TIE1

Description		tyrosine kinase with immunoglobulin like and EGF like domains 1
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GO Annotations	Cellular Component	Integral Component Of Plasma Membrane Receptor Complex
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding
	Biological Process	Angiogenesis Vasculogenesis In Utero Embryonic Development Regulation Of Endothelial Cell Proliferation Aortic Valve Morphogenesis Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Mesoderm Development Negative Regulation Of Angiogenesis Peptidyl-tyrosine Phosphorylation Negative Regulation Of Cell Migration Response To Retinoic Acid Positive Regulation Of Kinase Activity Plasma Membrane Fusion Positive Regulation Of Angiogenesis Tissue Remodeling Lymphatic Endothelial Cell Differentiation Branching Involved In Lymph Vessel Morphogenesis Regulation Of Extracellular Matrix Assembly
Pathways
Drugs		Fostamatinib
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Hemoglobin levels ( 32327693) Platelet count ( 32888494) Red blood cell count ( 32888494) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		13 interacting genes: ANGPT1 ANGPT4 KRT40 KRTAP10-8 MDFI MTMR14 PIK3R1 PSG5 PTPN11 RBPMS TEK TRIP6 ZRANB1
Entrez ID		7075
HPRD ID		02572
Ensembl ID		ENSG00000066056
Uniprot IDs		B4DTW8 P35590
PDB IDs		5N06
Enriched GO Terms of Interacting Partners?
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