C2 and STOM

Data Source:
BioGRID (two hybrid)

		C2	STOM
Description		complement C2	stomatin
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Exosome	Extracellular Space Mitochondrion Endoplasmic Reticulum Cytoskeleton Plasma Membrane Integral Component Of Plasma Membrane Membrane Vesicle Azurophil Granule Membrane Specific Granule Membrane Melanosome Membrane Raft Perinuclear Region Of Cytoplasm Extracellular Exosome Tertiary Granule Membrane Blood Microparticle
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Metal Ion Binding	Protein Binding Identical Protein Binding Protein Homodimerization Activity RNA Polymerase Binding
	Biological Process	Proteolysis Complement Activation Complement Activation, Classical Pathway Response To Nutrient Regulation Of Complement Activation Innate Immune Response Positive Regulation Of Apoptotic Cell Clearance	Neutrophil Degranulation Positive Regulation By Host Of Viral Genome Replication Positive Regulation Of Protein Targeting To Membrane Regulation Of Acid-sensing Ion Channel Activity
Pathways		Initial triggering of complement Activation of C3 and C5 Regulation of Complement cascade	Stimuli-sensing channels Neutrophil degranulation
Drugs
Diseases		Classic complement pathway component defects, including the following eight diseases: C1q alpha-chain deficiency; C1q beta-chain deficiency; C1q gamma-chain deficiency; C1r deficiency; C1s deficiency; C2 deficiency; C3 deficiency; C4 deficiency Systemic lupus erythematosus	Hereditary stomatocytosis (HSt); Dehydrated hereditary stomatocytosis (DHS); Overhydrated hereditary stomatocytosis (OHS); Familial pseudohyperkalemia (FP)
GWAS		Advanced age-related macular degeneration ( 26691988) Age-related macular degeneration ( 20385819 20385826 23455636 21665990) Age-related macular degeneration (choroidal neovascularisation) ( 22705344) Age-related macular degeneration (geographic atrophy) ( 22705344) Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 29875488 28240269) Circulating myeloperoxidase levels (serum) ( 23620142) Coffee consumption ( 31046077) Coronary artery disease ( 29212778 30104761) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Disease progression in age-related macular degeneration ( 29346644) Early age-related macular degeneration ( 32843070) Endometriosis ( 28881265) Estimated glomerular filtration rate ( 31451708) Estimated glomerular filtration rate in diabetes ( 31451708) Hepatocellular carcinoma ( 21105107) Inflammatory bowel disease ( 28067908) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Mosquito bite size ( 28199695) Platelet aggregation ( 29185836) Prostate cancer ( 23535732) Sulfasalazine-induced agranulocytosis ( 28762467) Systemic lupus erythematosus ( 24871463) Ulcerative colitis ( 28067908) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		14 interacting genes: C3 C4B C5 CREB3 EBP ERGIC3 FAM209A MASP1 MUC1 PSMA4 SEC11C SLC10A1 SLC35C2 STOM	81 interacting genes: AIG1 APOA2 ASIC1 ASIC2 ASIC3 ATP1B3 ATP6V0B ATP6V0C BCL2L2 BNIP1 C2 C3orf52 CFHR5 CHST1 CLDN19 CLRN2 CMTM5 CNIH3 CTXN3 CYB5B CYB5R3 DAGLA DVL3 EMP1 ERG28 FAXDC2 FUNDC2 GIMAP1 GIMAP5 GPR25 GPR37L1 GRM2 HMOX2 KCNK1 KTN1 LANCL1 LNPEP MGLL MMP14 NKG7 ORMDL1 PEDS1-UBE2V1 PEMT PGA4 PMP22 PTCH1 RPL13A RPRM RTP2 RUVBL1 RUVBL2 SCD SELENOK SERP2 SFT2D1 SFT2D2 SFXN1 SFXN5 SLC2A1 SLC35B4 SMCO4 STX6 TECR THSD7B TMEM109 TMEM120B TMEM140 TMEM14B TMEM203 TMEM208 TMEM254 TMEM60 TMEM86B TMEM98 TMPO TNF TNFRSF10C TSPO2 VAMP4 WFDC2 YIPF6
Entrez ID		717	2040
HPRD ID		08939	00585
Ensembl ID		ENSG00000166278	ENSG00000148175
Uniprot IDs		A0A0G2JL69 B4DQI1 B4DV48 P06681 Q53HP3 Q5JP69 Q8N6L6	A0A024R882 F8VSL7 P27105
PDB IDs		2I6Q 2I6S 2ODP 2ODQ 3ERB
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?