DNAJC7 and RAD1

Data Source:
HPRD (in vitro, in vivo)

		DNAJC7	RAD1
Description		DnaJ heat shock protein family (Hsp40) member C7	RAD1 checkpoint DNA exonuclease
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Cytoskeleton Membrane Extracellular Exosome	Nucleus Nucleoplasm Chromosome Checkpoint Clamp Complex Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding Heat Shock Protein Binding	Damaged DNA Binding Protein Binding 3'-5' Exonuclease Activity Exodeoxyribonuclease III Activity
	Biological Process	Protein Folding Chaperone Cofactor-dependent Protein Refolding Regulation Of Cellular Response To Heat	DNA Damage Checkpoint DNA Replication DNA Repair Cellular Response To DNA Damage Stimulus Substantia Nigra Development Meiotic Recombination Checkpoint Cellular Response To Ionizing Radiation Nucleic Acid Phosphodiester Bond Hydrolysis Regulation Of Signal Transduction By P53 Class Mediator
Pathways		Regulation of HSF1-mediated heat shock response	Activation of ATR in response to replication stress HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint
Drugs
Diseases
GWAS			Daytime sleep phenotypes ( 27126917)
Interacting Genes		12 interacting genes: DISC1 HSP90AA1 HUS1 MKNK1 NF1 RAD1 RAD9A SMAD2 SMAD9 SMURF1 TP53 UBE4B	24 interacting genes: COPS5 CSNK2A1 CSNK2A2 DNAJC7 FEN1 HUS1 HUS1B MAP1LC3B MSH2 MSH3 MSH6 NEIL1 OGG1 POLB PRKN RAD17 RAD9B RHNO1 RPA1 RPA2 SIRT6 TDG TOPBP1 WRN
Entrez ID		7266	5810
HPRD ID		07046	04400
Ensembl ID		ENSG00000168259	ENSG00000113456
Uniprot IDs		Q99615	A0A024R045 O60671
PDB IDs			3A1J 3G65 3GGR 6J8Y
Enriched GO Terms of Interacting Partners?
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