Activation
Gamma-delta T Cell Activation
T Cell Receptor Signaling Pathway
B Cell Receptor Signaling Pathway
Activation Of MAPK Activity
Protein Peptidyl-prolyl Isomerization
Negative Regulation Of Protein Phosphorylation
Positive Regulation Of Protein Phosphorylation
RNA-dependent DNA Biosynthetic Process
Protein Folding
Negative Regulation Of Protein Kinase Activity
Apoptotic Process
Viral Life Cycle
Uncoating Of Virus
Fusion Of Virus Membrane With Host Plasma Membrane
Virion Assembly
Viral Release From Host Cell
Platelet Activation
Neutrophil Chemotaxis
Leukocyte Chemotaxis
Activation Of Protein Kinase B Activity
Negative Regulation Of Stress-activated MAPK Cascade
Lipid Droplet Organization
Cellular Response To Oxidative Stress
Positive Regulation Of Protein Dephosphorylation
Interleukin-12-mediated Signaling Pathway
Endothelial Cell Activation
Neutrophil Degranulation
Regulation Of Viral Genome Replication
Positive Regulation Of Viral Genome Replication
Positive Regulation Of Protein Secretion
Leukocyte Migration
Positive Regulation Of NF-kappaB Transcription Factor Activity
Cell Adhesion Molecule Production
Negative Regulation Of Protein K48-linked Ubiquitination
Platelet Aggregation
Establishment Of Integrated Proviral Latency
Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway
Negative Regulation Of Viral Life Cycle
Regulation Of Apoptotic Signaling Pathway
Pathways
Generation of second messenger molecules
FCERI mediated Ca+2 mobilization
FCERI mediated Ca+2 mobilization
Platelet degranulation
Uncoating of the HIV Virion
Budding and maturation of HIV virion
Integration of provirus
Early Phase of HIV Life Cycle
Minus-strand DNA synthesis
Plus-strand DNA synthesis
Binding and entry of HIV virion
Assembly Of The HIV Virion
APOBEC3G mediated resistance to HIV-1 infection
Calcineurin activates NFAT
Basigin interactions
Neutrophil degranulation
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Drugs
Staurosporine
Pazopanib
Fostamatinib
Zanubrutinib
Cyclosporine
Proline
(3r)-1-Acetyl-3-Methylpiperidine
Ethyl Oxo(Piperidin-1-Yl)Acetate
Sanglifehrin A
Copper
Artenimol
Diseases
GWAS
Asthma (
31959851
)
Daytime sleep phenotypes (
27126917
)
Eosinophil counts (
32888494
)
Heel bone mineral density (
30598549
)
Personality traits in bipolar disorder (
21368711
)
T-Cell Immunoglobulin and Mucin domain 1 levels (
32460577
)
Mean reticulocyte volume (
32888494
)
Red blood cell count (
32888494
)
Interacting Genes
34 interacting genes:
BLNK
BMX
BTK
CBL
CD28
DOK1
EGFR
ERBB2
ERBB3
ERBB4
FASLG
FGFR1
FYN
GAB1
GRB2
HNRNPK
IKBKG
KHDRBS1
KPNA2
LAT
LCK
LCP2
MET
PLCG1
PLCG2
PPIA
SH2D2A
SMAD4
SMURF1
SOCS1
SPRR2A
SRC
TGFBR1
WAS
27 interacting genes:
APP
BSG
CD99
ERCC6
ERRFI1
G3BP1
ITK
JAK2
LIG4
LNX1
N4BP2L2
NOTCH3
PAXIP1
PRLR
PRR13
PRSS23
PTPRN
RB1
S100A8
SRPK1
SRPK2
SUPT5H
TCF4
TERT
USP4
WBP4
YY1
Entrez ID
3702
5478
HPRD ID
01746
00457
Ensembl ID
ENSG00000113263
ENSG00000196262
Uniprot IDs
Q08881
P62937
V9HWF5
PDB IDs
1SM2
1SNU
1SNX
2E6I
2LMJ
2YUQ
3MIY
3MJ1
3MJ2
3QGW
3QGY
3T9T
3V5J
3V5L
3V8T
3V8W
4HCT
4HCU
4HCV
4KIO
4L7S
4M0Y
4M0Z
4M12
4M13
4M14
4M15
4MF0
4MF1
4PP9
4PPA
4PPB
4PPC
4PQN
4QD6
4RFM
1AK4
1AWQ
1AWR
1AWS
1AWT
1AWU
1AWV
1BCK
1CWA
1CWB
1CWC
1CWF
1CWH
1CWI
1CWJ
1CWK
1CWL
1CWM
1CWO
1FGL
1M63
1M9C
1M9D
1M9E
1M9F
1M9X
1M9Y
1MF8
1MIK
1NMK
1OCA
1RMH
1VBS
1VBT
1W8L
1W8M
1W8V
1YND
1ZKF
2ALF
2CPL
2CYH
2MS4
2MZU
2N0T
2RMA
2RMB
2X25
2X2A
2X2C
2X2D
2XGY
3CYH
3CYS
3K0M
3K0N
3K0O
3K0P
3K0Q
3K0R
3ODI
3ODL
3RDD
4CYH
4IPZ
4N1M
4N1N
4N1O
4N1P
4N1Q
4N1R
4N1S
4YUG
4YUH
4YUI
4YUJ
4YUK
4YUL
4YUM
4YUN
4YUO
4YUP
5CYH
5F66
5FJB
5KUL
5KUN
5KUO
5KUQ
5KUR
5KUS
5KUU
5KUV
5KUW
5KUZ
5KV0
5KV1
5KV2
5KV3
5KV4
5KV5
5KV6
5KV7
5LUD
5NOQ
5NOR
5NOS
5NOT
5NOU
5NOV
5NOW
5NOX
5NOY
5NOZ
5T9U
5T9W
5T9Z
5TA2
5TA4
5WC7
6BTA
6GJI
6GJJ
6GJL
6GJM
6GJN
6GJP
6GJR
6GJY
6GS6
6I42
6U5C
6U5D
6U5E
6U5G
6X3R
6X3Y
6X4M
6X4N
6X4O
6X4P
6X4Q
6Y9V
6Y9W
6Y9X
6Y9Y
6Y9Z
6ZDJ
Enriched GO Terms of Interacting Partners
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