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NCOA3 and E2F1
Data Source:
HPRD
(in vitro, in vivo)
NCOA3
E2F1
Description
nuclear receptor coactivator 3
E2F transcription factor 1
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Protein-containing Complex
Extracellular Exosome
Chromatin
Nucleus
Nucleoplasm
Mitochondrion
Centrosome
Protein-containing Complex
Rb-E2F Complex
RNA Polymerase II Transcription Regulator Complex
Molecular Function
RNA Polymerase II Complex Binding
Transcription Coactivator Activity
Histone Acetyltransferase Activity
Protein Binding
Nuclear Receptor Binding
Nuclear Receptor Coactivator Activity
Nuclear Hormone Receptor Binding
Thyroid Hormone Receptor Binding
Protein Dimerization Activity
Protein N-terminus Binding
Disordered Domain Specific Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Activator Activity
DNA Binding
DNA-binding Transcription Factor Activity
Protein Binding
Transcription Factor Binding
Protein Kinase Binding
Sequence-specific DNA Binding
Protein Dimerization Activity
Sequence-specific Double-stranded DNA Binding
Biological Process
Histone Acetylation
Cellular Response To Hormone Stimulus
Receptor Transactivation
Cell Dedifferentiation
Positive Regulation Of Keratinocyte Differentiation
Positive Regulation Of Transcription By RNA Polymerase II
Cellular Response To Estradiol Stimulus
Positive Regulation Of Stem Cell Population Maintenance
Regulation Of Stem Cell Division
DNA Damage Checkpoint
G1/S Transition Of Mitotic Cell Cycle
Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle
Negative Regulation Of Transcription By RNA Polymerase II
Transcription, DNA-templated
Regulation Of Transcription, DNA-templated
Regulation Of Transcription By RNA Polymerase II
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Spermatogenesis
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Positive Regulation Of Gene Expression
Viral Process
Forebrain Development
Positive Regulation Of Apoptotic Process
Anoikis
Negative Regulation Of DNA Binding
Negative Regulation Of Fat Cell Differentiation
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Fibroblast Proliferation
MRNA Stabilization
Positive Regulation Of Glial Cell Proliferation
Negative Regulation Of G0 To G1 Transition
Negative Regulation Of Fat Cell Proliferation
Cellular Response To Fatty Acid
Cellular Response To Hypoxia
Cellular Response To Xenobiotic Stimulus
Negative Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle
Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Lens Fiber Cell Apoptotic Process
Cellular Response To Nerve Growth Factor Stimulus
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways
PPARA activates gene expression
Transcriptional regulation of white adipocyte differentiation
Transcriptional regulation of white adipocyte differentiation
Activation of anterior HOX genes in hindbrain development during early embryogenesis
MAPK6/MAPK4 signaling
Estrogen-dependent gene expression
Activation of NOXA and translocation to mitochondria
Inhibition of replication initiation of damaged DNA by RB1/E2F1
Transcription of E2F targets under negative control by DREAM complex
Transcription of E2F targets under negative control by DREAM complex
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
Activation of PUMA and translocation to mitochondria
Pre-NOTCH Transcription and Translation
Pre-NOTCH Transcription and Translation
Oxidative Stress Induced Senescence
Oncogene Induced Senescence
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
CDC6 association with the ORC:origin complex
G2 Phase
Cyclin E associated events during G1/S transition
G1/S-Specific Transcription
G1/S-Specific Transcription
Cyclin D associated events in G1
Cyclin A:Cdk2-associated events at S phase entry
Transcriptional Regulation by E2F6
Transcriptional regulation of granulopoiesis
Transcriptional regulation of granulopoiesis
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
Drugs
Diseases
GWAS
Apolipoprotein A1 levels (
32203549
)
HDL cholesterol levels (
32203549
)
Osteoarthritis (hip) (
23989986
)
Response to treatment for acute lymphoblastic leukemia (
19176441
)
Heel bone mineral density (
30598549
)
Height (
31562340
)
Interacting Genes
82 interacting genes:
ABL1
ANKRD11
AR
ARNT2
ATAD2
BABAM2
BMP6
BMP7
BRCA1
CCND1
CDKN3
CHUK
CREBBP
CSNK1E
DCTN6
DDX17
DDX5
E2F1
EP300
ESR1
ESR2
ESRRA
ESRRB
ETV1
FOS
GSK3B
GTF2B
H3-4
H4-16
HNF1A
IKBKB
IKBKG
IQCK
JUN
KAT2B
MAPK1
MAPK14
MAPK8
MMS19
MN1
MRTFA
MRTFB
NCOR1
NCOR2
NKX2-1
NPAS2
NR0B2
NR1H2
NR1H3
NR1I2
NR1I3
NR2F1
NR3C1
NR4A1
NR5A2
PGR
PIN1
PPARA
PPARD
PPARG
PRKCZ
PRMT1
PSMB9
PSME3
RARA
RARB
RARG
RELA
RXRA
RXRB
SLC22A2
SMARCE1
SPOP
SUFU
SUMO1
TBP
THRB
TP53
TP53BP1
VDR
YWHAH
YWHAQ
82 interacting genes:
ARID3A
ATAD2
ATM
ATR
BIN1
BIRC2
BRCA1
BRD2
BRMS1
BTRC
CCNA1
CCNA2
CDK1
CDK2
CDK3
CDK7
CDKN2A
CEBPE
CHEK2
CREBBP
CTDP1
CUL1
CUL2
DDB2
DIABLO
E2F6
EP300
ERCC3
FHL2
GSK3B
GTF2H1
HCFC1
IGF1
KAT5
KDM1A
MDM2
MDM4
MGA
MNAT1
MTA1
MYBL2
NCOA3
NCOA6
NCOR2
NDN
NFKB1
NPDC1
NRIP1
NSMCE3
PARP1
PHB
PKIB
PRDM2
PURA
RARA
RB1
RBL1
RNF126
RNF144A
SERTAD2
SETD7
SIRT1
SKP2
SP1
SP2
SP3
SP4
SPIB
STAT1
STOML1
TBP
TEAD3
TFDP1
TFDP2
TOPBP1
TP53
TP53BP1
TRRAP
UBE3A
UCHL5
VHL
YWHAQ
Entrez ID
8202
1869
HPRD ID
03570
01806
Ensembl ID
ENSG00000124151
ENSG00000101412
Uniprot IDs
Q59EE8
Q9Y6Q9
Q01094
Q9BSD8
PDB IDs
1KBH
3L3X
3L3Z
6ES7
6SQC
1H24
1O9K
2AZE
5M9N
5M9O
6G0P
6ULS
Enriched GO Terms of Interacting Partners
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