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PTEN and PPP2CA
Data Source:
BioGRID
(pull down)
PTEN
PPP2CA
Description
phosphatase and tensin homolog
protein phosphatase 2 catalytic subunit alpha
Image
GO Annotations
Cellular Component
Extracellular Region
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Cytosol
Plasma Membrane
Cytoplasmic Side Of Plasma Membrane
Apical Plasma Membrane
PML Body
Myelin Sheath Adaxonal Region
Cell Projection
Neuron Projection
Dendritic Spine
Schmidt-Lanterman Incisure
Postsynaptic Membrane
Postsynaptic Cytosol
Protein Phosphatase Type 2A Complex
Chromosome, Centromeric Region
Spindle Pole
Nucleus
Mitochondrion
Cytosol
Plasma Membrane
Microtubule Cytoskeleton
Membrane
Membrane Raft
Synapse
Extracellular Exosome
Molecular Function
Phosphatidylinositol-3-phosphatase Activity
Phosphoprotein Phosphatase Activity
Protein Serine/threonine Phosphatase Activity
Protein Tyrosine Phosphatase Activity
Platelet-derived Growth Factor Receptor Binding
Protein Binding
Protein Tyrosine/serine/threonine Phosphatase Activity
Lipid Binding
Anaphase-promoting Complex Binding
Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity
Enzyme Binding
PDZ Domain Binding
Ionotropic Glutamate Receptor Binding
Identical Protein Binding
Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity
Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity
Protein Serine Phosphatase Activity
Protein Threonine Phosphatase Activity
Ubiquitin-specific Protease Binding
Protein Tyrosine Kinase Binding
Phosphoprotein Phosphatase Activity
Protein Serine/threonine Phosphatase Activity
Protein Binding
Protein C-terminus Binding
Metal Ion Binding
Protein Heterodimerization Activity
Tau Protein Binding
GABA Receptor Binding
Protein Serine Phosphatase Activity
Protein Threonine Phosphatase Activity
Biological Process
Angiogenesis
Negative Regulation Of Protein Phosphorylation
Regulation Of B Cell Apoptotic Process
Transcription Initiation From RNA Polymerase II Promoter
Protein Dephosphorylation
Phosphatidylinositol Biosynthetic Process
Apoptotic Process
Neuron-neuron Synaptic Transmission
Synapse Assembly
Central Nervous System Development
Heart Development
Aging
Response To Nutrient
Learning Or Memory
Memory
Locomotory Behavior
Positive Regulation Of Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Response To Glucose
Response To Zinc Ion
Positive Regulation Of Gene Expression
Positive Regulation Of Cardiac Muscle Cell Apoptotic Process
Negative Regulation Of Epithelial To Mesenchymal Transition
Regulation Of Neuron Projection Development
Negative Regulation Of Neuron Projection Development
Phosphatidylinositol 3-kinase Signaling
Negative Regulation Of Phosphatidylinositol 3-kinase Signaling
Response To Activity
Dephosphorylation
Cell Migration
Protein Deubiquitination
Dentate Gyrus Development
Central Nervous System Neuron Axonogenesis
Negative Regulation Of Cell Migration
Adult Behavior
Negative Regulation Of Myelination
Regulation Of Protein Stability
Regulation Of Synaptic Transmission, GABAergic
Central Nervous System Myelin Maintenance
Response To Estradiol
Regulation Of Cellular Component Size
Cellular Response To Insulin Stimulus
Regulation Of Myeloid Cell Apoptotic Process
Negative Regulation Of Peptidyl-serine Phosphorylation
Response To ATP
Multicellular Organismal Response To Stress
Social Behavior
Peptidyl-tyrosine Dephosphorylation
Response To Drug
Maternal Behavior
Negative Regulation Of Apoptotic Process
Protein Kinase B Signaling
Endothelial Cell Migration
Inositol Phosphate Metabolic Process
Cellular Response To Leptin Stimulus
Locomotor Rhythm
Positive Regulation Of Neuron Differentiation
Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Negative Regulation Of Cell Size
Negative Regulation Of Organ Growth
Response To Arsenic-containing Substance
Inositol Phosphate Dephosphorylation
Phosphatidylinositol Dephosphorylation
Platelet-derived Growth Factor Receptor Signaling Pathway
Negative Regulation Of Axon Regeneration
Cardiac Muscle Tissue Development
Forebrain Morphogenesis
Brain Morphogenesis
Cell Motility
Negative Regulation Of Epithelial Cell Proliferation
Negative Regulation Of Phagocytosis
Negative Regulation Of Axonogenesis
Protein Stabilization
Positive Regulation Of DNA-binding Transcription Factor Activity
Negative Regulation Of Keratinocyte Migration
Negative Regulation Of Focal Adhesion Assembly
Regulation Of Protein Kinase B Signaling
Negative Regulation Of Protein Kinase B Signaling
Rhythmic Synaptic Transmission
Negative Regulation Of Cardiac Muscle Cell Proliferation
Canonical Wnt Signaling Pathway
Synapse Maturation
Prepulse Inhibition
Male Mating Behavior
Long-term Synaptic Potentiation
Long-term Synaptic Depression
Prostate Gland Growth
Dendritic Spine Morphogenesis
Negative Regulation Of Dendritic Spine Morphogenesis
Negative Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Electrical Stimulus
Cellular Response To Ethanol
Cellular Response To Hypoxia
Negative Regulation Of Ribosome Biogenesis
Negative Regulation Of Cell Aging
Negative Regulation Of Excitatory Postsynaptic Potential
Presynaptic Membrane Assembly
Postsynaptic Density Assembly
Negative Regulation Of Potassium Ion Transmembrane Transporter Activity
Negative Regulation Of Cell Cycle G1/S Phase Transition
Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells
Positive Regulation Of TRAIL-activated Apoptotic Signaling Pathway
Positive Regulation Of Ubiquitin Protein Ligase Activity
Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Cellular Response To Nerve Growth Factor Stimulus
Cellular Response To Insulin-like Growth Factor Stimulus
Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Negative Regulation Of Signaling Receptor Activity
Positive Regulation Of Excitatory Postsynaptic Potential
Negative Regulation Of Synaptic Vesicle Clustering
Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay
Inactivation Of MAPK Activity
Regulation Of Protein Phosphorylation
Regulation Of DNA Replication
Regulation Of Transcription, DNA-templated
Protein Dephosphorylation
Ceramide Metabolic Process
Apoptotic Process
Mitotic Nuclear Envelope Reassembly
Mesoderm Development
RNA Splicing
Response To Organic Substance
Response To Lead Ion
Negative Regulation Of Epithelial To Mesenchymal Transition
Second-messenger-mediated Signaling
Regulation Of Wnt Signaling Pathway
Regulation Of Cell Adhesion
Negative Regulation Of Cell Growth
Peptidyl-threonine Dephosphorylation
Regulation Of Growth
Negative Regulation Of Tyrosine Phosphorylation Of STAT Protein
Regulation Of Cell Differentiation
Meiotic Cell Cycle
Peptidyl-serine Dephosphorylation
Positive Regulation Of Protein Serine/threonine Kinase Activity
Regulation Of Microtubule Binding
Positive Regulation Of Microtubule Binding
Pathways
Synthesis of PIPs at the plasma membrane
Synthesis of IP3 and IP4 in the cytosol
Negative regulation of the PI3K/AKT network
Downstream TCR signaling
TP53 Regulates Metabolic Genes
PTEN Loss of Function in Cancer
Ub-specific processing proteases
Ovarian tumor domain proteases
Regulation of PTEN mRNA translation
Regulation of PTEN localization
Regulation of PTEN stability and activity
Transcriptional Regulation by MECP2
Inhibition of replication initiation of damaged DNA by RB1/E2F1
Spry regulation of FGF signaling
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Integration of energy metabolism
PP2A-mediated dephosphorylation of key metabolic factors
DARPP-32 events
Degradation of beta-catenin by the destruction complex
Beta-catenin phosphorylation cascade
ERK/MAPK targets
ERKs are inactivated
MASTL Facilitates Mitotic Progression
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
Initiation of Nuclear Envelope (NE) Reformation
CTLA4 inhibitory signaling
Platelet sensitization by LDL
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Signaling by GSK3beta mutants
S33 mutants of beta-catenin aren't phosphorylated
S37 mutants of beta-catenin aren't phosphorylated
S45 mutants of beta-catenin aren't phosphorylated
T41 mutants of beta-catenin aren't phosphorylated
APC truncation mutants have impaired AXIN binding
AXIN missense mutants destabilize the destruction complex
Truncations of AMER1 destabilize the destruction complex
RHO GTPases Activate Formins
RAF activation
Negative regulation of MAPK pathway
Regulation of TP53 Degradation
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Mitotic Prometaphase
Cyclin D associated events in G1
Cyclin A/B1/B2 associated events during G2/M transition
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism
EML4 and NUDC in mitotic spindle formation
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Phosphatidylethanolamine
Vitamin E
2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid
(2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoic acid
Diseases
Vulvar cancer
Prostate cancer
Endometrial Cancer
Glioma
Small cell lung cancer
Breast cancer
Hepatocellular carcinoma
Malignant melanoma
GWAS
Ambidextrousness (
32989287
)
Birth weight (
31043758
)
Eosinophil counts (
32888494
27863252
)
Eosinophil percentage of granulocytes (
27863252
)
Eosinophil percentage of white cells (
32888494
27863252
)
Height (
31562340
)
Lymphocyte percentage of white cells (
32888494
)
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Mercury levels (
26025379
)
Multiple sclerosis (
31604244
)
Neutrophil count (
32888494
)
Neutrophil percentage of granulocytes (
27863252
)
Neutrophil percentage of white cells (
32888494
)
Periodontitis (Mean PAL) (
24024966
)
Platelet count (
32888494
)
Plateletcrit (
32888494
)
Psoriasis (
28537254
)
Pulse pressure (
27841878
)
Red blood cell count (
32888494
)
Sum eosinophil basophil counts (
27863252
)
Thyroid stimulating hormone levels (
30367059
32769997
)
Type 2 diabetes (
24509480
32499647
)
Type 2 diabetes (adjusted for BMI) (
30297969
)
White blood cell count (
32888494
)
White blood cell count (basophil) (
29403010
)
Interacting Genes
356 interacting genes:
AATK
ABCF2
ACTL6A
ADAR
AFP
AKAP12
AKT1
ALYREF
AMOT
ANAPC10
ANAPC7
ANG
ANP32B
ANP32E
ANXA2
AR
ARF4
ARMCX3
ASCC3
ATP5F1A
ATP5F1C
BCAR1
BEX1
BUB3
CAD
CALM1
CAMK2G
CAV1
CCDC180
CCDC47
CCND2
CCT2
CCT3
CCT4
CCT6A
CCT8
CDC27
CEP170
CEP97
CFL1
CHD4
CHGB
CMAS
COPA
COPB1
COPS6
CSNK1A1
CSNK2A1
CSNK2A2
CUL4B
CXCL1
DAP3
DAXX
DBN1
DCAF11
DCAF13
DDB1
DDOST
DDX1
DDX21
DDX24
DDX47
DDX50
DHX15
DHX9
DLC1
DLG1
DNAJA1
DNAJA2
DNAJA3
DNAJB6
DNAJC10
DPM1
DRG1
DSP
EEF2
EIF4E
EIF6
EPHA2
EPRS1
ERBB3
ESR1
EXOSC1
EXOSC2
EXOSC4
EXOSC5
EXOSC7
FARSA
FARSB
FASN
FBL
FBXW11
FOXK1
FUBP3
GEMIN4
GNAI1
GNAI2
GNB4
GNL3
GPC4
GSTM2
GTF3C2
GTF3C3
GTF3C5
H2AC4
HADHA
HBA1
HNRNPA1
HNRNPA3
HNRNPAB
HNRNPUL1
HSD17B1
HSD17B10
HSP90AB1
HSP90B1
HSPA4
HSPA4L
HSPA8
HSPBP1
HSPD1
HSPH1
IL24
ILF2
ILF3
INS
IPO5
IPO7
IRS4
ITPRID2
JUP
KBTBD4
KDM1A
KPNB1
LATS1
LGALS1
LIMA1
LINC00839
LINC01198
LINC02023
LMNB1
LRPPRC
LTV1
MAGED2
MAGI2
MAGI3
MAP2K3
MAST1
MAST2
MAST3
MATR3
MCM2
MCM3
MCM5
MCRS1
MDN1
METTL26
MKI67
MME
MPRIP
MRPS22
MRPS23
MRPS27
MRPS28
MRPS7
MRPS9
MSH6
MTHFD2
MVP
MYBBP1A
MYC
MYH10
MYL12A
MYO1B
MYO1C
MYO1D
MYOF
NACA
NCBP1
NCF1
NDFIP1
NGB
NOP56
NOP58
NPM3
NUMB
OSGIN1
OTUD3
PBK
PBRM1
PCNA
PDGFRB
PELO
PELP1
PHB
PHB2
PKM
PLEC
PLK1
POLDIP2
POLR1A
POLR2A
POLR2B
POLR2H
POP1
PPL
PPP1CA
PPP2CA
PRDX1
PRDX3
PRKDC
PRPF19
PRPF8
PSMD3
PSMD4
PSMD7
PTDSS1
PTK2
PTK7
PURA
PXN
QPCTL
RAD21
RANBP2
RANGAP1
RBBP5
RBM4
RCC2
RCN1
RFC3
RFC4
RFC5
RING1
RPL10
RPL10A
RPL12
RPL13
RPL13A
RPL14
RPL17
RPL18A
RPL21
RPL22
RPL22L1
RPL23
RPL23A
RPL27
RPL27A
RPL28
RPL30
RPL31
RPL32
RPL34
RPL36
RPL38
RPL7
RPLP0
RPLP2
RPN2
RPP30
RPP38
RPP40
RPS11
RPS13
RPS15
RPS15A
RPS17
RPS2
RPS20
RPS23
RPS25
RPS26
RPS27
RPS27A
RPS3
RPS4X
RPS5
RPS6
RPS9
RSL1D1
S100A8
S100A9
SDC1
SDC4
SDCBP
SEC61A1
SET
SETX
SIN3A
SIRT4
SKP1
SLC25A1
SLC25A13
SLC25A3
SLC25A5
SLC9A3R1
SLC9A3R2
SMARCA4
SMARCA5
SMC2
SMC4
SMCHD1
SNAI1
SNRNP200
SNRPA1
SNRPB2
SNRPD1
SNTB2
SNX27
SPTAN1
SPTBN1
SRP14
SSB
SSR4
SSRP1
STAG2
STK11
STRAP
STUB1
SUDS3
SUGP2
TCF25
TCP1
TECR
TERF2IP
THOC2
THOC3
THOC6
TMEFF1
TNKS
TNKS2
TP53
TRIM28
TRMO
TUBA1B
TUBB
TUBB4B
TUFM
TWIST1
TXN
U2AF1
UBE2D3
UBE2I
UBE2L3
UBE2S
UPF1
USP7
USP9X
UTP14A
UTRN
XRCC5
XRCC6
YAP1
YES1
YTHDC2
YTHDF2
ZNF326
96 interacting genes:
ADCY8
AKAP6
AKT1
AKT3
AMOTL2
APC
AXIN1
BCL2
BEST1
BMPR1B
BRAF
C3orf36
CAD
CAMK1
CARD11
CAV1
CCNG1
CCNG2
CDC42BPB
CDK2
CDK6
CDKN2C
CEBPA
CHEK2
CLPP
CSNK2B
CXCR2
DELEC1
DVL3
EEF2
EIF4EBP1
ETF1
FCAR
GABRB3
GAD1
GOLGA2
HTT
IGBP1
ISYNA1
JAK2
KISS1R
L3MBTL3
MAPK1
MAPK3
MAPT
MID1
MRPS26
MYC
MYH9
NME2
NOSIP
NXN
PACS1
PAK1
PIM1
PPP1CA
PPP2R1A
PPP2R1B
PPP2R2A
PPP2R3B
PPP2R5B
PPP2R5C
PPP2R5E
PRKAA1
PRKCD
PTEN
PTN
PXN
PYGM
RACGAP1
RBL2
RELA
RHO
RHOB
RORC
RPS6KB1
RRAS
SET
SGK1
SGO1
SGO2
STAT5A
STAT5B
STRN
TIAM1
TLX1
TP53
TRIM28
TRIM35
TRIP13
TSC2
UBAP2
VAC14
VDR
XRN1
YPEL3
Entrez ID
5728
5515
HPRD ID
03431
08912
Ensembl ID
ENSG00000171862
ENSG00000113575
Uniprot IDs
F6KD01
P60484
B3KUN1
P67775
PDB IDs
1D5R
2KYL
4O1V
5BUG
5BZX
5BZZ
2IAE
2IE3
2IE4
2NPP
2NYL
2NYM
3C5W
3DW8
3FGA
3K7V
3K7W
3P71
4I5L
4I5N
4IYP
4LAC
5W0W
6NTS
Enriched GO Terms of Interacting Partners
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