THY1 and CCR8

Data Source:
BioGRID (two hybrid)

		THY1	CCR8
Description		Thy-1 cell surface antigen	C-C motif chemokine receptor 8
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Cell Surface Apical Plasma Membrane Dendrite Growth Cone Axolemma Anchored Component Of External Side Of Plasma Membrane Dendrite Membrane Neuronal Cell Body Membrane Membrane Raft Extracellular Exosome	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane
	Molecular Function	GTPase Activator Activity Integrin Binding Protein Binding Protein Kinase Binding GPI Anchor Binding	Chemokine Receptor Activity Coreceptor Activity C-C Chemokine Receptor Activity C-C Chemokine Binding
	Biological Process	Angiogenesis Regulation Of Cell-matrix Adhesion Positive Regulation Of Cellular Extravasation Negative Regulation Of Protein Kinase Activity Cytoskeleton Organization Integrin-mediated Signaling Pathway Cell-cell Signaling Negative Regulation Of Cell Migration Positive Regulation Of Heterotypic Cell-cell Adhesion Receptor Clustering Positive Regulation Of GTPase Activity Retinal Cone Cell Development Focal Adhesion Assembly Negative Regulation Of Axonogenesis T Cell Receptor Signaling Pathway Negative Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Activation Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Focal Adhesion Assembly Negative Regulation Of Protein Tyrosine Kinase Activity Negative Regulation Of Neuron Projection Regeneration Cell-cell Adhesion Regulation Of Rho-dependent Protein Serine/threonine Kinase Activity	Chemotaxis Immune Response Cell Adhesion G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium-mediated Signaling Cell Chemotaxis Chemokine-mediated Signaling Pathway
Pathways		Post-translational modification: synthesis of GPI-anchored proteins	Chemokine receptors bind chemokines G alpha (i) signalling events
Drugs
Diseases
GWAS		Refractive error ( 32231278)	Daytime sleep phenotypes ( 27126917) Medication use (thyroid preparations) ( 31015401)
Interacting Genes		10 interacting genes: ATXN1L ATXN7 CCR8 CLK1 FYN HTR6 ITGAM ITGAV ITGB3 LCK	19 interacting genes: ATP2A1 CCL1 CCL16 CCL17 CCL4 EI24 ERGIC3 GABBR1 GABRD NAGPA PAQR6 PLEKHB1 RTN3 SPNS1 SPP1 THY1 TPST1 TPST2 UCKL1
Entrez ID		7070	1237
HPRD ID		01769	03497
Ensembl ID		ENSG00000154096	ENSG00000179934
Uniprot IDs		B0YJA4 P04216	P51685
PDB IDs
Enriched GO Terms of Interacting Partners?
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