MTMR14 and EPHA1

Data Source:
BioGRID (two hybrid)

		MTMR14	EPHA1
Description		myotubularin related protein 14	EPH receptor A1
Image		No pdb structure
GO Annotations	Cellular Component	Ruffle Cytosol Perinuclear Region Of Cytoplasm	Plasma Membrane Integral Component Of Plasma Membrane Neuron Projection Receptor Complex
	Molecular Function	Phosphatidylinositol-3-phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding	Fibronectin Binding Protein Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Transmembrane-ephrin Receptor Activity ATP Binding Protein Kinase Binding
	Biological Process	Phosphatidylinositol Biosynthetic Process Macroautophagy Peptidyl-tyrosine Dephosphorylation	Angiogenesis Positive Regulation Of Cell-matrix Adhesion Negative Regulation Of Protein Kinase Activity Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Axon Guidance Positive Regulation Of Cell Population Proliferation Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cell Migration Negative Regulation Of Cell Migration Positive Regulation Of Kinase Activity Substrate Adhesion-dependent Cell Spreading Somatic Stem Cell Population Maintenance Regulation Of GTPase Activity Positive Regulation Of Angiogenesis Protein Autophosphorylation Ephrin Receptor Signaling Pathway Positive Regulation Of Stress Fiber Assembly Activation Of GTPase Activity
Pathways		Macroautophagy Synthesis of PIPs at the plasma membrane	EPH-Ephrin signaling EPH-Ephrin signaling POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells EPH-ephrin mediated repulsion of cells
Drugs			Fostamatinib
Diseases
GWAS		Daytime sleep phenotypes ( 27126917)	Alzheimer's disease ( 31473137) Alzheimer's disease (late onset) ( 21460841 30617256 24162737) Alzheimer's disease in APOE e4- carriers ( 25778476) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Blood protein levels ( 30072576 29875488 28240269) Family history of Alzheimer's disease ( 30617256)
Interacting Genes		8 interacting genes: APP ENO3 EPHA1 EPHA7 EPHB2 LTK TIE1 TP53BP2	12 interacting genes: CTDSP2 DAPK1 DUSP14 EFNA1 ERBB2 GJB1 MAP3K1 MTMR14 PTPN11 SMURF1 SMURF2 TPTE
Entrez ID		64419	2041
HPRD ID		08654	01554
Ensembl ID		ENSG00000163719	ENSG00000146904
Uniprot IDs		Q8NCE2 Q8WYY9	P21709
PDB IDs			2K1K 2K1L 3HIL 3KKA
Enriched GO Terms of Interacting Partners?
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