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NKX2-1 and NCOA3
Data Source:
BioGRID
(enzymatic study)
NKX2-1
NCOA3
Description
NK2 homeobox 1
nuclear receptor coactivator 3
Image
No pdb structure
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Protein-containing Complex
Extracellular Exosome
Molecular Function
Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Intronic Transcription Regulatory Region Sequence-specific DNA Binding
DNA Binding
DNA-binding Transcription Factor Activity
Protein Binding
Transcription Factor Binding
Enzyme Binding
RNA Polymerase II Complex Binding
Transcription Coactivator Activity
Histone Acetyltransferase Activity
Protein Binding
Nuclear Receptor Binding
Nuclear Receptor Coactivator Activity
Nuclear Hormone Receptor Binding
Thyroid Hormone Receptor Binding
Protein Dimerization Activity
Protein N-terminus Binding
Disordered Domain Specific Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Neuron Migration
Regulation Of Transcription By RNA Polymerase II
Phospholipid Metabolic Process
Axon Guidance
Brain Development
Endoderm Development
Locomotory Behavior
Response To Hormone
Positive Regulation Of Gene Expression
Negative Regulation Of Epithelial To Mesenchymal Transition
Globus Pallidus Development
Hippocampus Development
Cerebral Cortex Cell Migration
Forebrain Dorsal/ventral Pattern Formation
Forebrain Neuron Fate Commitment
Cerebral Cortex GABAergic Interneuron Differentiation
Pituitary Gland Development
Cell Differentiation
Lung Development
Negative Regulation Of Cell Migration
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Thyroid Gland Development
Forebrain Development
Developmental Induction
Leydig Cell Differentiation
Positive Regulation Of Circadian Rhythm
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Rhythmic Process
Anatomical Structure Formation Involved In Morphogenesis
Oligodendrocyte Differentiation
Lung Saccule Development
Epithelial Tube Branching Involved In Lung Morphogenesis
Club Cell Differentiation
Type II Pneumocyte Differentiation
Histone Acetylation
Cellular Response To Hormone Stimulus
Receptor Transactivation
Cell Dedifferentiation
Positive Regulation Of Keratinocyte Differentiation
Positive Regulation Of Transcription By RNA Polymerase II
Cellular Response To Estradiol Stimulus
Positive Regulation Of Stem Cell Population Maintenance
Regulation Of Stem Cell Division
Pathways
PPARA activates gene expression
Transcriptional regulation of white adipocyte differentiation
Transcriptional regulation of white adipocyte differentiation
Activation of anterior HOX genes in hindbrain development during early embryogenesis
MAPK6/MAPK4 signaling
Estrogen-dependent gene expression
Drugs
Diseases
Choreoathetosis, hypothyroidism, and neonatal respiratory distress
GWAS
Differentiated thyroid cancer (
28703219
)
Height (
18391950
)
Menarche (age at onset) (
23667675
29773799
)
Papillary thyroid cancer (
28703219
)
Thyroid cancer (
19198613
)
Apolipoprotein A1 levels (
32203549
)
HDL cholesterol levels (
32203549
)
Osteoarthritis (hip) (
23989986
)
Response to treatment for acute lymphoblastic leukemia (
19176441
)
Interacting Genes
15 interacting genes:
CALR
CAVIN1
CREBBP
FOXA1
GATA6
HIPK2
MAPK1
NCOA1
NCOA2
NCOA3
PAX8
RARA
RELA
TDG
WWTR1
82 interacting genes:
ABL1
ANKRD11
AR
ARNT2
ATAD2
BABAM2
BMP6
BMP7
BRCA1
CCND1
CDKN3
CHUK
CREBBP
CSNK1E
DCTN6
DDX17
DDX5
E2F1
EP300
ESR1
ESR2
ESRRA
ESRRB
ETV1
FOS
GSK3B
GTF2B
H3-4
H4-16
HNF1A
IKBKB
IKBKG
IQCK
JUN
KAT2B
MAPK1
MAPK14
MAPK8
MMS19
MN1
MRTFA
MRTFB
NCOR1
NCOR2
NKX2-1
NPAS2
NR0B2
NR1H2
NR1H3
NR1I2
NR1I3
NR2F1
NR3C1
NR4A1
NR5A2
PGR
PIN1
PPARA
PPARD
PPARG
PRKCZ
PRMT1
PSMB9
PSME3
RARA
RARB
RARG
RELA
RXRA
RXRB
SLC22A2
SMARCE1
SPOP
SUFU
SUMO1
TBP
THRB
TP53
TP53BP1
VDR
YWHAH
YWHAQ
Entrez ID
7080
8202
HPRD ID
02798
03570
Ensembl ID
ENSG00000136352
ENSG00000124151
Uniprot IDs
P43699
Q59EE8
Q9Y6Q9
PDB IDs
1KBH
3L3X
3L3Z
6ES7
6SQC
Enriched GO Terms of Interacting Partners
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