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TJP1 and CLDN1
Data Source:
HPRD
(in vitro)
TJP1
CLDN1
Description
tight junction protein 1
claudin 1
Image
No pdb structure
GO Annotations
Cellular Component
Podosome
Cytoplasm
Cytosol
Plasma Membrane
Adherens Junction
Gap Junction
Bicellular Tight Junction
Basolateral Plasma Membrane
Cell Junction
Protein-containing Complex
Cell Projection
Apical Junction Complex
Apical Part Of Cell
Tight Junction
Cytoplasm
Plasma Membrane
Integral Component Of Plasma Membrane
Bicellular Tight Junction
Integral Component Of Membrane
Basolateral Plasma Membrane
Apical Plasma Membrane
Lateral Plasma Membrane
Protein-containing Complex
Tight Junction
Molecular Function
Protein Binding
Calmodulin Binding
Cadherin Binding
Cell Adhesion Molecule Binding
Virus Receptor Activity
Structural Molecule Activity
Protein Binding
Identical Protein Binding
Biological Process
Cell-cell Junction Assembly
Positive Regulation Of Cell Population Proliferation
Positive Regulation Of Cell Migration
Actomyosin Structure Organization
Adherens Junction Maintenance
Hippo Signaling
Maintenance Of Blood-brain Barrier
Negative Regulation Of Apoptotic Process
Cell-cell Junction Organization
Regulation Of Cytoskeleton Organization
Negative Regulation Of Stress Fiber Assembly
Protein Localization To Adherens Junction
Establishment Of Endothelial Intestinal Barrier
Cell-cell Adhesion
Protein Localization To Cell-cell Junction
Regulation Of Cell Junction Assembly
Protein Localization To Bicellular Tight Junction
Positive Regulation Of Sprouting Angiogenesis
Positive Regulation Of Blood-brain Barrier Permeability
Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin
Negative Regulation Of Actin Cytoskeleton Reorganization
Regulation Of Bicellular Tight Junction Assembly
Cell Adhesion
Aging
Establishment Of Blood-nerve Barrier
Response To Toxic Substance
Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules
Positive Regulation Of Cell Migration
Response To Lipopolysaccharide
Cell Junction Maintenance
Maintenance Of Blood-brain Barrier
Hyperosmotic Salinity Response
Cell-cell Junction Organization
Response To Ethanol
Viral Entry Into Host Cell
Protein Complex Oligomerization
Positive Regulation Of Epithelial Cell Proliferation Involved In Wound Healing
Establishment Of Skin Barrier
Xenobiotic Transport Across Blood-nerve Barrier
Response To Interleukin-18
Bicellular Tight Junction Assembly
Cellular Response To Lead Ion
Cellular Response To Interferon-gamma
Cellular Response To Tumor Necrosis Factor
Response To Dexamethasone
Cellular Response To Transforming Growth Factor Beta Stimulus
Positive Regulation Of Wound Healing
Establishment Of Endothelial Intestinal Barrier
Liver Regeneration
Positive Regulation Of Bicellular Tight Junction Assembly
Cellular Response To Butyrate
Pathways
Regulation of gap junction activity
Regulation of gap junction activity
Signaling by Hippo
Apoptotic cleavage of cell adhesion proteins
RUNX1 regulates expression of components of tight junctions
Tight junction interactions
Drugs
Diseases
Neonatal ichthyosis-sclerosing cholangitis (NISCH) syndrome; Ichthyosis, leukocyte vacuoles, alopecia, and sclerosing cholangitis (ILVASC)
GWAS
Central corneal thickness (
32528159
31798171
29760442
30894546
)
Corneal structure (
23291589
)
Response to antipsychotic treatment (
23241943
)
Optic disc size (
31809533
)
Response to antipsychotic treatment in schizophrenia (working memory) (
21107309
)
Interacting Genes
40 interacting genes:
ACTA1
ACTN4
AFDN
ARVCF
CGN
CLDN1
CLDN16
CLDN2
CLDN3
CLDN4
CLDN5
CLDN6
CLDN7
CLDN8
CNKSR2
CTNNA1
CTTN
EGFR
F11R
GJA1
GJA3
GJA8
GJB3
GJC1
GJD3
GRIN1
GRIN2D
HSP90AA1
JAM2
JAM3
KHDRBS1
KIRREL1
OCLN
PEA15
PTPN14
TJP2
TJP3
TRPC4
UBN1
YBX3
18 interacting genes:
BRD4
CD69
CD79A
CLDN3
DRG1
FNDC9
LNX1
MMP14
MMP2
MPDZ
MS4A3
PATJ
TJP1
TJP2
TJP3
TMEM179B
TMEM9
WNK4
Entrez ID
7082
9076
HPRD ID
03002
04760
Ensembl ID
ENSG00000104067
ENSG00000163347
Uniprot IDs
A9CQZ8
B4DZK4
G3V1L9
G5E9E7
Q07157
Q6MZU1
A5JSJ9
O95832
PDB IDs
2H2B
2H2C
2H3M
2JWE
2KXR
2KXS
2RCZ
3CYY
3LH5
3SHU
3SHW
3TSV
3TSW
3TSZ
4OEO
4OEP
4Q2Q
4YYX
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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