TIE1 and MTMR14

Data Source:
BioGRID (two hybrid)

		TIE1	MTMR14
Description		tyrosine kinase with immunoglobulin like and EGF like domains 1	myotubularin related protein 14
Image			No pdb structure
GO Annotations	Cellular Component	Integral Component Of Plasma Membrane Receptor Complex	Ruffle Cytosol Perinuclear Region Of Cytoplasm
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding	Phosphatidylinositol-3-phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding
	Biological Process	Angiogenesis Vasculogenesis In Utero Embryonic Development Regulation Of Endothelial Cell Proliferation Aortic Valve Morphogenesis Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Mesoderm Development Negative Regulation Of Angiogenesis Peptidyl-tyrosine Phosphorylation Negative Regulation Of Cell Migration Response To Retinoic Acid Positive Regulation Of Kinase Activity Plasma Membrane Fusion Positive Regulation Of Angiogenesis Tissue Remodeling Lymphatic Endothelial Cell Differentiation Branching Involved In Lymph Vessel Morphogenesis Regulation Of Extracellular Matrix Assembly	Phosphatidylinositol Biosynthetic Process Macroautophagy Peptidyl-tyrosine Dephosphorylation
Pathways			Macroautophagy Synthesis of PIPs at the plasma membrane
Drugs		Fostamatinib
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Hemoglobin levels ( 32327693) Platelet count ( 32888494) Red blood cell count ( 32888494) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Daytime sleep phenotypes ( 27126917)
Interacting Genes		13 interacting genes: ANGPT1 ANGPT4 KRT40 KRTAP10-8 MDFI MTMR14 PIK3R1 PSG5 PTPN11 RBPMS TEK TRIP6 ZRANB1	8 interacting genes: APP ENO3 EPHA1 EPHA7 EPHB2 LTK TIE1 TP53BP2
Entrez ID		7075	64419
HPRD ID		02572	08654
Ensembl ID		ENSG00000066056	ENSG00000163719
Uniprot IDs		B4DTW8 P35590	Q8NCE2 Q8WYY9
PDB IDs		5N06
Enriched GO Terms of Interacting Partners?
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