NUB1 and NEDD8

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		NUB1	NEDD8
Description		negative regulator of ubiquitin like proteins 1	NEDD8 ubiquitin like modifier
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GO Annotations	Cellular Component	Nucleoplasm Nucleolus Cytosol	Nucleus Nucleoplasm Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Protein Binding	Protein Binding Protein Tag Ubiquitin Protein Ligase Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Response To Interferon-gamma Response To Tumor Necrosis Factor Post-translational Protein Modification Regulation Of Ubiquitin-dependent Protein Catabolic Process	Regulation Of Transcription By RNA Polymerase II Cellular Protein Modification Process Proteolysis Ubiquitin-dependent Protein Catabolic Process Cellular Iron Ion Homeostasis Protein Localization Anatomical Structure Morphogenesis Response To Organic Cyclic Compound Protein Ubiquitination Protein Deubiquitination Modification-dependent Protein Catabolic Process Regulation Of Proteolysis Post-translational Protein Modification Protein Neddylation
Pathways			TGF-beta receptor signaling activates SMADs UCH proteinases Cargo recognition for clathrin-mediated endocytosis Neddylation Iron uptake and transport
Drugs
Diseases
GWAS		Body fat mass ( 28552196) Carotid plaque burden ( 28282560) Eyebrow thickness ( 26926045)	Mean corpuscular volume ( 29403010) Systolic blood pressure (cigarette smoking interaction) ( 26752167)
Interacting Genes		12 interacting genes: AIPL1 COPB1 FANCA NEDD8 PSMD2 PSMD4 SF3B4 SNCAIP UBD UBE2K UFD1 VCP	42 interacting genes: AHR ARIH2 ATXN3 CBLB CDC34 COPS5 COPS6 CTRC CUL1 CUL2 CUL3 CUL4B DNMT3B GARS1 GHR HGS HIF1A HSPA4 N4BP1 NAE1 NUB1 OTUB1 OTUD5 PARP1 POLI PSMA6 PSMD4 PTK2 RAD23A SENP8 SMURF1 TP53 UBA2 UBA3 UBE2K UBE2M UBL7 UBQLN1 UBXN7 UCHL1 UCHL3 YAF2
Entrez ID		51667	4738
HPRD ID		07450	04412
Ensembl ID		ENSG00000013374	ENSG00000129559
Uniprot IDs		A0A090N8Q5 H3BM14 H3BM74 Q9Y5A7	Q15843
PDB IDs		1WJU	1NDD 1R4M 1R4N 1XT9 2BKR 2KO3 2N7K 2NVU 3DBH 3DBL 3DBR 3DQV 3GZN 4F8C 4FBJ 4HCP 4P5O 6R7F 6R7I 6TTU
Enriched GO Terms of Interacting Partners?
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