GZMK and UFD1

Data Source:
BioGRID (enzymatic study)

		GZMK	UFD1
Description		granzyme K	ubiquitin recognition factor in ER associated degradation 1
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GO Annotations	Cellular Component	Extracellular Region	Nucleus Nucleoplasm Cytosol VCP-NPL4-UFD1 AAA ATPase Complex UFD1-NPL4 Complex
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Serine-type Peptidase Activity	Thiol-dependent Ubiquitin-specific Protease Activity Signaling Receptor Binding Protein Binding Polyubiquitin Modification-dependent Protein Binding K48-linked Polyubiquitin Modification-dependent Protein Binding Protein-containing Complex Binding ATPase Binding
	Biological Process	Proteolysis	Skeletal System Development Ubiquitin-dependent Protein Catabolic Process Protein Deubiquitination Protein Phosphopantetheinylation Ubiquitin-dependent ERAD Pathway Retrograde Protein Transport, ER To Cytosol Negative Regulation Of Type I Interferon Production Negative Regulation Of RIG-I Signaling Pathway Error-free Translesion Synthesis ER-associated Misfolded Protein Catabolic Process
Pathways			Translesion Synthesis by POLH Ub-specific processing proteases
Drugs
Diseases
GWAS		Blood protein levels ( 30072576 29875488)
Interacting Genes		13 interacting genes: ACTG1 APEX1 GOLGA2 HMGB2 HNRNPK LIG4 NPLOC4 PNKP SET TMBIM6 TUBB3 UFD1 VCP	23 interacting genes: A2M AMFR ANAPC2 CHMP2A F13A1 GZMK HSPB1 IGHM LRRK2 MAP3K1 MASP1 NGFR NPLOC4 NUB1 PIK3CA PPHLN1 SNX1 TAF1C TIAM2 TP53 UBC UBXN6 VCP
Entrez ID		3003	7353
HPRD ID		02872	06778
Ensembl ID		ENSG00000113088	ENSG00000070010
Uniprot IDs		P49863	Q541A5 Q92890
PDB IDs		1MZA 1MZD	2YUJ 5B6C 5C1B
Enriched GO Terms of Interacting Partners?
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