MTMR14 and EPHA7

Data Source:
BioGRID (two hybrid)

		MTMR14	EPHA7
Description		myotubularin related protein 14	EPH receptor A7
Image		No pdb structure
GO Annotations	Cellular Component	Ruffle Cytosol Perinuclear Region Of Cytoplasm	Plasma Membrane Integral Component Of Plasma Membrane Dendrite Neuromuscular Junction Neuron Projection Neuronal Cell Body Receptor Complex Schaffer Collateral - CA1 Synapse Hippocampal Mossy Fiber To CA3 Synapse Glutamatergic Synapse Integral Component Of Postsynaptic Density Membrane
	Molecular Function	Phosphatidylinositol-3-phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity GPI-linked Ephrin Receptor Activity Transmembrane-ephrin Receptor Activity Protein Binding ATP Binding Axon Guidance Receptor Activity Chemorepellent Activity Ephrin Receptor Binding
	Biological Process	Phosphatidylinositol Biosynthetic Process Macroautophagy Peptidyl-tyrosine Dephosphorylation	Positive Regulation Of Protein Phosphorylation Apoptotic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Axon Guidance Brain Development Phosphorylation Peptidyl-tyrosine Phosphorylation Regulation Of Cell-cell Adhesion Retinal Ganglion Cell Axon Guidance Regulation Of Protein Autophosphorylation Positive Regulation Of Kinase Activity Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Ephrin Receptor Signaling Pathway Negative Regulation Of Collateral Sprouting Branching Morphogenesis Of A Nerve Regulation Of Peptidyl-tyrosine Phosphorylation Negative Chemotaxis Negative Regulation Of Synapse Assembly Regulation Of ERK1 And ERK2 Cascade Nephric Duct Morphogenesis Regulation Of Postsynapse Organization
Pathways		Macroautophagy Synthesis of PIPs at the plasma membrane	EPH-Ephrin signaling EPH-Ephrin signaling EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells EPH-ephrin mediated repulsion of cells
Drugs			5-[(2-methyl-5-{[3-(trifluoromethyl)phenyl]carbamoyl}phenyl)amino]pyridine-3-carboxamide Fostamatinib
Diseases
GWAS		Daytime sleep phenotypes ( 27126917)	Adult body size ( 32376654) Adventurousness ( 30643258) Anthropometric traits (multi-trait analysis) ( 30166351) Chin dimples ( 27182965) Dialysis-related mortality ( 21546767) Diisocyanate-induced asthma ( 25918132) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Gut microbiota relative abundance (Eubacterium belonging to family Erysipelotrichaceae) ( 33208821) Initial pursuit acceleration ( 29064472) Laryngeal squamous cell carcinoma ( 25194280) Response to cytadine analogues (cytosine arabinoside) ( 24483146) Response to hepatitis C treatment ( 22095909) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258) Waist circumference adjusted for body mass index ( 28552196)
Interacting Genes		8 interacting genes: APP ENO3 EPHA1 EPHA7 EPHB2 LTK TIE1 TP53BP2	12 interacting genes: AFDN DUSP18 DUSP26 EFNA1 EFNA3 EFNA4 EFNA5 GNB1 MAP1LC3A MTMR14 STYX ZNF267
Entrez ID		64419	2045
HPRD ID		08654	03721
Ensembl ID		ENSG00000163719	ENSG00000135333
Uniprot IDs		Q8NCE2 Q8WYY9	Q15375
PDB IDs			2REI 3DKO 3H8M 3NRU
Enriched GO Terms of Interacting Partners?
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