C2 and C4B

Data Source:
BioGRID (pull down)

		C2	C4B
Description		complement C2	complement C4B (Chido blood group)
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Exosome	Extracellular Region Extracellular Space Plasma Membrane Axon Dendrite Other Organism Cell Synapse Extracellular Exosome Blood Microparticle
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Metal Ion Binding	Complement Binding Endopeptidase Inhibitor Activity Carbohydrate Binding
	Biological Process	Proteolysis Complement Activation Complement Activation, Classical Pathway Response To Nutrient Regulation Of Complement Activation Innate Immune Response Positive Regulation Of Apoptotic Cell Clearance	Inflammatory Response Complement Activation Complement Activation, Classical Pathway Opsonization Negative Regulation Of Endopeptidase Activity Regulation Of Complement Activation Detection Of Molecule Of Bacterial Origin Innate Immune Response Positive Regulation Of Apoptotic Cell Clearance
Pathways		Initial triggering of complement Activation of C3 and C5 Regulation of Complement cascade	Initial triggering of complement Activation of C3 and C5 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation Regulation of Complement cascade Initial triggering of complement Activation of C3 and C5 Regulation of Complement cascade
Drugs			Human immunoglobulin G Human immunoglobulin G Zinc Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases		Classic complement pathway component defects, including the following eight diseases: C1q alpha-chain deficiency; C1q beta-chain deficiency; C1q gamma-chain deficiency; C1r deficiency; C1s deficiency; C2 deficiency; C3 deficiency; C4 deficiency Systemic lupus erythematosus
GWAS		Advanced age-related macular degeneration ( 26691988) Age-related macular degeneration ( 20385819 20385826 23455636 21665990) Age-related macular degeneration (choroidal neovascularisation) ( 22705344) Age-related macular degeneration (geographic atrophy) ( 22705344) Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 29875488 28240269) Circulating myeloperoxidase levels (serum) ( 23620142) Coffee consumption ( 31046077) Coronary artery disease ( 29212778 30104761) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Disease progression in age-related macular degeneration ( 29346644) Early age-related macular degeneration ( 32843070) Endometriosis ( 28881265) Estimated glomerular filtration rate ( 31451708) Estimated glomerular filtration rate in diabetes ( 31451708) Hepatocellular carcinoma ( 21105107) Inflammatory bowel disease ( 28067908) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Mosquito bite size ( 28199695) Platelet aggregation ( 29185836) Prostate cancer ( 23535732) Sulfasalazine-induced agranulocytosis ( 28762467) Systemic lupus erythematosus ( 24871463) Ulcerative colitis ( 28067908) Youthful appearance (self-reported) ( 32339537)	Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 29875488 28240269) Feeling worry ( 29500382) Inflammatory bowel disease ( 28067908) Neuromyelitis optica ( 29769526) Neuromyelitis optica (AQP4-IgG-positive) ( 29769526) Prostate cancer ( 23535732) Reticulocyte count ( 32888494) Ulcerative colitis ( 28067908)
Interacting Genes		14 interacting genes: C3 C4B C5 CREB3 EBP ERGIC3 FAM209A MASP1 MUC1 PSMA4 SEC11C SLC10A1 SLC35C2 STOM	1 interacting genes: C2
Entrez ID		717	721
HPRD ID		08939
Ensembl ID		ENSG00000166278	ENSG00000224389
Uniprot IDs		A0A0G2JL69 B4DQI1 B4DV48 P06681 Q53HP3 Q5JP69 Q8N6L6	P0C0L4 P0C0L5
PDB IDs		2I6Q 2I6S 2ODP 2ODQ 3ERB	1HZF 4FXG 4FXK 4XAM 5JPM 5JPN 5JTW 6YSQ
Enriched GO Terms of Interacting Partners?
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