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VCP and RNF115
Data Source:
BioGRID
(two hybrid)
VCP
RNF115
Description
valosin containing protein
ring finger protein 115
Image
No pdb structure
GO Annotations
Cellular Component
Proteasome Complex
Extracellular Region
Nucleus
Nucleoplasm
Cytoplasm
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Lipid Droplet
Cytosol
Cytoplasmic Stress Granule
Protein-containing Complex
VCP-NPL4-UFD1 AAA ATPase Complex
Secretory Granule Lumen
Azurophil Granule Lumen
Site Of Double-strand Break
Derlin-1 Retrotranslocation Complex
Intracellular Membrane-bounded Organelle
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Glutamatergic Synapse
Ficolin-1-rich Granule Lumen
ATPase Complex
VCP-NSFL1C Complex
Cytosol
Molecular Function
RNA Binding
Protein Binding
ATP Binding
Lipid Binding
ATPase Activity
Protein Phosphatase Binding
Protein Domain Specific Binding
Polyubiquitin Modification-dependent Protein Binding
Ubiquitin Protein Ligase Binding
Deubiquitinase Activator Activity
K48-linked Polyubiquitin Modification-dependent Protein Binding
MHC Class I Protein Binding
Identical Protein Binding
ADP Binding
Ubiquitin-like Protein Ligase Binding
BAT3 Complex Binding
Ubiquitin-specific Protease Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Metal Ion Binding
Ubiquitin Protein Ligase Activity
Biological Process
DNA Repair
Double-strand Break Repair
Protein Folding
NADH Metabolic Process
Endoplasmic Reticulum To Golgi Vesicle-mediated Transport
Autophagy
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Cellular Response To DNA Damage Stimulus
Proteasomal Protein Catabolic Process
Positive Regulation Of Mitochondrial Membrane Potential
Macroautophagy
Protein Ubiquitination
Protein Deubiquitination
Viral Genome Replication
Translesion Synthesis
Ubiquitin-dependent ERAD Pathway
Endoplasmic Reticulum Unfolded Protein Response
Retrograde Protein Transport, ER To Cytosol
Positive Regulation Of Protein-containing Complex Assembly
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway
Cellular Response To Heat
Stress Granule Disassembly
Interstrand Cross-link Repair
ERAD Pathway
Regulation Of Apoptotic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Neutrophil Degranulation
Establishment Of Protein Localization
Positive Regulation Of Protein Catabolic Process
Negative Regulation Of Smoothened Signaling Pathway
ATP Metabolic Process
Regulation Of Synapse Organization
Mitotic Spindle Disassembly
Transmembrane Transport
Endoplasmic Reticulum Stress-induced Pre-emptive Quality Control
Aggresome Assembly
Error-free Translesion Synthesis
ER-associated Misfolded Protein Catabolic Process
Flavin Adenine Dinucleotide Catabolic Process
Positive Regulation Of Canonical Wnt Signaling Pathway
Autophagosome Maturation
Protein-DNA Covalent Cross-linking Repair
Positive Regulation Of Protein K63-linked Deubiquitination
Positive Regulation Of Lys63-specific Deubiquitinase Activity
Regulation Of Aerobic Respiration
Cellular Response To Arsenite Ion
Positive Regulation Of Oxidative Phosphorylation
Regulation Of Protein Localization To Chromatin
Positive Regulation Of Ubiquitin-specific Protease Activity
Positive Regulation Of ATP Biosynthetic Process
Protein Polyubiquitination
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway
Protein Autoubiquitination
Protein K63-linked Ubiquitination
Protein K48-linked Ubiquitination
Pathways
Translesion Synthesis by POLH
HSF1 activation
ABC-family proteins mediated transport
N-glycan trimming in the ER and Calnexin/Calreticulin cycle
Hedgehog ligand biogenesis
Hh mutants are degraded by ERAD
Defective CFTR causes cystic fibrosis
Josephin domain DUBs
Ovarian tumor domain proteases
Neutrophil degranulation
E3 ubiquitin ligases ubiquitinate target proteins
Protein methylation
Aggrephagy
Attachment and Entry
Attachment and Entry
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Phosphoaminophosphonic Acid-Adenylate Ester
Phenethyl Isothiocyanate
Diseases
Frontotemporal lobar degeneration (FTLD), including: Pick disease of brain; Frontotemporal dementia (FTD); Ubiquitin-positive frontotemporal dementia (UP-FTD); Progressive supranuclear palsy type 1 (PSNP1); Inclusion body myopathy with early-onset paget disease and frontotemporal dementia (IBMPFD); Frontotemporal dementia, chromosome 3-linked (FTD3)
GWAS
Response to quetiapine in schizophrenia (
29503163
)
Apolipoprotein A1 levels (
32203549
)
Breast cancer (
25751625
29059683
)
HDL cholesterol levels (
32203549
)
Platelet distribution width (
32888494
)
Interacting Genes
91 interacting genes:
ABHD17C
AMFR
ANKRD13A
AR
ASPSCR1
ATG5
ATXN1
ATXN3
ATXN7
BRCA1
BRSK2
BUD23
CEP19
CLUAP1
CRMP1
CSTF1
DERL1
DGCR6
DTNB
ELAVL1
EPSTI1
ESR1
FAF2
FAM104A
GZMK
HDAC6
HERPUD1
HTT
INSIG1
INSIG2
JAK2
LINC01554
LNX1
LZIC
MAPK8IP2
METTL17
NDRG1
NF1
NFKBIA
NGLY1
NOD2
NSFL1C
NTAQ1
NUB1
OPTN
PIK3R3
PLAA
PPP1R11
PRKCD
PSMA1
PSMA7
PSMC1
PTPN3
RNF115
RNF19A
RNF8
RPL9
RPS6KA1
SELENOS
SH2D2A
SLC43A3
STUB1
STX5
SUMO4
SVIP
TOM1L1
TOMM34
TRIM54
UBASH3A
UBC
UBE4A
UBE4B
UBOX5
UBXN10
UBXN11
UBXN2A
UBXN2B
UBXN4
UBXN6
UBXN7
UFD1
USP7
VAMP2
VCPIP1
VCPKMT
WAC
WRN
XAF1
YOD1
YWHAZ
ZBTB25
32 interacting genes:
AKT1
APP
ATN1
CDK10
CST3
DAZAP2
DOCK4
EGFR
FOLR3
HRAS
IGHA1
MDM4
MFAP4
NFKBIA
RAB7A
RAD23A
RPL18A
TTR
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E1
UBE2E2
UBE2E3
UBE2I
UBE2N
UBE2W
USP9X
VCP
ZNRD2
Entrez ID
7415
27246
HPRD ID
03013
18328
Ensembl ID
ENSG00000165280
ENSG00000265491
Uniprot IDs
P55072
V9HW80
Q9Y4L5
PDB IDs
3EBB
3HU1
3HU2
3HU3
3QC8
3QQ7
3QQ8
3QWZ
3TIW
4KDI
4KDL
4KLN
4KO8
4KOD
4P0A
5B6C
5C18
5C19
5C1A
5C1B
5DYG
5DYI
5EPP
5FTJ
5FTK
5FTL
5FTM
5FTN
5GLF
5IFS
5IFW
5KIW
5KIY
5X4L
6G2V
6G2W
6G2X
6G2Y
6G2Z
6G30
6HD0
6MCK
Enriched GO Terms of Interacting Partners
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