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NKX2-1 and CALR
Data Source:
HPRD
(in vivo)
NKX2-1
CALR
Description
NK2 homeobox 1
calreticulin
Image
No pdb structure
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Acrosomal Vesicle
Extracellular Region
Extracellular Space
Nucleus
Nuclear Envelope
Cytoplasm
Endoplasmic Reticulum
Endoplasmic Reticulum Lumen
Endoplasmic Reticulum Membrane
Smooth Endoplasmic Reticulum
Golgi Apparatus
Cytosol
Polysome
Focal Adhesion
External Side Of Plasma Membrane
Cell Surface
Membrane
Phagocytic Vesicle Membrane
Sarcoplasmic Reticulum Lumen
Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane
MHC Class I Peptide Loading Complex
Endoplasmic Reticulum Quality Control Compartment
Perinuclear Region Of Cytoplasm
Collagen-containing Extracellular Matrix
Extracellular Exosome
Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane
Endocytic Vesicle Lumen
Molecular Function
Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Intronic Transcription Regulatory Region Sequence-specific DNA Binding
DNA Binding
DNA-binding Transcription Factor Activity
Protein Binding
Transcription Factor Binding
Enzyme Binding
Complement Component C1q Complex Binding
DNA Binding
RNA Binding
MRNA Binding
Integrin Binding
Iron Ion Binding
Calcium Ion Binding
Protein Binding
Zinc Ion Binding
Carbohydrate Binding
Ubiquitin Protein Ligase Binding
Peptide Binding
Hormone Binding
Protein Folding Chaperone
Androgen Receptor Binding
Unfolded Protein Binding
Chaperone Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Neuron Migration
Regulation Of Transcription By RNA Polymerase II
Phospholipid Metabolic Process
Axon Guidance
Brain Development
Endoderm Development
Locomotory Behavior
Response To Hormone
Positive Regulation Of Gene Expression
Negative Regulation Of Epithelial To Mesenchymal Transition
Globus Pallidus Development
Hippocampus Development
Cerebral Cortex Cell Migration
Forebrain Dorsal/ventral Pattern Formation
Forebrain Neuron Fate Commitment
Cerebral Cortex GABAergic Interneuron Differentiation
Pituitary Gland Development
Cell Differentiation
Lung Development
Negative Regulation Of Cell Migration
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Thyroid Gland Development
Forebrain Development
Developmental Induction
Leydig Cell Differentiation
Positive Regulation Of Circadian Rhythm
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Rhythmic Process
Anatomical Structure Formation Involved In Morphogenesis
Oligodendrocyte Differentiation
Lung Saccule Development
Epithelial Tube Branching Involved In Lung Morphogenesis
Club Cell Differentiation
Type II Pneumocyte Differentiation
Negative Regulation Of Transcription By RNA Polymerase II
Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent
Peptide Antigen Assembly With MHC Class I Protein Complex
Regulation Of Transcription, DNA-templated
Protein Folding
Protein Export From Nucleus
Cellular Calcium Ion Homeostasis
Receptor-mediated Endocytosis
Spermatogenesis
Positive Regulation Of Cell Population Proliferation
Positive Regulation Of Endothelial Cell Migration
Positive Regulation Of Gene Expression
Negative Regulation Of Translation
Protein Maturation By Protein Folding
Cortical Actin Cytoskeleton Organization
Endoplasmic Reticulum Unfolded Protein Response
Response To Estradiol
Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway
Response To Testosterone
Protein Localization To Nucleus
Protein Folding In Endoplasmic Reticulum
ATF6-mediated Unfolded Protein Response
Regulation Of Meiotic Nuclear Division
Response To Drug
Glucocorticoid Receptor Signaling Pathway
Regulation Of Apoptotic Process
Negative Regulation Of Neuron Differentiation
Positive Regulation Of Cell Cycle
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Retinoic Acid Receptor Signaling Pathway
Positive Regulation Of Phagocytosis
Protein Stabilization
Sequestering Of Calcium Ion
Cardiac Muscle Cell Differentiation
Negative Regulation Of Cell Cycle Arrest
Cellular Response To Lithium Ion
Cellular Senescence
Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Negative Regulation Of Trophoblast Cell Migration
Positive Regulation Of NIK/NF-kappaB Signaling
Vesicle Fusion With Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) Membrane
Positive Regulation Of Dendritic Cell Chemotaxis
Pathways
ER-Phagosome pathway
Assembly of Viral Components at the Budding Site
Scavenging by Class A Receptors
Scavenging by Class A Receptors
Scavenging by Class F Receptors
Scavenging by Class F Receptors
ATF6 (ATF6-alpha) activates chaperone genes
Calnexin/calreticulin cycle
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Drugs
Antihemophilic factor, human recombinant
Tenecteplase
Melatonin
Lanoteplase
Copper
Calcium citrate
Calcium Phosphate
Lonoctocog alfa
Moroctocog alfa
Calcium phosphate dihydrate
Diseases
Choreoathetosis, hypothyroidism, and neonatal respiratory distress
GWAS
Differentiated thyroid cancer (
28703219
)
Height (
18391950
)
Menarche (age at onset) (
23667675
29773799
)
Papillary thyroid cancer (
28703219
)
Thyroid cancer (
19198613
)
Clozapine-induced agranulocytosis (
25187353
)
Estimated glomerular filtration rate (
31152163
)
Platelet count (
32888494
)
Red blood cell traits (
23222517
)
Interacting Genes
15 interacting genes:
CALR
CAVIN1
CREBBP
FOXA1
GATA6
HIPK2
MAPK1
NCOA1
NCOA2
NCOA3
PAX8
RARA
RELA
TDG
WWTR1
50 interacting genes:
APOB
APP
AR
B2M
CD1D
F5
F8
FBN1
FGB
GSC2
HLA-A
HLA-C
HLA-E
ITGA2B
ITGA3
ITGAV
LPL
LRIF1
LRP1
MAPK6
MBL2
MTNR1A
NKX2-1
NR3C1
PDIA2
PDIA3
PLAT
PLP1
PRF1
PTPN11
RNY1
RNY3
RNY4
SCARF1
SGTB
SIRPA
SLC2A1
SLC6A4
SMARCB1
SQSTM1
SUMO4
TAF1B
TAPBP
TF
THBS1
TRIM21
TSHR
UBE3A
UPF2
VWF
Entrez ID
7080
811
HPRD ID
02798
00169
Ensembl ID
ENSG00000136352
ENSG00000179218
Uniprot IDs
P43699
P27797
V9HW88
PDB IDs
2CLR
3DOW
3POS
3POW
5LK5
5V90
6ENY
Enriched GO Terms of Interacting Partners
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